MX2022011002A - Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos. - Google Patents
Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos.Info
- Publication number
- MX2022011002A MX2022011002A MX2022011002A MX2022011002A MX2022011002A MX 2022011002 A MX2022011002 A MX 2022011002A MX 2022011002 A MX2022011002 A MX 2022011002A MX 2022011002 A MX2022011002 A MX 2022011002A MX 2022011002 A MX2022011002 A MX 2022011002A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- humanized
- chimeric
- treatment
- relates
- Prior art date
Links
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente invención se relaciona con anticuerpos humanizados o quiméricos que unen CD3. Adicionalmente se relaciona con anticuerpos biespecíficos, composiciones, composiciones farmacéuticas, uso de los anticuerpos en el tratamiento de una enfermedad y método de tratamiento.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201500413 | 2015-07-15 | ||
DKPA201500414 | 2015-07-15 | ||
DKPA201500416 | 2015-07-16 | ||
PCT/EP2016/050296 WO2016110576A1 (en) | 2015-01-08 | 2016-01-08 | Bispecific antibodies against cd3 and cd20 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011002A true MX2022011002A (es) | 2022-10-07 |
Family
ID=57757079
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018000347A MX2018000347A (es) | 2015-07-15 | 2016-07-14 | Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos. |
MX2022011002A MX2022011002A (es) | 2015-07-15 | 2018-01-09 | Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018000347A MX2018000347A (es) | 2015-07-15 | 2016-07-14 | Anticuerpos de grupo de diferenciacion 3 (cd3) humanizados o quimericos. |
Country Status (14)
Country | Link |
---|---|
US (4) | US11359015B2 (es) |
EP (1) | EP3322727A1 (es) |
JP (2) | JP2018526981A (es) |
KR (1) | KR20180030635A (es) |
CN (2) | CN108368172B (es) |
AU (2) | AU2016293073B2 (es) |
BR (1) | BR112018000696A2 (es) |
CA (1) | CA2992380A1 (es) |
EA (1) | EA201890305A1 (es) |
IL (2) | IL310467A (es) |
MX (2) | MX2018000347A (es) |
NZ (1) | NZ739028A (es) |
UA (1) | UA128057C2 (es) |
WO (1) | WO2017009442A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11180572B2 (en) | 2012-07-06 | 2021-11-23 | Genmab B.V. | Dimeric protein with triple mutations |
US10465006B2 (en) | 2013-07-05 | 2019-11-05 | Genmab A/S | Humanized or chimeric CD3 antibodies |
TWI784957B (zh) | 2016-06-20 | 2022-12-01 | 英商克馬伯有限公司 | 免疫細胞介素 |
WO2018162749A1 (en) | 2017-03-09 | 2018-09-13 | Genmab A/S | Antibodies against pd-l1 |
US11668021B2 (en) | 2017-05-09 | 2023-06-06 | Yale University | Basehit, a high-throughput assay to identify proteins involved in host-microbe interaction |
EP3409322A1 (en) | 2017-06-01 | 2018-12-05 | F. Hoffmann-La Roche AG | Treatment method |
CN110831965B (zh) | 2017-06-21 | 2023-03-07 | 吉利德科学公司 | 靶向hiv gp120和cd3的多特异性抗体 |
MA52152A (fr) | 2018-03-12 | 2021-01-20 | Genmab As | Anticorps |
WO2019175658A1 (en) * | 2018-03-14 | 2019-09-19 | Novimmune Sa | Anti-cd3 epsilon antibodies and methods of use thereof |
EP3973000A4 (en) * | 2019-06-07 | 2023-09-06 | Adimab, LLC | HIGH AFFINITY ANTI-CD3 ANTIBODIES AND METHODS OF GENERATION AND USE THEREOF |
KR20220113346A (ko) * | 2019-07-29 | 2022-08-12 | 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 | 칸디다에 대한 항체 및 이의 용도 |
WO2021048423A1 (en) | 2019-09-12 | 2021-03-18 | Genmab A/S | Bispecific antibodies binding to 5t4 and cd3 for use in treatment of cancer |
CR20220521A (es) | 2020-03-18 | 2023-01-23 | Genmab As | Anticuerpos |
KR20230008775A (ko) * | 2020-05-08 | 2023-01-16 | 젠맵 에이/에스 | Cd3 및 cd20에 대한 이중특이적 항체 |
CN116437956A (zh) | 2020-09-10 | 2023-07-14 | 健玛保 | 用于治疗慢性淋巴细胞白血病的针对cd3和cd20的双特异性抗体 |
JP2023541860A (ja) | 2020-09-10 | 2023-10-04 | ジェンマブ エー/エス | びまん性大細胞型b細胞リンパ腫を治療するための併用療法におけるcd3及びcd20に対する二重特異性抗体 |
EP4221742A1 (en) | 2020-10-02 | 2023-08-09 | Genmab A/S | Antibodies capable of binding to ror2 and bispecific antibodies binding to ror2 and cd3 |
KR20240004949A (ko) | 2021-05-07 | 2024-01-11 | 젠맵 에이/에스 | B7h4 및 cd3에 결합하는 이중특이적 항체를 포함하는 제약 조성물 |
CN113527493B (zh) * | 2021-07-20 | 2023-10-27 | 广州爱思迈生物医药科技有限公司 | 一种b7-h3抗体及其应用 |
US11814437B2 (en) | 2021-10-08 | 2023-11-14 | Genmab A/S | Antibodies binding to CD30 and CD3 |
Family Cites Families (36)
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DE69830901T2 (de) | 1997-05-02 | 2006-05-24 | Genentech Inc., San Francisco | ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
DE10043437A1 (de) | 2000-09-04 | 2002-03-28 | Horst Lindhofer | Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites |
US20100081792A1 (en) | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
ES2368733T3 (es) | 2002-07-18 | 2011-11-21 | Merus B.V. | Producción recombinante de mezclas de anticuerpos. |
US7741568B2 (en) | 2005-01-13 | 2010-06-22 | The Wiremold Company | Downward facing receptacle assembly for cable raceway |
US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
AU2007229698B9 (en) | 2006-03-24 | 2012-11-08 | Merck Patent Gmbh | Engineered heterodimeric protein domains |
AT503902B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
EP2626372B1 (en) | 2007-03-29 | 2018-03-21 | Genmab A/S | Bispecific antibodies and methods for production thereof |
LT2520590T (lt) | 2007-04-03 | 2018-09-10 | Amgen Research (Munich) Gmbh | Susijusioms rūšims specifinis rišantis domenas |
US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
WO2010015792A1 (en) | 2008-08-06 | 2010-02-11 | Argenta Discovery Limited | Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors |
WO2010059315A1 (en) | 2008-11-18 | 2010-05-27 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
SI2786762T1 (sl) | 2008-12-19 | 2019-07-31 | Macrogenics, Inc. | Kovalentna diatelesa in njihove uporabe |
AU2010229705A1 (en) | 2009-03-27 | 2011-10-20 | Zymogenetics, Inc. | Compositions and methods for using multispecific-binding proteins comprising an antibody-receptor combination |
CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
KR101224468B1 (ko) | 2009-05-20 | 2013-01-23 | 주식회사 파멥신 | 신규한 형태의 이중표적항체 및 그 용도 |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
AR080794A1 (es) | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
US9150663B2 (en) | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
US9527926B2 (en) | 2010-05-14 | 2016-12-27 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
MX338953B (es) | 2010-08-16 | 2016-05-06 | Novimmune Sa | Metodos para la generacion de anticuerpos multiespecificos y multivalentes. |
AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
CN103796677B (zh) | 2011-04-20 | 2019-08-16 | 健玛保 | 针对her2和cd3的双特异性抗体 |
SG195072A1 (en) | 2011-05-21 | 2013-12-30 | Macrogenics Inc | Cd3-binding molecules capable of binding to human and non-human cd3 |
CN104114579B (zh) | 2011-10-27 | 2020-01-24 | 健玛保 | 异二聚体蛋白的生成 |
MX360109B (es) | 2012-04-20 | 2018-10-23 | Merus Nv | Metodos y medios para la produccion de moleculas de tipo ig. |
CA2915412A1 (en) * | 2012-06-14 | 2013-12-19 | Therapix Biosciences Ltd. | Humanized antibodies to cluster of differentiation 3 (cd3) |
EP2895203A4 (en) | 2012-06-15 | 2016-09-28 | Imaginab Inc | ANTIGEN BINDING CONSTRUCTIONS FOR CD3 |
US11180572B2 (en) * | 2012-07-06 | 2021-11-23 | Genmab B.V. | Dimeric protein with triple mutations |
ES2758979T3 (es) | 2012-07-06 | 2020-05-07 | Genmab Bv | Proteína dimérica con mutaciones triples |
JP6144771B2 (ja) | 2012-11-21 | 2017-06-07 | ファームアブシン インコーポレイテッド | Vegfr−2とdll4を標的とする二重標的抗体及びこれを含む薬学的組成物 |
US10465006B2 (en) | 2013-07-05 | 2019-11-05 | Genmab A/S | Humanized or chimeric CD3 antibodies |
AU2016205967B2 (en) | 2015-01-08 | 2021-11-11 | Genmab A/S | Bispecific antibodies against CD3 and CD20 |
-
2016
- 2016-07-14 UA UAA201801453A patent/UA128057C2/uk unknown
- 2016-07-14 KR KR1020187004157A patent/KR20180030635A/ko not_active Application Discontinuation
- 2016-07-14 JP JP2018501159A patent/JP2018526981A/ja active Pending
- 2016-07-14 IL IL310467A patent/IL310467A/en unknown
- 2016-07-14 BR BR112018000696A patent/BR112018000696A2/pt active Search and Examination
- 2016-07-14 AU AU2016293073A patent/AU2016293073B2/en active Active
- 2016-07-14 IL IL256562A patent/IL256562B1/en unknown
- 2016-07-14 US US15/744,317 patent/US11359015B2/en active Active
- 2016-07-14 NZ NZ739028A patent/NZ739028A/en unknown
- 2016-07-14 EP EP16739459.2A patent/EP3322727A1/en active Pending
- 2016-07-14 CN CN201680054638.0A patent/CN108368172B/zh active Active
- 2016-07-14 EA EA201890305A patent/EA201890305A1/ru unknown
- 2016-07-14 CN CN202210585379.1A patent/CN114989302A/zh active Pending
- 2016-07-14 MX MX2018000347A patent/MX2018000347A/es unknown
- 2016-07-14 WO PCT/EP2016/066845 patent/WO2017009442A1/en active Application Filing
- 2016-07-14 CA CA2992380A patent/CA2992380A1/en active Pending
-
2018
- 2018-01-09 MX MX2022011002A patent/MX2022011002A/es unknown
-
2021
- 2021-10-13 JP JP2021168124A patent/JP2022023862A/ja active Pending
-
2022
- 2022-05-09 US US17/739,934 patent/US20230027394A1/en active Pending
- 2022-05-09 US US17/739,923 patent/US20220380464A1/en active Pending
- 2022-05-09 US US17/739,940 patent/US20220389101A1/en active Pending
-
2023
- 2023-03-20 AU AU2023201733A patent/AU2023201733A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220389101A1 (en) | 2022-12-08 |
AU2016293073B2 (en) | 2022-12-22 |
JP2018526981A (ja) | 2018-09-20 |
IL256562B1 (en) | 2024-03-01 |
JP2022023862A (ja) | 2022-02-08 |
AU2016293073A1 (en) | 2018-02-01 |
US11359015B2 (en) | 2022-06-14 |
US20190284278A1 (en) | 2019-09-19 |
BR112018000696A2 (pt) | 2018-09-18 |
NZ739028A (en) | 2023-05-26 |
IL310467A (en) | 2024-03-01 |
CA2992380A1 (en) | 2017-01-19 |
WO2017009442A1 (en) | 2017-01-19 |
UA128057C2 (uk) | 2024-03-27 |
US20230027394A1 (en) | 2023-01-26 |
KR20180030635A (ko) | 2018-03-23 |
CN108368172B (zh) | 2022-06-14 |
CN108368172A (zh) | 2018-08-03 |
IL256562A (en) | 2018-02-28 |
US20220380464A1 (en) | 2022-12-01 |
MX2018000347A (es) | 2018-03-14 |
CN114989302A (zh) | 2022-09-02 |
EA201890305A1 (ru) | 2018-07-31 |
AU2023201733A1 (en) | 2023-07-13 |
EP3322727A1 (en) | 2018-05-23 |
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