MX341838B - Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos. - Google Patents

Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos.

Info

Publication number
MX341838B
MX341838B MX2013000908A MX2013000908A MX341838B MX 341838 B MX341838 B MX 341838B MX 2013000908 A MX2013000908 A MX 2013000908A MX 2013000908 A MX2013000908 A MX 2013000908A MX 341838 B MX341838 B MX 341838B
Authority
MX
Mexico
Prior art keywords
sulfatase
acetylgalactosamine
manufacture
highly phosphorylated
phosphorylated human
Prior art date
Application number
MX2013000908A
Other languages
English (en)
Other versions
MX2013000908A (es
Inventor
Araya Kidisti
O Okhamafe Augustus
Koppaka Vish
Claude Vellard Michel
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of MX2013000908A publication Critical patent/MX2013000908A/es
Publication of MX341838B publication Critical patent/MX341838B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06004—N-Acetylgalactosamine-6-sulfatase (3.1.6.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a composiciones de Nacetilgalactosamina-6-sulfatasa humana, altamente fosforilada (GALNS), y composiciones y formulaciones farmacéuticas de la misma, métodos para producir y purificar GALNS, y su uso en el diagnóstico, profilaxis, o tratamiento de enfermedades y condiciones, incluyendo particularmente enfermedades de almacenamiento lisosomal que son causadas por, o están - asociadas con, una deficiencia en la enzima GALNS, por ejemplo, Mucopolisacaridosis IVa (MPS IVa o síndrome de Morquio A). Figura 11.
MX2013000908A 2010-07-22 2011-07-22 Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos. MX341838B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36671410P 2010-07-22 2010-07-22
PCT/US2011/045011 WO2012012718A2 (en) 2010-07-22 2011-07-22 Manufacture of active highly phosphorylated human n-acetylgalactosamine-6-sulfatase and uses thereof

Publications (2)

Publication Number Publication Date
MX2013000908A MX2013000908A (es) 2013-07-05
MX341838B true MX341838B (es) 2016-09-05

Family

ID=44543776

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000908A MX341838B (es) 2010-07-22 2011-07-22 Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos.

Country Status (28)

Country Link
US (3) US8765437B2 (es)
EP (1) EP2595650B1 (es)
JP (2) JP6030553B2 (es)
KR (2) KR101598897B1 (es)
CN (1) CN103037895B (es)
AR (2) AR082319A1 (es)
AU (1) AU2011280937B2 (es)
BR (1) BR112013001558B1 (es)
CA (2) CA3146151A1 (es)
CL (2) CL2013000219A1 (es)
CY (1) CY1118934T1 (es)
DK (1) DK2595650T3 (es)
ES (1) ES2616263T3 (es)
HR (1) HRP20170245T1 (es)
HU (1) HUE033163T2 (es)
IL (2) IL224125B (es)
LT (1) LT2595650T (es)
MX (1) MX341838B (es)
PE (3) PE20171798A1 (es)
PL (1) PL2595650T3 (es)
PT (1) PT2595650T (es)
RS (1) RS55669B1 (es)
RU (1) RU2607376C2 (es)
SG (1) SG187580A1 (es)
SI (1) SI2595650T1 (es)
SM (1) SMT201700106B (es)
WO (1) WO2012012718A2 (es)
ZA (1) ZA201300286B (es)

Families Citing this family (17)

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HUE032074T2 (en) * 2008-01-18 2017-08-28 Biomarin Pharm Inc Preparation and use of active, highly phosphorylated, human lisosomal sulfatase enzymes
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2013119715A1 (en) * 2012-02-07 2013-08-15 Saint Louis University Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US11529397B2 (en) 2018-01-22 2022-12-20 Saint Louis University Method of treating mucopolysaccharidosis type IVA
AU2014243749A1 (en) 2013-03-13 2015-08-06 Shire Human Genetic Therapies, Inc. Method of characterizing lysosomal enzymes
WO2014143622A1 (en) * 2013-03-13 2014-09-18 Seattle Genetics, Inc. ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCs
WO2014201220A1 (en) * 2013-06-12 2014-12-18 The Board Of Trustees Of The University Of Illinois Methods for detecting prostate cancer
EP3019521A1 (en) 2013-07-12 2016-05-18 EMD Millipore Corporation A method of determining virus removal from a sample containing a target protein using activated carbon
US20170191041A1 (en) * 2014-07-11 2017-07-06 Biostrategies LC Materials and methods for treating disorders associated with sulfatase enzymes
US10472615B2 (en) 2016-01-21 2019-11-12 Saint Louis University Reduced immunogenic proteins for lysosomal storage disorders
WO2017189432A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
WO2019045149A1 (en) * 2017-08-31 2019-03-07 Green Cross Corporation PROCESS FOR PURIFYING SULFATASE PROTEIN
RU2763990C2 (ru) * 2020-02-19 2022-01-12 Акционерное общество "ГЕНЕРИУМ" Клетка, продуцирующая с высокой эффективностью активный белок арилсульфатазу в, и способ получения этой клетки
WO2021216460A1 (en) * 2020-04-19 2021-10-28 Figene, Llc Gene modified fibroblasts for therapeutic applications
WO2023150387A1 (en) * 2022-02-07 2023-08-10 M6P Therapeutics, Inc. Compositions comprising acid alpha glucosidase and methods of use thereof
TW202403043A (zh) * 2022-03-18 2024-01-16 美商健臻公司 重組人類酸性鞘磷脂酶醫藥組合物及方法

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Also Published As

Publication number Publication date
RU2607376C2 (ru) 2017-01-10
HUE033163T2 (en) 2017-11-28
US20120189605A1 (en) 2012-07-26
BR112013001558B1 (pt) 2022-08-16
KR20150038715A (ko) 2015-04-08
RU2013107765A (ru) 2014-08-27
CA2805673C (en) 2022-04-05
WO2012012718A2 (en) 2012-01-26
CL2013000219A1 (es) 2014-07-11
IL260282B (en) 2020-05-31
KR101949906B1 (ko) 2019-04-22
ZA201300286B (en) 2014-03-26
PE20171799A1 (es) 2017-12-28
CA3146151A1 (en) 2012-01-26
RS55669B1 (sr) 2017-06-30
EP2595650A2 (en) 2013-05-29
SMT201700106B (it) 2017-03-08
BR112013001558A2 (pt) 2020-08-04
US8765437B2 (en) 2014-07-01
SG187580A1 (en) 2013-03-28
AU2011280937B2 (en) 2016-06-09
KR101598897B1 (ko) 2016-03-03
AU2011280937A1 (en) 2013-01-31
DK2595650T3 (en) 2017-02-27
JP2013532986A (ja) 2013-08-22
AR082319A1 (es) 2012-11-28
US20140341878A1 (en) 2014-11-20
ES2616263T3 (es) 2017-06-12
CA2805673A1 (en) 2012-01-26
US8940513B2 (en) 2015-01-27
CN103037895B (zh) 2016-11-09
US9567572B2 (en) 2017-02-14
JP6030553B2 (ja) 2016-11-24
CN103037895A (zh) 2013-04-10
PE20171798A1 (es) 2017-12-28
WO2012012718A3 (en) 2012-04-05
PT2595650T (pt) 2017-02-22
EP2595650B1 (en) 2016-11-16
KR20130105605A (ko) 2013-09-25
IL260282A (en) 2018-07-31
IL224125B (en) 2019-02-28
AR119552A2 (es) 2021-12-29
CL2017000498A1 (es) 2017-11-24
CY1118934T1 (el) 2018-01-10
LT2595650T (lt) 2017-03-10
PE20131140A1 (es) 2013-10-17
HRP20170245T1 (hr) 2017-04-21
MX2013000908A (es) 2013-07-05
JP2016178950A (ja) 2016-10-13
US20160186149A1 (en) 2016-06-30
SI2595650T1 (sl) 2017-04-26
PL2595650T3 (pl) 2017-06-30

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