MX2016009625A - Proteinas quimericas tipo fosfatasa alcalina. - Google Patents

Proteinas quimericas tipo fosfatasa alcalina.

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Publication number
MX2016009625A
MX2016009625A MX2016009625A MX2016009625A MX2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A MX 2016009625 A MX2016009625 A MX 2016009625A
Authority
MX
Mexico
Prior art keywords
proteins
alkaline phosphatase
chimeric
chimeric alkaline
alkaline phosphatases
Prior art date
Application number
MX2016009625A
Other languages
English (en)
Other versions
MX369041B (es
Inventor
Raaben Willem
Johannes Cornelius Jonk Luigi
Jan VAN DEN BERG Erik
Luis MILLÁN José
Van Elsas Andrea
Original Assignee
Am-Pharma B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Am-Pharma B V filed Critical Am-Pharma B V
Publication of MX2016009625A publication Critical patent/MX2016009625A/es
Publication of MX369041B publication Critical patent/MX369041B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)

Abstract

La invención se refiere a la mejora de las fosfatasas alcalinas, composiciones farmacéuticas que comprenden las fosfatasas alcalinas mejoradas y el uso de las fosfatasas alcalinas mejoradas para la prevención, tratamiento o curación de enfermedades.
MX2016009625A 2014-01-24 2015-01-26 Proteinas quimericas tipo fosfatasa alcalina. MX369041B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14152526 2014-01-24
EP14188158 2014-10-08
PCT/NL2015/050048 WO2015112017A1 (en) 2014-01-24 2015-01-26 Chimeric alkaline phosphatase-like proteins

Publications (2)

Publication Number Publication Date
MX2016009625A true MX2016009625A (es) 2017-05-01
MX369041B MX369041B (es) 2019-10-25

Family

ID=52464544

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009625A MX369041B (es) 2014-01-24 2015-01-26 Proteinas quimericas tipo fosfatasa alcalina.

Country Status (22)

Country Link
US (4) US9926544B2 (es)
EP (2) EP3097189B1 (es)
JP (3) JP6940949B2 (es)
KR (1) KR102166110B1 (es)
CN (2) CN106164262B (es)
AU (1) AU2015209783B2 (es)
BR (1) BR112016017041B1 (es)
CA (1) CA2937328C (es)
DK (1) DK3097189T3 (es)
ES (1) ES2684639T3 (es)
HU (1) HUE039784T2 (es)
IL (1) IL246898B (es)
MX (1) MX369041B (es)
PE (1) PE20161442A1 (es)
PH (1) PH12016501441A1 (es)
PL (1) PL3097189T3 (es)
RU (1) RU2683635C2 (es)
SA (1) SA516371532B1 (es)
SG (1) SG11201606060WA (es)
SI (1) SI3097189T1 (es)
WO (1) WO2015112017A1 (es)
ZA (1) ZA201605028B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102166110B1 (ko) 2014-01-24 2020-10-16 에이엠-파마 비.브이. 키메라 알칼리성 포스파타제-유사 단백질
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
JP6787894B2 (ja) 2014-12-05 2020-11-18 アレクシオン ファーマシューティカルズ， インコーポレイテッド 組換えアルカリホスファターゼを用いた発作の処置
JP6868561B2 (ja) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼ欠損を有する被験者を治療する方法
MX2018002121A (es) * 2015-08-17 2018-06-18 Alexion Pharma Inc Elaboracion de fosfatasas alcalinas.
EP3368062A4 (en) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT
EP3426286A4 (en) 2016-03-08 2019-12-04 Alexion Pharmaceuticals, Inc. METHODS OF TREATING HYPOPHOSPHATASE IN CHILDREN
WO2017173413A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
EP3464573A4 (en) 2016-06-06 2020-02-19 Alexion Pharmaceuticals, Inc. IMPACT OF METAL ON THE PRODUCTION OF ALKALINE PHOSPHATASES
EP3345614A1 (en) 2017-01-05 2018-07-11 Amrif B.V. Composition comprising alkaline phosphatase for use in the treatment of arthritides
CN110719786A (zh) * 2017-03-31 2020-01-21 阿雷克森制药公司 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法
EP3737750B1 (en) 2018-01-09 2024-06-05 Theriva Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
EP3762018B1 (en) * 2018-03-08 2024-02-14 AM-Pharma B.V. Recombinant alkaline phosphatase for use in treating sepsis-associated acute kidney injury
CA3094174A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Alkaline phosphatase agents for treatment of radiation disorders
CA3094173A1 (en) 2018-03-20 2019-09-26 Synthetic Biologics, Inc. Intestinal alkaline phosphatase formulations
US11913039B2 (en) 2018-03-30 2024-02-27 Alexion Pharmaceuticals, Inc. Method for producing recombinant alkaline phosphatase
CN110499283A (zh) * 2018-05-17 2019-11-26 西安组织工程与再生医学研究所 Wnt信号通路激活剂在制备改善低碱性磷酸酯酶症干细胞成骨分化能力异常产品中的应用
EP4210731A1 (en) 2020-09-09 2023-07-19 AM-Pharma B.V. Recombinant alkaline phosphatase for use in treating acute respiratory distress syndrome

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328918D0 (en) 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
ATE157702T1 (de) 1990-02-07 1997-09-15 Abbott Lab Alkalische phosphatase mit verbesserter spezifischer aktivität zur verwendung in indikatorreagenzien
EP0584343B1 (en) 1992-03-10 1999-01-20 La Jolla Cancer Research Foundation Recombinant calf intestinal alkaline phosphatase
JPH06284885A (ja) * 1993-04-02 1994-10-11 Tosoh Corp 組換えヒト小腸アルカリフォスファタ−ゼ
WO1994027603A1 (en) 1993-06-01 1994-12-08 Cortex Pharmaceuticals, Inc. Alkaline and acid phosphatase inhibitors in treatment of neurological disorders
AU4835693A (en) 1993-08-13 1995-03-14 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
EP0732933B1 (en) 1993-11-15 2002-10-09 Celtrix Pharmaceuticals, Inc. Use of igf-1 and igfbp-3 in the manufacture of a medicament for treating a renal disorder
WO1996039203A1 (en) 1995-06-06 1996-12-12 Gensci Regeneration Laboratories, Inc. Modified osteogenic materials
FR2736065B1 (fr) 1995-06-29 1997-09-19 Commissariat Energie Atomique Phosphatases alcalines bacteriennes modifiees et leurs applications.
JP3488327B2 (ja) 1995-12-21 2004-01-19 よつ葉乳業株式会社 牛乳脂肪球膜含有画分の製造法
US20020114802A1 (en) 1998-02-10 2002-08-22 Tjellstrom Bo Arthur Einar Oral immunoglobulin treatment for inflammatory bowel disease
DE19819962A1 (de) 1998-05-05 1999-11-11 Roche Diagnostics Gmbh Hochaktive alkalische Phosphatase
JP2002533679A (ja) 1998-12-21 2002-10-08 フアーマアウエア・アイピー・ベー・ブイ アルカリホスファターゼのｌｐｓ−結合部分を使用する敗血症の診断
JP2000350596A (ja) 1999-06-11 2000-12-19 Toyobo Co Ltd 分泌性アルカリフォスファターゼの選択的活性測定方法
ATE327751T1 (de) 2000-01-31 2006-06-15 Pfizer Prod Inc Verwendung von aktivatoren des prostaglandinrezeptores 4 zur behandlung von akuter oder chronischer niereninsuffizienz
CA2415954A1 (en) 2000-07-19 2003-01-17 Kazuhiro Maeda Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
EP1191097A1 (en) 2000-09-21 2002-03-27 Leids Universitair Medisch Centrum Induction of exon skipping in eukaryotic cells
DE10101793A1 (de) 2001-01-17 2002-08-01 Manfred Nilius Verwendung von SLPI zur Behandlung chronisch-entzündlicher Darmerkrankungen
EP1370642A2 (en) 2001-01-20 2003-12-17 Cardion AG Pluripotent adult stem cells derived from regenerative tissue
EP1393734A4 (en) 2001-06-01 2006-04-12 Ajinomoto Kk DRUG AGAINST DARMER DISEASES
US7157260B2 (en) 2001-07-26 2007-01-02 Japan Science & Technology Agency Nicotianamine synthase and gene encoding the same
JP4169966B2 (ja) 2001-11-14 2008-10-22 株式会社ヤクルト本社 炎症性腸疾患予防治療剤
CN1425766A (zh) 2001-12-19 2003-06-25 复旦大学 一种多肽——人含碱性磷酸酶活性位点的蛋白－9.24和编码这种多肽的多核苷酸
US20040146907A1 (en) * 2002-11-13 2004-07-29 Genentech, Inc. Methods and compositions for detecting dysplasia
US7048914B2 (en) 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
AU2003295264A1 (en) 2002-12-23 2004-07-14 Rijksuniversiteit Groningen Modulation of the thioredoxin pathway
AU2003225410A1 (en) 2003-03-21 2004-10-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
JP4305071B2 (ja) 2003-06-30 2009-07-29 株式会社ニコン 信号補正方法
JP2005065564A (ja) 2003-08-22 2005-03-17 Hiroshi Ueda センサー蛋白質
US7157261B2 (en) 2003-10-27 2007-01-02 Canji, Inc. Rat secreted embryonic alkaline phosphatase
JP4999467B2 (ja) 2004-02-04 2012-08-15 ファルマアウェア セプシス ビー．ブイ． 粘膜関門に存在するｌｐｓを解毒するためのアルカリホスファターゼの使用
US20110142817A1 (en) 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
WO2006096527A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Nucleic acids and proteins and methods for making and using them
US20070059300A1 (en) 2005-09-12 2007-03-15 Zoltan Laboratories Llc Compounds and compositions to control abnormal cell growth
EP1965830B1 (en) 2005-12-28 2014-05-14 Zoltan Laboratories Llc Use of alkaline phosphatase to maintain healthy tissue mass in mammals
RU2006103770A (ru) * 2006-02-08 2007-08-20 Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) (Ru) Высокоактивная бактериальная щелочная фосфатаза и фрагмент днк, кодирующий щелочную фосфатазу
US20070280922A1 (en) 2006-06-06 2007-12-06 Zoltan Kiss Consulting Combinations of human proteins to enhance viability of stem cells and progenitor cells
US7718170B2 (en) 2006-08-21 2010-05-18 Essential Skincare, Llc Alkaline phosphatase compositions to reduce skin cancer
EP1952823A1 (en) 2007-01-30 2008-08-06 AM-Pharma B.V. The use of alkaline phosphatase in the treatment of reduced renal function
WO2008104199A1 (en) 2007-03-01 2008-09-04 Gelato Corporation N.V. Use of ecto-phosphatases for the treatment of (acute) myocardial infarction
EP1985697A1 (en) 2007-04-27 2008-10-29 AM-Pharma B.V. Modified phosphatases
ES2471915T3 (es) * 2007-05-11 2014-06-27 Alexion Pharma Holding Fosfatasa alcalina dirigida al hueso, kits y métodos de uso de la misma
EP2030980A1 (en) 2007-08-28 2009-03-04 AM-Pharma B.V. Mutants of lactoferrin
WO2009106368A1 (en) 2008-02-29 2009-09-03 Gelato Corporation N.V. Method for increasing the activity of the immune system of a mammal at risk of inflammatory diseases
CA2723424A1 (en) 2008-05-19 2009-11-26 Burnham Institute For Medical Research Intestinal alkaline phosphatase modulators and uses thereof
US20110206654A1 (en) 2008-08-29 2011-08-25 The General Hospital Corporation Methods of Modulating Gastrointestinal Tract Flora Levels with Alkaline Phosphatase
US9988620B2 (en) * 2010-04-30 2018-06-05 Alexion Pharmaceuticals, Inc. Methods, compositions, and kits for the treatment of matrix mineralization disorders
HUE052383T2 (hu) * 2011-06-08 2021-04-28 Am Pharma Bv Az alkalikus foszfatáz alkalmazása a vesemûködés megõrzésére
KR102166110B1 (ko) 2014-01-24 2020-10-16 에이엠-파마 비.브이. 키메라 알칼리성 포스파타제-유사 단백질
US10570380B2 (en) 2014-01-24 2020-02-25 Am-Pharma B.V. Downstream processing of an alkaline phosphatase

Also Published As

Publication number Publication date
CN111778228A (zh) 2020-10-16
CA2937328A1 (en) 2015-07-30
RU2016131879A3 (es) 2018-08-16
EP3097189A1 (en) 2016-11-30
SI3097189T1 (sl) 2018-10-30
BR112016017041B1 (pt) 2023-09-26
AU2015209783B2 (en) 2020-10-01
KR20160117487A (ko) 2016-10-10
EP3425048A1 (en) 2019-01-09
JP7408734B2 (ja) 2024-01-05
JP6940949B2 (ja) 2021-09-29
CA2937328C (en) 2022-09-27
CN106164262B (zh) 2020-08-07
IL246898A0 (en) 2016-09-29
US11746340B2 (en) 2023-09-05
JP2022160503A (ja) 2022-10-19
US20190024062A1 (en) 2019-01-24
DK3097189T3 (en) 2018-09-03
ZA201605028B (en) 2020-02-26
AU2015209783A1 (en) 2016-08-04
BR112016017041A2 (pt) 2017-10-03
US10822597B2 (en) 2020-11-03
PH12016501441A1 (en) 2016-08-22
JP2020058375A (ja) 2020-04-16
SA516371532B1 (ar) 2019-02-11
JP2017505128A (ja) 2017-02-16
US20170009216A1 (en) 2017-01-12
PE20161442A1 (es) 2017-01-12
PL3097189T3 (pl) 2018-11-30
US20210163905A1 (en) 2021-06-03
US9926544B2 (en) 2018-03-27
MX369041B (es) 2019-10-25
RU2683635C2 (ru) 2019-03-29
IL246898B (en) 2019-09-26
ES2684639T3 (es) 2018-10-03
SG11201606060WA (en) 2016-08-30
NZ722253A (en) 2021-11-26
CN106164262A (zh) 2016-11-23
EP3097189B1 (en) 2018-07-11
KR102166110B1 (ko) 2020-10-16
US20240174994A1 (en) 2024-05-30
RU2016131879A (ru) 2018-03-01
WO2015112017A1 (en) 2015-07-30
HUE039784T2 (hu) 2019-02-28

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