MX2019012938A - Uso del inhibidor mejorador de homologo zeste 2 (ezh2) combinado con el inhibidor tirosina cinasa de bruton (btk) en la preparacion de farmacos para tratar tumores. - Google Patents
Uso del inhibidor mejorador de homologo zeste 2 (ezh2) combinado con el inhibidor tirosina cinasa de bruton (btk) en la preparacion de farmacos para tratar tumores.Info
- Publication number
- MX2019012938A MX2019012938A MX2019012938A MX2019012938A MX2019012938A MX 2019012938 A MX2019012938 A MX 2019012938A MX 2019012938 A MX2019012938 A MX 2019012938A MX 2019012938 A MX2019012938 A MX 2019012938A MX 2019012938 A MX2019012938 A MX 2019012938A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- treating tumor
- combined
- preparing drug
- ezh2
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La presente invención se relaciona con el uso de un inhibidor de EZH2 combinado con un inhibidor de BTK en la preparación de un fármaco para tratar un tumor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710350614 | 2017-05-18 | ||
PCT/CN2018/087246 WO2018210296A1 (zh) | 2017-05-18 | 2018-05-17 | 一种ezh2抑制剂与btk抑制剂联合在制备***的药物中的用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019012938A true MX2019012938A (es) | 2019-12-16 |
Family
ID=64273344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019012938A MX2019012938A (es) | 2017-05-18 | 2018-05-17 | Uso del inhibidor mejorador de homologo zeste 2 (ezh2) combinado con el inhibidor tirosina cinasa de bruton (btk) en la preparacion de farmacos para tratar tumores. |
Country Status (12)
Country | Link |
---|---|
US (1) | US11065239B2 (es) |
EP (1) | EP3626239A4 (es) |
JP (1) | JP7125952B2 (es) |
KR (1) | KR102635949B1 (es) |
CN (1) | CN109937041B (es) |
AU (1) | AU2018269262B2 (es) |
BR (1) | BR112019023632A2 (es) |
CA (1) | CA3058241A1 (es) |
MX (1) | MX2019012938A (es) |
RU (1) | RU2762893C2 (es) |
TW (1) | TWI810185B (es) |
WO (1) | WO2018210296A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017118277A1 (zh) * | 2016-01-05 | 2017-07-13 | 江苏恒瑞医药股份有限公司 | 一种btk激酶抑制剂的结晶形式及其制备方法 |
WO2020117052A2 (en) * | 2018-12-03 | 2020-06-11 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Ezh2- fgfr inhibition in cancer |
CN111499642A (zh) * | 2019-01-31 | 2020-08-07 | 江苏恒瑞医药股份有限公司 | 吡咯并[2,3-d]哒嗪-7-酮类衍生物的可药用盐、晶型及其制备方法 |
CN110372562B (zh) | 2019-07-09 | 2021-04-06 | 上海再启生物技术有限公司 | 一种btk激酶抑制剂关键中间体的晶型及其制备方法 |
TW202114670A (zh) * | 2019-09-30 | 2021-04-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種ezh2抑制劑與cdk4/6抑制劑聯合在製備治療腫瘤藥物中的用途 |
WO2023244918A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | Quinolone bcl6 bifunctional degraders |
WO2023244917A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | 1,8-naphthyridin-2-one heterobifunctional bcl6 degraders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012223448B2 (en) * | 2011-02-28 | 2017-03-16 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
RU2014117632A (ru) * | 2011-09-30 | 2015-11-10 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Способы лечения злокачественной опухоли |
WO2013067300A1 (en) * | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Method of treatment |
UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
SG11201507265XA (en) * | 2013-04-08 | 2015-10-29 | Bayer Pharma Aktiengesllschaft | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for treating lymphomas |
MX369503B (es) * | 2013-04-08 | 2019-11-11 | Pharmacyclics Llc | Combinaciones que comprenden ibrutinib y abt-199 para tratar trastornos proliferativos de células b y métodos de uso de las mismas. |
CN105873592B (zh) * | 2013-12-06 | 2023-01-31 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
EP3122360B1 (en) | 2014-03-25 | 2020-06-17 | ONO Pharmaceutical Co., Ltd. | Prophylactic agent and/or therapeutic agent for diffuse large b-cell lymphoma |
CA2953798C (en) * | 2014-07-07 | 2019-06-11 | Eternity Bioscience Inc. | Aminopyridazinone compounds as protein kinase inhibitors |
US20160022684A1 (en) * | 2014-07-25 | 2016-01-28 | Pharmacyclics Llc | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations |
SI3378859T1 (sl) | 2015-11-19 | 2020-03-31 | Jiangsu Hengrui Medicine Co., Ltd., | Derivat benzofurana, postopek za njegovo pripravo in njegova uporaba v medicini |
-
2018
- 2018-05-17 EP EP18802340.2A patent/EP3626239A4/en active Pending
- 2018-05-17 US US16/611,969 patent/US11065239B2/en active Active
- 2018-05-17 CN CN201880004347.XA patent/CN109937041B/zh active Active
- 2018-05-17 JP JP2019561276A patent/JP7125952B2/ja active Active
- 2018-05-17 TW TW107116782A patent/TWI810185B/zh active
- 2018-05-17 RU RU2019138222A patent/RU2762893C2/ru active
- 2018-05-17 AU AU2018269262A patent/AU2018269262B2/en active Active
- 2018-05-17 BR BR112019023632-5A patent/BR112019023632A2/pt unknown
- 2018-05-17 KR KR1020197035448A patent/KR102635949B1/ko active IP Right Grant
- 2018-05-17 WO PCT/CN2018/087246 patent/WO2018210296A1/zh active Application Filing
- 2018-05-17 CA CA3058241A patent/CA3058241A1/en active Pending
- 2018-05-17 MX MX2019012938A patent/MX2019012938A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR102635949B1 (ko) | 2024-02-14 |
TWI810185B (zh) | 2023-08-01 |
AU2018269262A1 (en) | 2019-10-31 |
RU2019138222A3 (es) | 2021-07-30 |
RU2762893C2 (ru) | 2021-12-23 |
WO2018210296A1 (zh) | 2018-11-22 |
RU2019138222A (ru) | 2021-06-18 |
KR20200007851A (ko) | 2020-01-22 |
JP2020519588A (ja) | 2020-07-02 |
TW201900171A (zh) | 2019-01-01 |
AU2018269262B2 (en) | 2021-12-02 |
JP7125952B2 (ja) | 2022-08-25 |
US11065239B2 (en) | 2021-07-20 |
CN109937041B (zh) | 2022-04-12 |
CA3058241A1 (en) | 2018-11-22 |
US20210030736A1 (en) | 2021-02-04 |
EP3626239A1 (en) | 2020-03-25 |
EP3626239A4 (en) | 2021-03-10 |
BR112019023632A2 (pt) | 2020-08-18 |
CN109937041A (zh) | 2019-06-25 |
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