MX2020000005A - Pirrolopirimidina que inhibe cinasa 1 reguladora de la se?al de apoptosis (ask1) y derivados de pirrolopiridina. - Google Patents
Pirrolopirimidina que inhibe cinasa 1 reguladora de la se?al de apoptosis (ask1) y derivados de pirrolopiridina.Info
- Publication number
- MX2020000005A MX2020000005A MX2020000005A MX2020000005A MX2020000005A MX 2020000005 A MX2020000005 A MX 2020000005A MX 2020000005 A MX2020000005 A MX 2020000005A MX 2020000005 A MX2020000005 A MX 2020000005A MX 2020000005 A MX2020000005 A MX 2020000005A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- pyrrolopyrimidine
- present
- pyrrolopyridine derivatives
- ask1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención está relacionada con compuestos de pirrolopirimidina de acuerdo con la Fórmula I y su uso en la profilaxis y/o el tratamiento del dolor, afecciones inflamatorias, enfermedades cardiovasculares, enfermedades neurodegenerativas, enfermedades neurológicas, complicaciones de la diabetes tipo I, el cáncer y/o enfermedades fibróticas. En un aspecto particular, los compuestos de la presente son inhibidores de ASK (cinasa 1 reguladora de la señal de apoptosis, por sus siglas en inglés). La presente invención también proporciona métodos para la producción de un compuesto de la invención, composiciones farmacéuticas que comprenden un compuesto de la invención, el uso de los compuestos en la profilaxis y/o el tratamiento del dolor, de afecciones inflamatorias, enfermedades cardiovasculares, enfermedades neurodegenerativas, enfermedades neurológicas, complicaciones de la diabetes tipo I, el cáncer y/o enfermedades fibróticas. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1711234.3A GB201711234D0 (en) | 2017-07-12 | 2017-07-12 | Pyrrolopyrimidine and pyrrolopyridine derivatives |
PCT/GB2018/051983 WO2019012284A1 (en) | 2017-07-12 | 2018-07-12 | PYRROLOPYRIMIDINE AND ASK1 INHIBITING PYRROLOPYRIDINE DERIVATIVES |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020000005A true MX2020000005A (es) | 2020-08-06 |
Family
ID=59676761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020000005A MX2020000005A (es) | 2017-07-12 | 2018-07-12 | Pirrolopirimidina que inhibe cinasa 1 reguladora de la se?al de apoptosis (ask1) y derivados de pirrolopiridina. |
Country Status (18)
Country | Link |
---|---|
US (2) | US11136325B2 (es) |
EP (1) | EP3652173A1 (es) |
JP (1) | JP7198263B2 (es) |
KR (1) | KR20200028436A (es) |
CN (1) | CN111094283A (es) |
AR (1) | AR112333A1 (es) |
AU (1) | AU2018300218B2 (es) |
BR (1) | BR112020000578A2 (es) |
CA (1) | CA3069358A1 (es) |
CO (1) | CO2020001346A2 (es) |
GB (1) | GB201711234D0 (es) |
IL (1) | IL271910B2 (es) |
MX (1) | MX2020000005A (es) |
PH (1) | PH12019502823A1 (es) |
SG (1) | SG11202000168UA (es) |
TW (1) | TWI794253B (es) |
UY (1) | UY37809A (es) |
WO (1) | WO2019012284A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201711234D0 (en) * | 2017-07-12 | 2017-08-23 | Galapagos Nv | Pyrrolopyrimidine and pyrrolopyridine derivatives |
CN111303155A (zh) * | 2020-03-13 | 2020-06-19 | 深圳大学 | 靶向pak1抑制剂及其在抗肿瘤治疗药物中的应用 |
CN111704617B (zh) * | 2020-06-15 | 2022-08-23 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
KR102635126B1 (ko) * | 2021-05-27 | 2024-02-13 | 한국과학기술연구원 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피롤로피리미딘 유도체 및 이들의 용도 |
AR126584A1 (es) * | 2021-07-28 | 2023-10-25 | Epirium Bio Inc | Inhibidores de pgdh de pirrolo[2,3-b]piridina y métodos para hacerlos y usarlos |
KR20230019801A (ko) * | 2021-08-02 | 2023-02-09 | 한국화학연구원 | 신규한 피롤로 피리미딘 유도체 화합물, 이의 제조방법, 및 이를 유효성분으로 포함하는 대사성 간질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU784878B2 (en) | 1999-12-02 | 2006-07-13 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 A2A and A3 receptors and uses thereof |
TW200306191A (en) * | 2002-02-22 | 2003-11-16 | Teijin Ltd | Pyrrolopyrimidine derivatives |
US7390625B2 (en) | 2002-11-22 | 2008-06-24 | Takeda Pharmaceutical Company Limited | Apoptosis-associated protein and use thereof |
EP2058309A4 (en) | 2006-08-04 | 2010-12-22 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
CA2672373C (en) | 2006-12-19 | 2011-08-30 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
KR20100075881A (ko) | 2007-08-31 | 2010-07-05 | 메르크 세로노 에스. 에이. | 트리아졸로피리딘 화합물 및 ask 저해제로서 이의 용도 |
EP2271646A1 (en) | 2008-03-31 | 2011-01-12 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
TWI491606B (zh) * | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
US9045485B2 (en) * | 2010-12-16 | 2015-06-02 | Convergence Pharmaceuticals Limited | ASK 1 inhibiting pyrrolopyrimidine derivatives |
GB201711234D0 (en) * | 2017-07-12 | 2017-08-23 | Galapagos Nv | Pyrrolopyrimidine and pyrrolopyridine derivatives |
-
2017
- 2017-07-12 GB GBGB1711234.3A patent/GB201711234D0/en not_active Ceased
-
2018
- 2018-07-12 JP JP2020501447A patent/JP7198263B2/ja active Active
- 2018-07-12 AR ARP180101945 patent/AR112333A1/es unknown
- 2018-07-12 CA CA3069358A patent/CA3069358A1/en active Pending
- 2018-07-12 BR BR112020000578-9A patent/BR112020000578A2/pt unknown
- 2018-07-12 AU AU2018300218A patent/AU2018300218B2/en not_active Ceased
- 2018-07-12 EP EP18745683.5A patent/EP3652173A1/en active Pending
- 2018-07-12 CN CN201880045891.9A patent/CN111094283A/zh active Pending
- 2018-07-12 UY UY0001037809A patent/UY37809A/es not_active Application Discontinuation
- 2018-07-12 WO PCT/GB2018/051983 patent/WO2019012284A1/en unknown
- 2018-07-12 MX MX2020000005A patent/MX2020000005A/es unknown
- 2018-07-12 SG SG11202000168UA patent/SG11202000168UA/en unknown
- 2018-07-12 TW TW107124084A patent/TWI794253B/zh active
- 2018-07-12 KR KR1020207004013A patent/KR20200028436A/ko not_active Application Discontinuation
- 2018-07-12 US US16/632,202 patent/US11136325B2/en active Active
-
2019
- 2019-12-13 PH PH12019502823A patent/PH12019502823A1/en unknown
-
2020
- 2020-01-08 IL IL271910A patent/IL271910B2/en unknown
- 2020-02-06 CO CONC2020/0001346A patent/CO2020001346A2/es unknown
-
2021
- 2021-09-03 US US17/466,230 patent/US20220169653A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US11136325B2 (en) | 2021-10-05 |
CN111094283A (zh) | 2020-05-01 |
IL271910B1 (en) | 2023-03-01 |
WO2019012284A1 (en) | 2019-01-17 |
JP2020530833A (ja) | 2020-10-29 |
US20220169653A1 (en) | 2022-06-02 |
PH12019502823A1 (en) | 2020-10-26 |
EP3652173A1 (en) | 2020-05-20 |
GB201711234D0 (en) | 2017-08-23 |
CA3069358A1 (en) | 2019-01-17 |
AU2018300218B2 (en) | 2021-12-16 |
BR112020000578A2 (pt) | 2020-07-14 |
UY37809A (es) | 2019-02-28 |
IL271910A (en) | 2020-02-27 |
AR112333A1 (es) | 2019-10-16 |
IL271910B2 (en) | 2023-07-01 |
AU2018300218A1 (en) | 2020-02-27 |
RU2020106289A (ru) | 2021-08-12 |
TW201908312A (zh) | 2019-03-01 |
US20200165259A1 (en) | 2020-05-28 |
TWI794253B (zh) | 2023-03-01 |
KR20200028436A (ko) | 2020-03-16 |
JP7198263B2 (ja) | 2022-12-28 |
SG11202000168UA (en) | 2020-02-27 |
RU2020106289A3 (es) | 2021-11-10 |
CO2020001346A2 (es) | 2020-05-29 |
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