MX2021005593A - Miméticos de interleucina dividida y sus usos. - Google Patents
Miméticos de interleucina dividida y sus usos.Info
- Publication number
- MX2021005593A MX2021005593A MX2021005593A MX2021005593A MX2021005593A MX 2021005593 A MX2021005593 A MX 2021005593A MX 2021005593 A MX2021005593 A MX 2021005593A MX 2021005593 A MX2021005593 A MX 2021005593A MX 2021005593 A MX2021005593 A MX 2021005593A
- Authority
- MX
- Mexico
- Prior art keywords
- mimetics
- interleukin
- split
- receptor
- conditionally active
- Prior art date
Links
- 102000015696 Interleukins Human genes 0.000 title 1
- 108010063738 Interleukins Proteins 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 abstract 3
- 229940044601 receptor agonist Drugs 0.000 abstract 3
- 102000004559 Interleukin-13 Receptors Human genes 0.000 abstract 1
- 108010017511 Interleukin-13 Receptors Proteins 0.000 abstract 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 abstract 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 abstract 1
- 239000000833 heterodimer Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen agonistas del receptor condicionalmente activo que, cuando se activan, se unen al heterodímero ß?c del receptor de IL-2 (IL-2Rß?c), heterodímero a?c del receptor de IL-4 (IL-4Ra?c), o la subunidad a del receptor de IL-13 (IL-13Ra), como componentes de los agonistas de receptor condicionalmente activos y métodos para el uso de los agonistas de receptor condicionalmente activos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862770152P | 2018-11-20 | 2018-11-20 | |
PCT/US2019/062198 WO2020106708A1 (en) | 2018-11-20 | 2019-11-19 | Split interleukin mimetics and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021005593A true MX2021005593A (es) | 2021-08-11 |
Family
ID=69500815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021005593A MX2021005593A (es) | 2018-11-20 | 2019-11-19 | Miméticos de interleucina dividida y sus usos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220017588A1 (es) |
EP (1) | EP3883956A1 (es) |
JP (1) | JP2022511390A (es) |
KR (1) | KR20210094531A (es) |
CN (1) | CN112912388A (es) |
AU (1) | AU2019384523A1 (es) |
BR (1) | BR112021008985A2 (es) |
CA (1) | CA3119472A1 (es) |
EA (1) | EA202190593A1 (es) |
IL (1) | IL283217A (es) |
MX (1) | MX2021005593A (es) |
SG (1) | SG11202103045SA (es) |
WO (1) | WO2020106708A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11202011460YA (en) | 2018-06-25 | 2020-12-30 | Univ Washington | De novo design of potent and selective interleukin mimetics |
WO2020010250A2 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
CA3210492A1 (en) * | 2021-02-05 | 2022-08-11 | Dharmacon, Inc. | Fusion proteins for crispr-based transcriptional repression |
WO2023044318A2 (en) * | 2021-09-15 | 2023-03-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
US20230295348A1 (en) * | 2022-01-24 | 2023-09-21 | Novimmune Sa | Composition and methods for the selective activation of cytokine signaling pathways |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0019638D0 (en) * | 2000-08-09 | 2000-09-27 | European Molecular Biology Lab Embl | Peptide mimetics |
IL159215A0 (en) * | 2001-06-07 | 2004-06-01 | Wyeth Corp | A solution of interleukin-13 and methods utilizing the same |
CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验*** |
WO2012059882A2 (en) | 2010-11-05 | 2012-05-10 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
US10150802B2 (en) * | 2014-04-24 | 2018-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
SG10201809628SA (en) | 2014-04-30 | 2018-11-29 | Pfizer | Anti-ptk7 antibody-drug conjugates |
JP6640834B2 (ja) * | 2014-08-11 | 2020-02-05 | デリニア, インコーポレイテッド | 自己免疫疾患の処置のために調節性t細胞を選択的に活性化させる改変il−2変異体 |
AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
AU2018226215B2 (en) | 2017-02-24 | 2019-11-21 | Philogen S.P.A. | Immunoconjugates with optimized linkers and orientation |
MX2019010804A (es) | 2017-03-15 | 2020-01-23 | Silverback Therapeutics Inc | Compuestos de benzazepina, conjugados y usos de los mismos. |
SG11202011460YA (en) * | 2018-06-25 | 2020-12-30 | Univ Washington | De novo design of potent and selective interleukin mimetics |
-
2019
- 2019-11-19 JP JP2021517768A patent/JP2022511390A/ja active Pending
- 2019-11-19 KR KR1020217014525A patent/KR20210094531A/ko unknown
- 2019-11-19 CN CN201980070569.6A patent/CN112912388A/zh active Pending
- 2019-11-19 SG SG11202103045SA patent/SG11202103045SA/en unknown
- 2019-11-19 AU AU2019384523A patent/AU2019384523A1/en active Pending
- 2019-11-19 EP EP19848950.2A patent/EP3883956A1/en active Pending
- 2019-11-19 EA EA202190593A patent/EA202190593A1/ru unknown
- 2019-11-19 BR BR112021008985-3A patent/BR112021008985A2/pt unknown
- 2019-11-19 US US17/294,807 patent/US20220017588A1/en active Pending
- 2019-11-19 CA CA3119472A patent/CA3119472A1/en active Pending
- 2019-11-19 MX MX2021005593A patent/MX2021005593A/es unknown
- 2019-11-19 WO PCT/US2019/062198 patent/WO2020106708A1/en unknown
-
2021
- 2021-05-16 IL IL283217A patent/IL283217A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3883956A1 (en) | 2021-09-29 |
WO2020106708A1 (en) | 2020-05-28 |
CN112912388A (zh) | 2021-06-04 |
US20220017588A1 (en) | 2022-01-20 |
BR112021008985A2 (pt) | 2021-10-26 |
EA202190593A1 (ru) | 2021-11-18 |
JP2022511390A (ja) | 2022-01-31 |
CA3119472A1 (en) | 2020-05-28 |
KR20210094531A (ko) | 2021-07-29 |
SG11202103045SA (en) | 2021-04-29 |
IL283217A (en) | 2021-06-30 |
AU2019384523A1 (en) | 2021-04-22 |
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