MX2018003388A - Agonistas del receptor farnesoide x y usos de los mismos. - Google Patents
Agonistas del receptor farnesoide x y usos de los mismos.Info
- Publication number
- MX2018003388A MX2018003388A MX2018003388A MX2018003388A MX2018003388A MX 2018003388 A MX2018003388 A MX 2018003388A MX 2018003388 A MX2018003388 A MX 2018003388A MX 2018003388 A MX2018003388 A MX 2018003388A MX 2018003388 A MX2018003388 A MX 2018003388A
- Authority
- MX
- Mexico
- Prior art keywords
- farnesoid
- receptor agonists
- compounds
- methods
- receptor
- Prior art date
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- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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Abstract
Se describen aquí compuestos que son agonistas del receptor farnesoide X, métodos para preparar tales compuestos, composiciones farmacéuticas y medicamentos que comprenden tales compuestos, y métodos para usar tales compuestos en el tratamiento de condiciones, enfermedades o trastornos asociados con la actividad del receptor farnesoide X.
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EP3350158A4 (en) | 2015-09-16 | 2019-05-08 | Metacrine, Inc. | X FARNESOID RECEPTOR AGONISTS AND USES THEREOF |
CA3055990A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
US20200131129A1 (en) * | 2017-03-15 | 2020-04-30 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
WO2018170165A1 (en) * | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
CN110637015B (zh) | 2017-03-15 | 2024-04-02 | 奥加诺沃公司 | 法尼醇x受体激动剂及其用途 |
CN110251498A (zh) * | 2018-03-12 | 2019-09-20 | 厦门大学 | 一类调节法尼醇受体活性的化合物及其用途 |
EP3704112B1 (en) | 2017-11-01 | 2023-09-27 | Bristol-Myers Squibb Company | Alkene spirocyclic compounds as farnesoid x receptor modulators |
US11370785B2 (en) | 2017-11-01 | 2022-06-28 | Bristol-Myers Squibb Company | Multicyclic compounds as farnesoid X receptor modulators |
BR112020008834A2 (pt) | 2017-11-02 | 2020-12-22 | Calico Life Sciences Llc | Moduladores da via de estresse integrada |
KR20210076910A (ko) | 2018-09-18 | 2021-06-24 | 메타크린, 인크. | 파르네소이드 x 수용체 효능제 및 그의 용도 |
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MA53661A (fr) * | 2018-09-18 | 2021-07-28 | Metacrine Inc | Agonistes du récepteur farnésoïde x pour le traitement d'une maladie |
WO2020061116A1 (en) * | 2018-09-18 | 2020-03-26 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
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MA53671A (fr) * | 2018-09-18 | 2021-07-28 | Metacrine Inc | Formes cristallines d'un agoniste du récepteur farnésoïde x |
EP3852736A4 (en) * | 2018-09-18 | 2022-05-18 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
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AR118050A1 (es) | 2019-02-15 | 2021-09-15 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x |
CN113677666A (zh) | 2019-02-15 | 2021-11-19 | 百时美施贵宝公司 | 作为类法尼醇x受体调节剂的经取代的双环化合物 |
KR20210129119A (ko) | 2019-02-15 | 2021-10-27 | 브리스톨-마이어스 스큅 컴퍼니 | 파르네소이드 x 수용체 조정제로서 유용한 치환된 아미드 화합물 |
JP2022540699A (ja) | 2019-07-18 | 2022-09-16 | ウエヌイグレックオ・ファーマ | インターフェロンの有害作用を減少させる方法 |
CA3165424A1 (en) | 2019-12-20 | 2021-06-24 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
JP2023510274A (ja) | 2020-01-15 | 2023-03-13 | アンセルム(アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル) | D型肝炎ウイルスによる感染を処置するためのfxrアゴニストの使用 |
IL296539A (en) * | 2020-03-18 | 2022-11-01 | Metacrine Inc | Agonists of the farnesoid x receptor for the treatment of the disease |
TW202143958A (zh) * | 2020-03-18 | 2021-12-01 | 美商梅塔克林公司 | 用於治療疾病之法尼醇x(farnesoid x)受體促效劑 |
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EP0656355A1 (en) | 1992-08-11 | 1995-06-07 | Wakunaga Seiyaku Kabushiki Kaisha | Biphenylmethane derivative and medicine containing the same |
ATE307798T1 (de) * | 1999-05-17 | 2005-11-15 | Novo Nordisk As | Glucagon antagonisten/inverse agonisten |
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BR0113989A (pt) * | 2000-09-25 | 2004-01-27 | Actelion Pharmaceuticals Ltd | Compostos, composições farmacêuticas, processo para a preparação de uma composição farmacêutica, e, uso de pelo menos um dos compostos |
FR2815032B1 (fr) | 2000-10-10 | 2003-08-08 | Pf Medicament | Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations |
FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
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-
2016
- 2016-09-16 AU AU2016323992A patent/AU2016323992B2/en active Active
- 2016-09-16 MX MX2018003388A patent/MX2018003388A/es unknown
- 2016-09-16 DK DK16847452.6T patent/DK3350165T3/da active
- 2016-09-16 CN CN201680066917.9A patent/CN108349893B/zh active Active
- 2016-09-16 US US15/758,707 patent/US10703712B2/en active Active
- 2016-09-16 EP EP16847452.6A patent/EP3350165B1/en active Active
- 2016-09-16 JP JP2018534463A patent/JP6905530B2/ja active Active
- 2016-09-16 CA CA2998493A patent/CA2998493A1/en active Pending
- 2016-09-16 KR KR1020187009912A patent/KR20180052678A/ko not_active Application Discontinuation
- 2016-09-16 SG SG10202110242Y patent/SG10202110242YA/en unknown
- 2016-09-16 WO PCT/US2016/052270 patent/WO2017049173A1/en active Application Filing
- 2016-09-16 EA EA201890725A patent/EA201890725A1/ru unknown
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- 2018-03-16 PH PH12018500586A patent/PH12018500586A1/en unknown
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2019
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HK1257751A1 (zh) | 2019-10-25 |
JP2018536015A (ja) | 2018-12-06 |
EP3350165A1 (en) | 2018-07-25 |
CA2998493A1 (en) | 2017-03-23 |
SG10202110242YA (en) | 2021-10-28 |
ZA201801750B (en) | 2022-09-28 |
IL258011A (en) | 2018-05-31 |
JP6905530B2 (ja) | 2021-07-21 |
US20180282263A1 (en) | 2018-10-04 |
AU2016323992A1 (en) | 2018-04-19 |
US20210032195A1 (en) | 2021-02-04 |
AU2016323992B2 (en) | 2021-05-06 |
US10703712B2 (en) | 2020-07-07 |
US20220081390A1 (en) | 2022-03-17 |
EP3350165B1 (en) | 2023-07-26 |
CN108349893A (zh) | 2018-07-31 |
CN108349893B (zh) | 2021-12-28 |
EA201890725A1 (ru) | 2018-08-31 |
IL258011B2 (en) | 2023-02-01 |
US11214538B2 (en) | 2022-01-04 |
PH12018500586A1 (en) | 2018-10-15 |
IL258011B (en) | 2022-10-01 |
WO2017049173A1 (en) | 2017-03-23 |
EP3350165A4 (en) | 2019-07-03 |
KR20180052678A (ko) | 2018-05-18 |
DK3350165T3 (da) | 2023-09-25 |
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