MX2018009656A - Piperidinas halo-sustituidas como moduladores de los receptores de orexinas. - Google Patents

Piperidinas halo-sustituidas como moduladores de los receptores de orexinas.

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Publication number
MX2018009656A
MX2018009656A MX2018009656A MX2018009656A MX2018009656A MX 2018009656 A MX2018009656 A MX 2018009656A MX 2018009656 A MX2018009656 A MX 2018009656A MX 2018009656 A MX2018009656 A MX 2018009656A MX 2018009656 A MX2018009656 A MX 2018009656A
Authority
MX
Mexico
Prior art keywords
halo
disorder
receptor modulators
orexin receptor
substituted piperidines
Prior art date
Application number
MX2018009656A
Other languages
English (en)
Inventor
M Kamenecka Theodore
Holenz Jörg
Wesolowski Steven
He Yuanjun
Bürli Roland
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2018009656A publication Critical patent/MX2018009656A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente solicitud se relaciona con ciertos compuestos de piperidina halo-sustituida, composiciones farmacéuticas que contienen los mismos, y métodos de uso de los mismos, incluyendo métodos para tratar adicción a sustancias, trastorno de pánico, ansiedad, trastorno de estrés pos-traumático, dolor, depresión, trastorno efectivo estacional, un trastorno alimentario o hipertensión.
MX2018009656A 2016-02-12 2017-02-10 Piperidinas halo-sustituidas como moduladores de los receptores de orexinas. MX2018009656A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662294940P 2016-02-12 2016-02-12
US201662336102P 2016-05-13 2016-05-13
PCT/US2017/017408 WO2017139603A1 (en) 2016-02-12 2017-02-10 Halo-substituted piperidines as orexin receptor modulators

Publications (1)

Publication Number Publication Date
MX2018009656A true MX2018009656A (es) 2019-02-20

Family

ID=59563558

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MX2018009656A MX2018009656A (es) 2016-02-12 2017-02-10 Piperidinas halo-sustituidas como moduladores de los receptores de orexinas.

Country Status (32)

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US (3) US10894789B2 (es)
EP (1) EP3414241B1 (es)
JP (1) JP6883045B2 (es)
KR (1) KR20180107232A (es)
CN (1) CN109219606B (es)
AU (1) AU2017217931B2 (es)
BR (1) BR112018016446B1 (es)
CA (1) CA3013927C (es)
CL (1) CL2018002121A1 (es)
CO (1) CO2018009290A2 (es)
CR (1) CR20180429A (es)
DK (1) DK3414241T3 (es)
DO (1) DOP2018000179A (es)
EA (1) EA036542B9 (es)
ES (1) ES2923790T3 (es)
HR (1) HRP20220906T1 (es)
HU (1) HUE059280T2 (es)
IL (1) IL260788B (es)
LT (1) LT3414241T (es)
MX (1) MX2018009656A (es)
MY (1) MY195239A (es)
PH (1) PH12018501708A1 (es)
PL (1) PL3414241T3 (es)
PT (1) PT3414241T (es)
RS (1) RS63471B1 (es)
SG (1) SG11201806368VA (es)
SI (1) SI3414241T1 (es)
SV (1) SV2018005731A (es)
TN (1) TN2018000280A1 (es)
TW (1) TWI710557B (es)
WO (1) WO2017139603A1 (es)
ZA (1) ZA201805839B (es)

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MX2018009656A (es) * 2016-02-12 2019-02-20 Astrazeneca Ab Piperidinas halo-sustituidas como moduladores de los receptores de orexinas.
US11660293B2 (en) 2017-09-01 2023-05-30 Chronos Therapeutics Limited Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
US11324724B2 (en) 2017-09-28 2022-05-10 Boehringer Ingelheim International Gmbh N-(2,2-difluoroethyl)-N-[(pyrimidinylamino)propanyl]arylcarboxamides
WO2020023723A1 (en) * 2018-07-27 2020-01-30 Icahn School Of Medicine At Mount Sinai Method of treating aggression with orexin receptor antagonists
JP7085697B2 (ja) 2019-11-01 2022-06-16 ユニマテック株式会社 含フッ素ピリミジン化合物およびその製造方法

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