MX350234B - Compuestos de enlace especificos de bacterias gram-positivas. - Google Patents

Compuestos de enlace especificos de bacterias gram-positivas.

Info

Publication number
MX350234B
MX350234B MX2014012186A MX2014012186A MX350234B MX 350234 B MX350234 B MX 350234B MX 2014012186 A MX2014012186 A MX 2014012186A MX 2014012186 A MX2014012186 A MX 2014012186A MX 350234 B MX350234 B MX 350234B
Authority
MX
Mexico
Prior art keywords
gram
binding compounds
positive bacteria
specific binding
bacteria specific
Prior art date
Application number
MX2014012186A
Other languages
English (en)
Inventor
Yi Xia
Sanjeev Mariathasan
Tim Beaumont
Mark Jeroen Kwakkenbos
Eric J Brown
John Hiroshi Morisaki
Wouter L W Hazenbos
Kimberly Kajihara
Original Assignee
Aimm Therapeutics Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aimm Therapeutics Bv filed Critical Aimm Therapeutics Bv
Publication of MX350234B publication Critical patent/MX350234B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un anticuerpo o parte funcional del mismo que se enlaza a un epítopo dependiente de repetición de serina-aspartato (SD) de una proteína de repetición de SD (sdr), en done el anticuerpo o parte funcional del mismo se acopla a un agente citotóxico para formar un conjugado de anticuerpo-fármaco.
MX2014012186A 2009-07-15 2010-07-15 Compuestos de enlace especificos de bacterias gram-positivas. MX350234B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22587809P 2009-07-15 2009-07-15
EP09165558 2009-07-15
PCT/NL2010/050456 WO2011008092A2 (en) 2009-07-15 2010-07-15 Gram-positive bacteria specific binding compounds

Publications (1)

Publication Number Publication Date
MX350234B true MX350234B (es) 2017-08-30

Family

ID=41467048

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014012186A MX350234B (es) 2009-07-15 2010-07-15 Compuestos de enlace especificos de bacterias gram-positivas.

Country Status (24)

Country Link
US (9) US20110020323A1 (es)
EP (1) EP2454284B1 (es)
JP (3) JP6192294B2 (es)
KR (1) KR101832201B1 (es)
CN (2) CN105440133A (es)
AR (1) AR077756A1 (es)
AU (2) AU2010271582B2 (es)
BR (1) BR112012000953A8 (es)
CA (1) CA2768204A1 (es)
DK (1) DK2454284T3 (es)
EA (1) EA031447B1 (es)
ES (1) ES2673323T3 (es)
HK (1) HK1222418A1 (es)
HU (1) HUE038277T2 (es)
IL (3) IL217497A (es)
MX (1) MX350234B (es)
NZ (2) NZ616921A (es)
PL (1) PL2454284T3 (es)
SG (2) SG10201704269RA (es)
SI (1) SI2454284T1 (es)
TR (1) TR201809128T4 (es)
TW (2) TWI502068B (es)
WO (1) WO2011008092A2 (es)
ZA (2) ZA201200363B (es)

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Also Published As

Publication number Publication date
CA2768204A1 (en) 2011-01-20
US20160168232A9 (en) 2016-06-16
EP2454284A2 (en) 2012-05-23
HUE038277T2 (hu) 2018-10-29
NZ598063A (en) 2014-07-25
JP6192294B2 (ja) 2017-09-06
US20110020323A1 (en) 2011-01-27
SI2454284T1 (en) 2018-07-31
TR201809128T4 (tr) 2018-07-23
NZ616921A (en) 2015-06-26
HK1222418A1 (zh) 2017-06-30
US20140235828A1 (en) 2014-08-21
JP2016135771A (ja) 2016-07-28
PL2454284T3 (pl) 2018-09-28
DK2454284T3 (en) 2018-07-02
US20130261293A1 (en) 2013-10-03
TW201610153A (zh) 2016-03-16
IL217497A0 (en) 2012-02-29
IL242207A0 (en) 2015-11-30
US20180292391A1 (en) 2018-10-11
WO2011008092A2 (en) 2011-01-20
AU2016250398A1 (en) 2016-11-17
US20150376266A1 (en) 2015-12-31
US20170067880A1 (en) 2017-03-09
ZA201200363B (en) 2014-06-25
US20130253175A1 (en) 2013-09-26
EA031447B1 (ru) 2019-01-31
WO2011008092A3 (en) 2011-05-26
AU2010271582A2 (en) 2013-05-16
KR101832201B1 (ko) 2018-02-28
US9458228B2 (en) 2016-10-04
AR077756A1 (es) 2011-09-21
CN105440133A (zh) 2016-03-30
US20160222096A1 (en) 2016-08-04
US9927428B2 (en) 2018-03-27
US20120157665A1 (en) 2012-06-21
IL238074A (en) 2016-06-30
SG177653A1 (en) 2012-02-28
AU2010271582B2 (en) 2016-07-28
AU2010271582A1 (en) 2012-03-01
EA201390967A1 (ru) 2014-01-30
JP2012533293A (ja) 2012-12-27
WO2011008092A4 (en) 2011-07-07
IL217497A (en) 2015-11-30
US8617556B2 (en) 2013-12-31
BR112012000953A8 (pt) 2017-12-26
JP2018134089A (ja) 2018-08-30
AU2016250398B2 (en) 2018-09-27
CN102666583A (zh) 2012-09-12
US9399673B2 (en) 2016-07-26
US9090677B2 (en) 2015-07-28
TWI502068B (zh) 2015-10-01
SG10201704269RA (en) 2017-06-29
ES2673323T3 (es) 2018-06-21
EP2454284B1 (en) 2018-04-11
ZA201400644B (en) 2015-10-28
CN102666583B (zh) 2015-11-25
KR20120065326A (ko) 2012-06-20
US9266943B2 (en) 2016-02-23
US9688745B2 (en) 2017-06-27
BR112012000953A2 (pt) 2016-11-22
TW201107470A (en) 2011-03-01

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