MX341351B - Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia. - Google Patents

Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia.

Info

Publication number
MX341351B
MX341351B MX2010011819A MX2010011819A MX341351B MX 341351 B MX341351 B MX 341351B MX 2010011819 A MX2010011819 A MX 2010011819A MX 2010011819 A MX2010011819 A MX 2010011819A MX 341351 B MX341351 B MX 341351B
Authority
MX
Mexico
Prior art keywords
epilepsy
adenosine
silk
release
epileptogenesis
Prior art date
Application number
MX2010011819A
Other languages
English (en)
Other versions
MX2010011819A (es
Inventor
L Kaplan David
Boison Detlev
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of MX2010011819A publication Critical patent/MX2010011819A/es
Publication of MX341351B publication Critical patent/MX341351B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Esta invención se relaciona a formulaciones de liberación sostenida que comprenden biopolímero de fibronía de seda y adenosina, que proporcionan una liberación focal, sostenida de adenosina en niveles terapéuticos para el tratamiento de la epilepsia y/o la prevención de la epileptogénesis. Una modalidad proporciona un implante de liberación de adenosina, basado en seda que alivia las convulsiones o previene la epileptogénesis. Otra modalidad proporciona un método para tratar la epilepsia o prevenir la epileptogénesis que comprende administrar focalmente adenosina en un sistema de suministro de adenosina basado en seda, de liberación sostenida.
MX2010011819A 2008-05-15 2009-05-15 Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia. MX341351B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5341308P 2008-05-15 2008-05-15
PCT/US2009/044117 WO2009140588A1 (en) 2008-05-15 2009-05-15 Silk polymer-based adenosine release: therapeutic potential for epilepsy

Publications (2)

Publication Number Publication Date
MX2010011819A MX2010011819A (es) 2010-11-30
MX341351B true MX341351B (es) 2016-08-17

Family

ID=41319072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010011819A MX341351B (es) 2008-05-15 2009-05-15 Liberacion de adenosina basada en polimero de seda: potencial terapeutico para la epilepsia.

Country Status (6)

Country Link
US (1) US9040073B2 (es)
EP (1) EP2299988A4 (es)
JP (1) JP5727366B2 (es)
CA (1) CA2721961A1 (es)
MX (1) MX341351B (es)
WO (1) WO2009140588A1 (es)

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Also Published As

Publication number Publication date
JP5727366B2 (ja) 2015-06-03
US20110152214A1 (en) 2011-06-23
EP2299988A1 (en) 2011-03-30
WO2009140588A1 (en) 2009-11-19
US9040073B2 (en) 2015-05-26
CA2721961A1 (en) 2009-11-19
EP2299988A4 (en) 2013-10-16
JP2011520912A (ja) 2011-07-21
MX2010011819A (es) 2010-11-30

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