MX2018001576A - Piridinas y su uso en el tratamiento del cancer. - Google Patents

Piridinas y su uso en el tratamiento del cancer.

Info

Publication number
MX2018001576A
MX2018001576A MX2018001576A MX2018001576A MX2018001576A MX 2018001576 A MX2018001576 A MX 2018001576A MX 2018001576 A MX2018001576 A MX 2018001576A MX 2018001576 A MX2018001576 A MX 2018001576A MX 2018001576 A MX2018001576 A MX 2018001576A
Authority
MX
Mexico
Prior art keywords
treatment
pyridines
cancer
compounds
cancers
Prior art date
Application number
MX2018001576A
Other languages
English (en)
Inventor
Simeonov Anton
S Dexheimer Thomas
Patrick Coussens Nathan
jadhav Ajit
Chester STAFFORD William
Karen Luci Diane
Joseph MALONEY David
Original Assignee
Elias Set Jenoe Arner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elias Set Jenoe Arner filed Critical Elias Set Jenoe Arner
Publication of MX2018001576A publication Critical patent/MX2018001576A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C07D213/71—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan compuestos de la Fórmula (I)(ver formula) (I) o sales de aquellos aceptables desde el punto de vista farmacéutico, en donde L, R1, R2, R3, R4 y n tienen significados proporcionados en la descripción, en donde los compuestos son útiles en el tratamiento de tipos de cáncer.
MX2018001576A 2015-08-07 2016-08-05 Piridinas y su uso en el tratamiento del cancer. MX2018001576A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1514021.3A GB201514021D0 (en) 2015-08-07 2015-08-07 Novel Pyridines and their use in the treatment of cancer
PCT/US2016/045731 WO2017027359A1 (en) 2015-08-07 2016-08-05 Pyridines and their use in the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2018001576A true MX2018001576A (es) 2018-11-09

Family

ID=54200423

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001576A MX2018001576A (es) 2015-08-07 2016-08-05 Piridinas y su uso en el tratamiento del cancer.

Country Status (12)

Country Link
US (1) US10899710B2 (es)
EP (1) EP3331858A1 (es)
JP (1) JP6636153B2 (es)
KR (1) KR102180934B1 (es)
CN (1) CN108026044A (es)
AU (1) AU2016306276B2 (es)
CA (1) CA2995077C (es)
GB (1) GB201514021D0 (es)
MA (1) MA42915A (es)
MX (1) MX2018001576A (es)
RU (1) RU2730505C2 (es)
WO (1) WO2017027359A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201514021D0 (en) 2015-08-07 2015-09-23 Arner Elias Set Jeno Novel Pyridines and their use in the treatment of cancer
CR20180596A (es) * 2016-05-24 2019-04-09 Basf Se Uracilpiridinas herbicidas
KR20190115012A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로사이클릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
CA3051644A1 (en) 2017-02-07 2018-08-16 Oblique Therapeutics Ab Sulfinylpyridines and their use in the treatment of cancer
BR112019016223A2 (pt) 2017-02-07 2020-04-07 Oblique Therapeutics Ab piridinas substituídas por heteroarilsulfonila e uso das mesmas no tratamento de câncer
CN110382464A (zh) 2017-02-07 2019-10-25 欧比力克治疗公司 烃基磺酰基取代的吡啶和其在癌症治疗中的用途
CA3091085A1 (en) * 2018-02-12 2019-08-15 Cinda Pharma Ab Thioredoxin reductase inhibitors for use in the treatment of cancer
EP3959199A4 (en) * 2019-04-24 2023-06-28 Memorial Sloan Kettering Cancer Center Compositions and methods for treating ras-mutant cancers

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BR112019016223A2 (pt) 2017-02-07 2020-04-07 Oblique Therapeutics Ab piridinas substituídas por heteroarilsulfonila e uso das mesmas no tratamento de câncer
KR20190115012A (ko) 2017-02-07 2019-10-10 오블리크 세러퓨틱스 에이비 헤테로사이클릴설포닐-치환된 피리딘 및 암의 치료에서 이의 용도
CN110382464A (zh) 2017-02-07 2019-10-25 欧比力克治疗公司 烃基磺酰基取代的吡啶和其在癌症治疗中的用途
CA3051644A1 (en) 2017-02-07 2018-08-16 Oblique Therapeutics Ab Sulfinylpyridines and their use in the treatment of cancer

Also Published As

Publication number Publication date
AU2016306276A1 (en) 2018-02-22
US10899710B2 (en) 2021-01-26
WO2017027359A8 (en) 2017-04-20
JP2018525443A (ja) 2018-09-06
WO2017027359A1 (en) 2017-02-16
RU2730505C2 (ru) 2020-08-24
CA2995077A1 (en) 2017-02-16
JP6636153B2 (ja) 2020-01-29
MA42915A (fr) 2018-08-01
GB201514021D0 (en) 2015-09-23
CA2995077C (en) 2020-04-21
KR102180934B1 (ko) 2020-11-20
RU2018107879A (ru) 2019-09-09
AU2016306276B2 (en) 2019-08-01
RU2018107879A3 (es) 2019-09-09
KR20180035904A (ko) 2018-04-06
US20200087260A1 (en) 2020-03-19
CN108026044A (zh) 2018-05-11
EP3331858A1 (en) 2018-06-13

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