MX2021013105A - Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb). - Google Patents
Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb).Info
- Publication number
- MX2021013105A MX2021013105A MX2021013105A MX2021013105A MX2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A MX 2021013105 A MX2021013105 A MX 2021013105A
- Authority
- MX
- Mexico
- Prior art keywords
- hbv
- hepatitis
- virus
- novel
- piperazines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención se refiere, en general, a nuevos agentes antivíricos. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19172008 | 2019-04-30 | ||
EP19172402 | 2019-05-02 | ||
PCT/EP2020/061920 WO2020221811A1 (en) | 2019-04-30 | 2020-04-29 | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021013105A true MX2021013105A (es) | 2021-11-17 |
Family
ID=70456795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021013105A MX2021013105A (es) | 2019-04-30 | 2020-04-29 | Nuevas oxalil piperazinas activas contra el virus de la hepatitis b (vhb). |
Country Status (17)
Country | Link |
---|---|
US (1) | US20220227737A1 (es) |
EP (1) | EP3962909B1 (es) |
JP (1) | JP2022533008A (es) |
KR (1) | KR20220003023A (es) |
CN (1) | CN113748111A (es) |
AU (1) | AU2020266258A1 (es) |
BR (1) | BR112021021652A2 (es) |
CA (1) | CA3138380A1 (es) |
CL (1) | CL2021002798A1 (es) |
CU (1) | CU20210090A7 (es) |
EC (1) | ECSP21080338A (es) |
IL (1) | IL287269A (es) |
MX (1) | MX2021013105A (es) |
SG (1) | SG11202111493WA (es) |
TW (1) | TWI753418B (es) |
UY (1) | UY38684A (es) |
WO (1) | WO2020221811A1 (es) |
Family Cites Families (53)
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DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
AU4289100A (en) | 1999-03-25 | 2000-10-16 | Bayer Aktiengesellschaft | Dihydropyrimidines and their use in the treatment of hepatitis |
AU768560B2 (en) | 1999-04-23 | 2003-12-18 | Extenday Ip Limited | Sheet fastening and anchoring component |
WO2001045712A1 (de) | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Arzneimittelkombinationen gegen virale erkrankungen |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
PT2690101E (pt) * | 2007-12-19 | 2015-10-08 | Genentech Inc | 5-anilinoimidazopiridinas e métodos de utilização |
CN106166157B (zh) | 2011-07-01 | 2019-08-02 | 巴鲁·S·布隆伯格研究所 | 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 |
TWI622578B (zh) | 2011-12-21 | 2018-05-01 | 諾維拉治療公司 | B型肝炎抗病毒劑 |
US9233933B2 (en) | 2012-01-06 | 2016-01-12 | Janssen Sciences Ireland Uc | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis B |
UA115069C2 (uk) | 2012-08-28 | 2017-09-11 | ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі | Конденсовані біциклічні похідні сульфамоїлу та їх застосування як лікарських препаратів для лікування гепатиту b |
BR112015004192B1 (pt) | 2012-08-28 | 2021-02-09 | Janssen Sciences Ireland Uc | sulfamoíl-arilamidas, composição farmacêutica que os compreende e uso das mesmas no tratamento da hepatite b |
WO2014165128A2 (en) | 2013-03-12 | 2014-10-09 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
WO2014184328A1 (en) | 2013-05-17 | 2014-11-20 | F. Hoffmann-La Roche Ag | 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
EA035500B1 (ru) | 2013-05-17 | 2020-06-25 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b |
EP3357906B1 (en) | 2013-07-25 | 2019-12-04 | Janssen Sciences Ireland Unlimited Company | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
CA2927560A1 (en) | 2013-10-18 | 2015-04-23 | Indiana University Research And Technology Corporation | Hepatitis b viral assembly effectors |
EA201690979A1 (ru) | 2013-11-14 | 2016-08-31 | Новира Терапьютикс, Инк. | Производные азепана и способы лечения инфекций гепатита в |
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NZ721520A (en) | 2014-03-07 | 2023-03-31 | Hoffmann La Roche | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
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2020
- 2020-04-29 US US17/607,430 patent/US20220227737A1/en active Pending
- 2020-04-29 JP JP2021564290A patent/JP2022533008A/ja active Pending
- 2020-04-29 CN CN202080032036.1A patent/CN113748111A/zh active Pending
- 2020-04-29 MX MX2021013105A patent/MX2021013105A/es unknown
- 2020-04-29 BR BR112021021652A patent/BR112021021652A2/pt unknown
- 2020-04-29 CU CU2021000090A patent/CU20210090A7/es unknown
- 2020-04-29 CA CA3138380A patent/CA3138380A1/en active Pending
- 2020-04-29 KR KR1020217038550A patent/KR20220003023A/ko unknown
- 2020-04-29 AU AU2020266258A patent/AU2020266258A1/en not_active Abandoned
- 2020-04-29 WO PCT/EP2020/061920 patent/WO2020221811A1/en unknown
- 2020-04-29 EP EP20721247.3A patent/EP3962909B1/en active Active
- 2020-04-29 SG SG11202111493WA patent/SG11202111493WA/en unknown
- 2020-04-30 TW TW109114651A patent/TWI753418B/zh active
- 2020-05-04 UY UY0001038684A patent/UY38684A/es unknown
-
2021
- 2021-10-14 IL IL287269A patent/IL287269A/en unknown
- 2021-10-25 CL CL2021002798A patent/CL2021002798A1/es unknown
- 2021-11-12 EC ECSENADI202180338A patent/ECSP21080338A/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2020221811A1 (en) | 2020-11-05 |
CL2021002798A1 (es) | 2022-06-10 |
CN113748111A (zh) | 2021-12-03 |
SG11202111493WA (en) | 2021-11-29 |
JP2022533008A (ja) | 2022-07-21 |
CA3138380A1 (en) | 2020-11-05 |
ECSP21080338A (es) | 2021-12-30 |
US20220227737A1 (en) | 2022-07-21 |
EP3962909B1 (en) | 2023-10-04 |
IL287269A (en) | 2021-12-01 |
AU2020266258A2 (en) | 2022-05-05 |
CU20210090A7 (es) | 2022-06-06 |
EP3962909A1 (en) | 2022-03-09 |
UY38684A (es) | 2020-11-30 |
KR20220003023A (ko) | 2022-01-07 |
BR112021021652A2 (pt) | 2021-12-21 |
AU2020266258A1 (en) | 2021-12-23 |
TWI753418B (zh) | 2022-01-21 |
TW202106678A (zh) | 2021-02-16 |
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