SG11202002086XA - Optical cell culture monitoring and analyte measuring system - Google Patents

Optical cell culture monitoring and analyte measuring system

Info

Publication number
SG11202002086XA
SG11202002086XA SG11202002086XA SG11202002086XA SG11202002086XA SG 11202002086X A SG11202002086X A SG 11202002086XA SG 11202002086X A SG11202002086X A SG 11202002086XA SG 11202002086X A SG11202002086X A SG 11202002086XA SG 11202002086X A SG11202002086X A SG 11202002086XA
Authority
SG
Singapore
Prior art keywords
cell culture
measuring system
optical cell
analyte measuring
culture monitoring
Prior art date
Application number
SG11202002086XA
Inventor
Scott Robertson Bickham
Ming-Jun Li
Gregory Roger Martin
Robert Raymond Raczkowski
Horst Schreiber
Todd Michael Upton
Original Assignee
Corning Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Inc filed Critical Corning Inc
Publication of SG11202002086XA publication Critical patent/SG11202002086XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M43/00—Combinations of bioreactors or fermenters with other apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/06—Means for testing the completeness of the sterilization
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106—General arrangement of respective parts
    • G01N2021/0118—Apparatus with remote processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00207—Handling bulk quantities of analyte
    • G01N2035/00227—Monitoring a process (online)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
SG11202002086XA 2017-09-07 2018-09-05 Optical cell culture monitoring and analyte measuring system SG11202002086XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762555338P 2017-09-07 2017-09-07
PCT/US2018/049459 WO2019050888A1 (en) 2017-09-07 2018-09-05 Optical cell culture monitoring and analyte measuring system

Publications (1)

Publication Number Publication Date
SG11202002086XA true SG11202002086XA (en) 2020-04-29

Family

ID=63668028

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002086XA SG11202002086XA (en) 2017-09-07 2018-09-05 Optical cell culture monitoring and analyte measuring system

Country Status (7)

Country Link
US (2) US20190376020A1 (en)
EP (1) EP3679121A1 (en)
JP (2) JP2020532993A (en)
KR (1) KR102628956B1 (en)
CN (1) CN111065726A (en)
SG (1) SG11202002086XA (en)
WO (1) WO2019050888A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020532993A (en) * 2017-09-07 2020-11-19 コーニング インコーポレイテッド Optical cell culture monitoring and sample measurement system
MX2021002279A (en) 2018-08-27 2021-05-27 Regeneron Pharma Use of raman spectroscopy in downstream purification.
WO2020112434A2 (en) 2018-11-30 2020-06-04 Corning Incorporated Compact optical imaging system for cell culture monitoring
EP4058550A1 (en) * 2019-11-14 2022-09-21 Corning Incorporated Cell culture vessels and monitoring systems for non-invasive cell culture monitoring

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1499705A2 (en) * 2002-05-01 2005-01-26 Massachusetts Institute of Technology Microfermentors for rapid screening and analysis of biochemical processes
CN1590982A (en) * 2003-09-01 2005-03-09 亚诺法生技股份有限公司 Cell automatic optical detecting system
DE102005021034B4 (en) * 2005-05-06 2012-09-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for culturing a cell culture in an automated cell culture system and automated cell culture system
US7745209B2 (en) * 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
WO2007041308A1 (en) * 2005-09-30 2007-04-12 Cellular Bioengineering, Inc. Apparatus and method for detecting activity of living cells
DE102006033326B4 (en) * 2006-07-19 2012-03-22 Holger Plettenberg culture vessel
EP1985994A1 (en) * 2007-04-27 2008-10-29 Radiometer Medical ApS An optical sensor system
FR2946157B1 (en) * 2009-06-02 2015-03-27 Commissariat Energie Atomique MICROLENTILIC IMAGING SYSTEM AND ASSOCIATED DEVICE FOR DETECTING A SAMPLE.
SG182625A1 (en) * 2010-01-20 2012-08-30 Emd Millipore Corp Cell image capturing and remote monitoring systems
JP5916475B2 (en) * 2012-03-29 2016-05-11 日本光電工業株式会社 Measurement unit mounted on cell culture container, cell culture container, and culture state monitoring system
JP2015171344A (en) * 2014-03-12 2015-10-01 オリンパス株式会社 Cell culture vessel, cell culturing apparatus, and cell culturing method
JP6691040B2 (en) * 2014-05-14 2020-04-28 オリンパス株式会社 Culture observation device
DE202014102506U1 (en) * 2014-05-28 2014-06-27 Anmelderangaben unklar / unvollständig System for monitoring at least one incubation unit
JP6504834B2 (en) * 2015-01-27 2019-04-24 株式会社日立ハイテクノロジーズ Inspection device
JP2020532993A (en) * 2017-09-07 2020-11-19 コーニング インコーポレイテッド Optical cell culture monitoring and sample measurement system
JP7234244B2 (en) * 2018-02-12 2023-03-07 コーニング インコーポレイテッド Remote monitoring system for cell culture
WO2020112434A2 (en) * 2018-11-30 2020-06-04 Corning Incorporated Compact optical imaging system for cell culture monitoring

Also Published As

Publication number Publication date
EP3679121A1 (en) 2020-07-15
KR20200045548A (en) 2020-05-04
KR102628956B1 (en) 2024-01-24
CN111065726A (en) 2020-04-24
US20230151320A1 (en) 2023-05-18
JP2020532993A (en) 2020-11-19
WO2019050888A1 (en) 2019-03-14
US20190376020A1 (en) 2019-12-12
JP2023118971A (en) 2023-08-25

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