MX2019014800A - Agentes de iarn para la inhibicion de la expresion de alfa-enac y metodos de uso. - Google Patents
Agentes de iarn para la inhibicion de la expresion de alfa-enac y metodos de uso.Info
- Publication number
- MX2019014800A MX2019014800A MX2019014800A MX2019014800A MX2019014800A MX 2019014800 A MX2019014800 A MX 2019014800A MX 2019014800 A MX2019014800 A MX 2019014800A MX 2019014800 A MX2019014800 A MX 2019014800A MX 2019014800 A MX2019014800 A MX 2019014800A
- Authority
- MX
- Mexico
- Prior art keywords
- enac
- alpha
- rnai agents
- methods
- inhibiting expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/333—Modified A
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen agentes de iARN, composiciones que incluyen agentes de iARN y métodos para la inhibición de un gen de alfa-ENaC (SCNN1A). Los agentes de iARN de alfa-ENaC y conjugados de agente de iARN divulgados en la presente inhiben la expresión del gen de alfa-ENaC. También se describen composiciones farmacéuticas que incluyen uno o más agentes de iARN de alfa-ENaC, opcionalmente con uno o más agentes terapéuticos adicionales. El suministro de los agentes de iARN de alfa-ENaC descritos a las células epiteliales, tales como células epiteliales pulmonares, in vivo, prevé la inhibición de la expresión del gen de alfa-ENaC y una reducción de la actividad de ENaC, lo que puede proporcionar un beneficio terapéutico a los sujetos, incluyendo sujetos humanos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762529132P | 2017-07-06 | 2017-07-06 | |
US201862631683P | 2018-02-17 | 2018-02-17 | |
US201862679549P | 2018-06-01 | 2018-06-01 | |
PCT/US2018/040874 WO2019010274A1 (en) | 2017-07-06 | 2018-07-05 | RNAI AGENTS OF INHIBITION OF ALPHA-ENAC GENE EXPRESSION AND METHODS OF USE |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019014800A true MX2019014800A (es) | 2020-02-10 |
Family
ID=64904123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019014800A MX2019014800A (es) | 2017-07-06 | 2018-07-05 | Agentes de iarn para la inhibicion de la expresion de alfa-enac y metodos de uso. |
Country Status (22)
Country | Link |
---|---|
US (3) | US10590416B2 (es) |
EP (1) | EP3649240A4 (es) |
JP (2) | JP2020526192A (es) |
KR (1) | KR20200024793A (es) |
CN (1) | CN110832077A (es) |
AU (1) | AU2018297262A1 (es) |
BR (1) | BR112019023650A2 (es) |
CA (1) | CA3061752A1 (es) |
CL (1) | CL2020000019A1 (es) |
CO (1) | CO2019014671A2 (es) |
CR (1) | CR20190572A (es) |
EC (1) | ECSP20000655A (es) |
IL (1) | IL271843A (es) |
JO (1) | JOP20190263A1 (es) |
MX (1) | MX2019014800A (es) |
PE (1) | PE20200746A1 (es) |
PH (1) | PH12019502660A1 (es) |
TN (1) | TN2019000308A1 (es) |
TW (1) | TW201919654A (es) |
UY (1) | UY37800A (es) |
WO (1) | WO2019010274A1 (es) |
ZA (1) | ZA202100643B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
WO2023116607A1 (zh) | 2021-12-21 | 2023-06-29 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
WO2024023256A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
WO2024023254A1 (en) * | 2022-07-27 | 2024-02-01 | E-Therapeutics Plc | Nucleic acid compounds |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US4426330A (en) | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
GB8824593D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5356633A (en) | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
US5665710A (en) | 1990-04-30 | 1997-09-09 | Georgetown University | Method of making liposomal oligodeoxynucleotide compositions |
JP3220180B2 (ja) | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
JP3351476B2 (ja) | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
RU2123492C1 (ru) | 1993-02-19 | 1998-12-20 | Ниппон Синяку Ко., Лтд | Производные глицерина, средство для доставки физиологически активного вещества и фармацевтическая композиция |
US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
CA2137297C (en) | 1993-12-06 | 2000-04-18 | Tsuyoshi Miyazaki | Reactive vesicle and functional substance-fixed vesicle |
US5543152A (en) | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
US5756122A (en) | 1995-06-07 | 1998-05-26 | Georgetown University | Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells |
NZ313264A (en) | 1995-08-01 | 1999-11-29 | Novartis Ag | Liposomal oligonucleotide compositions |
US5858397A (en) | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
US6218108B1 (en) | 1997-05-16 | 2001-04-17 | Research Corporation Technologies, Inc. | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor |
US6551775B1 (en) | 1997-03-11 | 2003-04-22 | Yale University | Method to diagnose and treat pathological conditions resulting from deficient ion transport such as pseudohypoaldosteronism type-1 |
CA2294988C (en) | 1997-07-01 | 2015-11-24 | Isis Pharmaceuticals Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
US5976849A (en) | 1998-02-05 | 1999-11-02 | Zeneca Limited | Human E3 ubiquitin protein ligase |
ATE408699T1 (de) | 1999-03-10 | 2008-10-15 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
CZ302719B6 (cs) | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
BR0209646A (pt) | 2001-05-16 | 2006-10-10 | Novartis Ag | genes expressos em cáncer de mama como alvos de prognósticos e terapêuticos |
AU2002364612A1 (en) | 2001-12-31 | 2003-07-24 | Algos Therapeutics, Inc. | METHODS AND MATERIALS FOR MODULATING ENaC-BETA |
WO2004011647A1 (en) | 2002-07-26 | 2004-02-05 | Chiron Corporation | Modified small interfering rna molecules and methods of use |
JP2004121218A (ja) | 2002-08-06 | 2004-04-22 | Jenokkusu Soyaku Kenkyusho:Kk | 気管支喘息または慢性閉塞性肺疾患の検査方法 |
ATE517992T1 (de) | 2002-11-14 | 2011-08-15 | Dharmacon Inc | Funktionelle und hyperfunktionelle sirna |
CA2506630A1 (en) | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | Heart failure gene determination and therapeutic screening |
DE10305213A1 (de) | 2003-02-07 | 2004-08-26 | Florian Prof. Dr.med. Lang | Verwendung eines neuen Polymorphismus im hsgk1-Gen zur Diagnose der Hypertonie und Verwendung der sgk-Genfamilie zur Diagnose und Therapie des Long-Q/T-Syndroms |
CA2520028A1 (en) | 2003-03-31 | 2004-10-21 | University Of Iowa Research Foundation | Compounds and methods to enhance raav transduction |
US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
WO2004094636A1 (en) | 2003-04-24 | 2004-11-04 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
US20050256071A1 (en) | 2003-07-15 | 2005-11-17 | California Institute Of Technology | Inhibitor nucleic acids |
EP1752536A4 (en) | 2004-05-11 | 2008-04-16 | Alphagen Co Ltd | POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME |
US7923206B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Method of determining a cellular response to a biological agent |
CA2590768A1 (en) | 2004-12-14 | 2006-06-22 | Alnylam Pharmaceuticals, Inc. | Rnai modulation of mll-af4 and uses thereof |
EP2395012B8 (en) | 2005-11-02 | 2018-06-06 | Arbutus Biopharma Corporation | Modified siRNA molecules and uses thereof |
EP2061443A4 (en) | 2006-08-18 | 2013-07-24 | Arrowhead Res Corp | POLYCONJUGATE FOR IN VIVO ADMINISTRATION OF POLYNUCLEOTIDES |
CA2666185A1 (en) | 2006-10-11 | 2008-04-17 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Influenza targets |
AR066984A1 (es) | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
WO2010062817A1 (en) * | 2008-11-26 | 2010-06-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF EPITHELIAL SODIUM CHANNEL (ENaC) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US20130023578A1 (en) * | 2009-12-31 | 2013-01-24 | Samyang Biopharmaceuticals Corporation | siRNA for inhibition of c-Met expression and anticancer composition containing the same |
SG183374A1 (en) | 2010-02-24 | 2012-09-27 | Arrowhead Res Corp | Compositions for targeted delivery of sirna |
US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
KR20140051357A (ko) | 2011-08-26 | 2014-04-30 | 애로우헤드 리서치 코오포레이션 | In Vivo 핵산 전달용 폴리(비닐 에스테르) 고분자 |
US8933047B2 (en) | 2012-04-18 | 2015-01-13 | Arrowhead Madison Inc. | Poly(acrylate) polymers for in vivo nucleic acid delivery |
CN105392886B (zh) * | 2013-07-02 | 2019-10-22 | 印度医学研究理事会 | 用于抑制切昆贡亚病毒的RNAi剂 |
JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
PL3535397T3 (pl) | 2016-11-01 | 2022-03-07 | Arrowhead Pharmaceuticals, Inc. | Ligandy integryny alfa-v beta-6 i ich zastosowania |
TN2019000308A1 (en) * | 2017-07-06 | 2021-05-07 | Arrowhead Pharmaceuticals Inc | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE |
JP7445594B2 (ja) * | 2017-11-01 | 2024-03-07 | アローヘッド ファーマシューティカルズ インコーポレイテッド | インテグリンリガンドおよびその使用 |
US20220402947A1 (en) * | 2018-02-17 | 2022-12-22 | Arrowhead Pharmaceuticals, Inc. | Trialkyne Linking Agents and Methods of Use |
-
2018
- 2018-07-05 TN TNP/2019/000308A patent/TN2019000308A1/en unknown
- 2018-07-05 WO PCT/US2018/040874 patent/WO2019010274A1/en unknown
- 2018-07-05 PE PE2019002542A patent/PE20200746A1/es unknown
- 2018-07-05 MX MX2019014800A patent/MX2019014800A/es unknown
- 2018-07-05 JP JP2019572571A patent/JP2020526192A/ja not_active Withdrawn
- 2018-07-05 CR CR20190572A patent/CR20190572A/es unknown
- 2018-07-05 US US16/028,006 patent/US10590416B2/en active Active
- 2018-07-05 CA CA3061752A patent/CA3061752A1/en active Pending
- 2018-07-05 BR BR112019023650-3A patent/BR112019023650A2/pt unknown
- 2018-07-05 EP EP18828259.4A patent/EP3649240A4/en active Pending
- 2018-07-05 CN CN201880045293.1A patent/CN110832077A/zh active Pending
- 2018-07-05 AU AU2018297262A patent/AU2018297262A1/en active Pending
- 2018-07-05 KR KR1020197038728A patent/KR20200024793A/ko not_active Application Discontinuation
- 2018-07-06 UY UY0001037800A patent/UY37800A/es not_active Application Discontinuation
- 2018-07-06 TW TW107123550A patent/TW201919654A/zh unknown
-
2019
- 2019-01-06 JO JOP/2019/0263A patent/JOP20190263A1/ar unknown
- 2019-11-25 PH PH12019502660A patent/PH12019502660A1/en unknown
- 2019-12-24 CO CONC2019/0014671A patent/CO2019014671A2/es unknown
-
2020
- 2020-01-03 CL CL2020000019A patent/CL2020000019A1/es unknown
- 2020-01-06 IL IL271843A patent/IL271843A/en unknown
- 2020-01-06 EC ECSENADI2020655A patent/ECSP20000655A/es unknown
- 2020-01-31 US US16/778,582 patent/US11214802B2/en active Active
-
2021
- 2021-01-29 ZA ZA2021/00643A patent/ZA202100643B/en unknown
- 2021-11-29 US US17/536,754 patent/US20220090077A1/en not_active Abandoned
-
2023
- 2023-09-08 JP JP2023146393A patent/JP2023158192A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112019023650A2 (pt) | 2020-06-02 |
US11214802B2 (en) | 2022-01-04 |
UY37800A (es) | 2019-01-02 |
CN110832077A (zh) | 2020-02-21 |
TN2019000308A1 (en) | 2021-05-07 |
US20220090077A1 (en) | 2022-03-24 |
AU2018297262A1 (en) | 2020-02-27 |
PE20200746A1 (es) | 2020-07-24 |
ECSP20000655A (es) | 2020-05-29 |
CO2019014671A2 (es) | 2020-01-17 |
CL2020000019A1 (es) | 2020-06-12 |
PH12019502660A1 (en) | 2020-06-08 |
CR20190572A (es) | 2020-05-23 |
WO2019010274A1 (en) | 2019-01-10 |
EP3649240A4 (en) | 2021-07-07 |
EP3649240A1 (en) | 2020-05-13 |
US20200299691A1 (en) | 2020-09-24 |
ZA202100643B (en) | 2023-03-29 |
US20190010494A1 (en) | 2019-01-10 |
US10590416B2 (en) | 2020-03-17 |
JP2020526192A (ja) | 2020-08-31 |
IL271843A (en) | 2020-02-27 |
JOP20190263A1 (ar) | 2019-11-12 |
CA3061752A1 (en) | 2019-01-10 |
JP2023158192A (ja) | 2023-10-26 |
TW201919654A (zh) | 2019-06-01 |
KR20200024793A (ko) | 2020-03-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA202106265B (en) | Compositions and methods for inhibiting gene expression of lpa | |
PH12019502660A1 (en) | RNAi AGENTS FOR INHIBITING EXPRESSION OF ALPHA-ENaC AND METHODS OF USE | |
MX2021006912A (es) | Composiciones para la administracion de agentes terapeuticos y metodos de uso y fabricacion de las mismas. | |
MX2016007111A (es) | Inhibidores de tirosina quinasa de bruton. | |
PH12016500575A1 (en) | Inhibitors of bruton`s tyrosine kinase | |
PH12015500940A1 (en) | Bruton`s tyrosine kinase inhibitors | |
TW201613919A (en) | Inhibitors of Bruton's tyrosine kinase | |
PH12015501067A1 (en) | Pyrrolopyrimidine compounds as kinase inhibitors | |
PH12014501815A1 (en) | Purinone compounds as kinase inhibitors | |
MX2021004639A (es) | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. | |
MX2017014641A (es) | Composiciones y metodos para inhibir la expresion del gen de factor inducible por hipoxia alfa (hif2alfa). | |
MX2017003246A (es) | Macropinocitosis de anticuerpos anti-cd46 humanos y agentes terapeuticos dirigidos contra el cancer. | |
JO3776B1 (ar) | التركيبات الصيدلانية لمثبط CDK4 / 6 ومثبط B-Raf | |
IN2015DN01328A (es) | ||
MX2015005993A (es) | Composiciones y metodos para el tratamiento de displasia ectodermica. | |
IN2014DN09437A (es) | ||
MX2022014231A (es) | Conjugados de anticuerpo-farmaco que se enfocan a la uparap. | |
WO2018033941A3 (en) | Pharmaceutical compositions of ibrutinib | |
WO2016030899A8 (en) | Methods of treating amyotrophic lateral scleroses | |
EA202090234A1 (ru) | СРЕДСТВА РНКи ДЛЯ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ АЛЬФА-ENaC И СПОСОБЫ ПРИМЕНЕНИЯ | |
AR112754A1 (es) | AGENTES DE iARN PARA LA INHIBICIÓN DE LA EXPRESIÓN DE a-ENaC Y MÉTODOS DE USO | |
MX2023014026A (es) | Agentes de rnai para inhibir la expresion de mucina 5ac (muc5ac), composiciones de estos y metodos de uso. | |
UA110910C2 (uk) | Карбоксамідні похідні піразолу як інгібітори тирозинкінази брутона, фармацевтична композиція на їх основі та спосіб лікування захворювань (варіанти) |