MX2018013565A - Métodos para tratar la leucemia mieloide aguda y mieloma múltiple usando células asesinas naturales. - Google Patents
Métodos para tratar la leucemia mieloide aguda y mieloma múltiple usando células asesinas naturales.Info
- Publication number
- MX2018013565A MX2018013565A MX2018013565A MX2018013565A MX2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A MX 2018013565 A MX2018013565 A MX 2018013565A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- methods
- myeloid leukemia
- natural killer
- acute myeloid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 210000000822 natural killer cell Anatomy 0.000 title abstract 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 title abstract 3
- 206010035226 Plasma cell myeloma Diseases 0.000 title abstract 3
- 208000034578 Multiple myelomas Diseases 0.000 title abstract 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 210000000130 stem cell Anatomy 0.000 abstract 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 2
- 230000001483 mobilizing effect Effects 0.000 abstract 2
- 230000003169 placental effect Effects 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 210000004700 fetal blood Anatomy 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 210000002826 placenta Anatomy 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C12N2501/20—Cytokines; Chemokines
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- C12N2501/20—Cytokines; Chemokines
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- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
Abstract
En la presente se proporcionan métodos para tratar la leucemia mieloide aguda (AML, por sus siglas en inglés) y el mieloma múltiple (MM) mediante la administración de una cantidad efectiva de una población celular que comprende células asesinas naturales, en donde la población celular que comprende células asesinas naturales se produce mediante un método de tres etapas que comprende el cultivo una población de células madre o progenitoras hematopoyéticas en medios que comprenden factores de movilización de células madre, por ejemplo, métodos de tres etapas para producir células NK en medios que comprenden factores de movilización de células madre que comienzan con células madre o progenitoras hematopoyéticas de células de la placenta, por ejemplo, a partir de perfusión placentaria (por ejemplo, perfusión placentaria humana) u otros tejidos, por ejemplo, sangre del cordón umbilical o sangre periférica. Además, en la presente se proporcionan métodos para usar las células NK producidas por los métodos de tres etapas que se proporcionan en la presente para suprimir la proliferación de células de leucemia mieloide aguda. En ciertas modalidades, las células NK producidas por los métodos de tres etapas descritos en el presente documento se usan en combinación con IL-2.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662333186P | 2016-05-07 | 2016-05-07 | |
US201662333187P | 2016-05-07 | 2016-05-07 | |
US201662415954P | 2016-11-01 | 2016-11-01 | |
US201662415918P | 2016-11-01 | 2016-11-01 | |
PCT/US2017/031255 WO2017196657A1 (en) | 2016-05-07 | 2017-05-05 | Methods of treating acute myeloid leukemia and multiple myeloma using natural killer cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018013565A true MX2018013565A (es) | 2019-08-21 |
Family
ID=60267345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018013565A MX2018013565A (es) | 2016-05-07 | 2017-05-05 | Métodos para tratar la leucemia mieloide aguda y mieloma múltiple usando células asesinas naturales. |
Country Status (15)
Country | Link |
---|---|
US (1) | US11180731B2 (es) |
EP (1) | EP3452063A4 (es) |
JP (2) | JP2019519486A (es) |
KR (1) | KR20190005964A (es) |
CN (1) | CN109843304A (es) |
AU (2) | AU2017262581A1 (es) |
BR (1) | BR112018072701A2 (es) |
CA (1) | CA3023239A1 (es) |
CO (1) | CO2018012923A2 (es) |
IL (1) | IL262775A (es) |
MX (1) | MX2018013565A (es) |
NZ (1) | NZ747910A (es) |
SG (2) | SG11201809858RA (es) |
WO (1) | WO2017196657A1 (es) |
ZA (1) | ZA201807431B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL276365B2 (en) * | 2018-02-01 | 2023-10-01 | Nkmax Co Ltd | A method for the production of natural killer cells and a preparation for cancer treatment |
US20220265712A1 (en) * | 2019-06-14 | 2022-08-25 | Celularity Inc. | Populations of natural killer cells for treating cancers |
CN111727961B (zh) * | 2020-08-10 | 2020-12-01 | 医微细胞生物技术(广州)有限公司 | 一种牙髓干细胞冻存液及其冻存方法 |
US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
CN114015653A (zh) * | 2021-12-15 | 2022-02-08 | 山东省齐鲁干细胞工程有限公司 | 一种冻存脐带血来源的nk细胞及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07135969A (ja) * | 1993-11-18 | 1995-05-30 | Rikagaku Kenkyusho | ナチュラルキラー細胞の前駆細胞及びその分化増殖法 |
PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
PL2686421T3 (pl) * | 2011-03-18 | 2021-05-31 | Glycostem Therapeutics B.V. | Generowanie komórek nk i progenitorów komórek nk |
AU2013212457B2 (en) * | 2012-01-27 | 2017-02-16 | Universite De Montreal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
US20150010583A1 (en) | 2012-02-08 | 2015-01-08 | Ipd-Therapeutics B.V. | Ex vivo nk cell differentiation from cd34+ hematopoietic cells |
BR112015003149A2 (pt) * | 2012-08-13 | 2017-08-08 | Anthrogenesis Corp | células natural killer e usos das mesmas. |
CN106459914B (zh) | 2014-05-15 | 2020-11-06 | 新加坡国立大学 | 经修饰的自然杀伤细胞及其用途 |
-
2017
- 2017-05-05 MX MX2018013565A patent/MX2018013565A/es unknown
- 2017-05-05 CN CN201780041903.6A patent/CN109843304A/zh active Pending
- 2017-05-05 CA CA3023239A patent/CA3023239A1/en active Pending
- 2017-05-05 KR KR1020187035673A patent/KR20190005964A/ko not_active IP Right Cessation
- 2017-05-05 NZ NZ747910A patent/NZ747910A/en unknown
- 2017-05-05 US US16/099,676 patent/US11180731B2/en active Active
- 2017-05-05 BR BR112018072701-6A patent/BR112018072701A2/pt unknown
- 2017-05-05 JP JP2018558214A patent/JP2019519486A/ja active Pending
- 2017-05-05 SG SG11201809858RA patent/SG11201809858RA/en unknown
- 2017-05-05 AU AU2017262581A patent/AU2017262581A1/en not_active Abandoned
- 2017-05-05 WO PCT/US2017/031255 patent/WO2017196657A1/en unknown
- 2017-05-05 EP EP17796602.5A patent/EP3452063A4/en active Pending
- 2017-05-05 SG SG10201912837RA patent/SG10201912837RA/en unknown
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2018
- 2018-11-05 IL IL262775A patent/IL262775A/en unknown
- 2018-11-06 ZA ZA2018/07431A patent/ZA201807431B/en unknown
- 2018-11-28 CO CONC2018/0012923A patent/CO2018012923A2/es unknown
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2022
- 2022-04-18 JP JP2022068180A patent/JP2022095927A/ja active Pending
- 2022-12-13 AU AU2022287584A patent/AU2022287584A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022095927A (ja) | 2022-06-28 |
AU2017262581A1 (en) | 2019-01-03 |
SG10201912837RA (en) | 2020-02-27 |
JP2019519486A (ja) | 2019-07-11 |
WO2017196657A1 (en) | 2017-11-16 |
AU2022287584A1 (en) | 2023-02-02 |
CA3023239A1 (en) | 2017-11-16 |
BR112018072701A2 (pt) | 2019-02-19 |
CO2018012923A2 (es) | 2018-12-14 |
US11180731B2 (en) | 2021-11-23 |
SG11201809858RA (en) | 2018-12-28 |
NZ747910A (en) | 2023-02-24 |
US20190153389A1 (en) | 2019-05-23 |
IL262775A (en) | 2018-12-31 |
KR20190005964A (ko) | 2019-01-16 |
EP3452063A1 (en) | 2019-03-13 |
EP3452063A4 (en) | 2020-01-08 |
CN109843304A (zh) | 2019-06-04 |
ZA201807431B (en) | 2021-09-29 |
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