MX2016008595A - Expresion mejorada de proteínas. - Google Patents
Expresion mejorada de proteínas.Info
- Publication number
- MX2016008595A MX2016008595A MX2016008595A MX2016008595A MX2016008595A MX 2016008595 A MX2016008595 A MX 2016008595A MX 2016008595 A MX2016008595 A MX 2016008595A MX 2016008595 A MX2016008595 A MX 2016008595A MX 2016008595 A MX2016008595 A MX 2016008595A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- protein expression
- interest
- enhanced protein
- results
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se relaciona, generalmente, con células bacterianas que tienen una alteración genética que produce una expresión incrementada de una proteína de interés y con los métodos para preparar y usar estas células. Los aspectos de la presente invención incluyen microorganismos grampositivos, tales como las especies de Bacillus, que tienen una alteración genética que modifica la actividad de una proteína codificada por el operón ykf y resulta en la expresión mejorada de una proteína de interés.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922613P | 2013-12-31 | 2013-12-31 | |
| PCT/US2014/069019 WO2015102814A1 (en) | 2013-12-31 | 2014-12-08 | Enhanced protein expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016008595A true MX2016008595A (es) | 2016-10-28 |
Family
ID=52273531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008595A MX2016008595A (es) | 2013-12-31 | 2014-12-08 | Expresion mejorada de proteínas. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10287591B2 (es) |
| EP (1) | EP3089991B1 (es) |
| JP (1) | JP6585602B2 (es) |
| CN (1) | CN106068273B (es) |
| CA (1) | CA2935066C (es) |
| DK (1) | DK3089991T3 (es) |
| MX (1) | MX2016008595A (es) |
| WO (1) | WO2015102814A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106599611B (zh) * | 2016-12-09 | 2019-04-30 | 中南大学 | 蛋白质功能标注方法及*** |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302544A (en) | 1979-10-15 | 1981-11-24 | University Of Rochester | Asporogenous mutant of B. subtilis for use as host component of HV1 system |
| US4450235A (en) | 1982-04-21 | 1984-05-22 | Cpc International Inc. | Asporogenic mutant of bacillus subtilis useful as a host in a host-vector system |
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5310675A (en) | 1983-06-24 | 1994-05-10 | Genencor, Inc. | Procaryotic carbonyl hydrolases |
| NZ208806A (en) | 1983-07-06 | 1988-07-28 | Gist Brocades Nv | Genetic engineering of industrial microorganism species: readily-transformable host used as intermediate in transfer of dna to the industrial species; plasmids |
| US5264366A (en) | 1984-05-29 | 1993-11-23 | Genencor, Inc. | Protease deficient bacillus |
| US5700676A (en) | 1984-05-29 | 1997-12-23 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| WO1987004461A1 (en) | 1986-01-15 | 1987-07-30 | Amgen | THERMALLY STABLE AND pH STABLE SUBTILISIN ANALOGS AND METHOD FOR PRODUCTION THEREOF |
| US4980288A (en) | 1986-02-12 | 1990-12-25 | Genex Corporation | Subtilisin with increased thermal stability |
| GB8608194D0 (en) | 1986-04-03 | 1986-05-08 | Massey Ferguson Services Nv | Valve control system |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| HU213220B (en) | 1987-02-27 | 1997-03-28 | Gist Brocades Nv | Method for enhanced production of serine protease in transformed bacillus cells and production of the transformed cells |
| US4914031A (en) | 1987-04-10 | 1990-04-03 | Amgen, Inc. | Subtilisin analogs |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| PT89702B (pt) | 1988-02-11 | 1994-04-29 | Gist Brocades Nv | Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem |
| US5665587A (en) | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| DK97190D0 (da) | 1990-04-19 | 1990-04-19 | Novo Nordisk As | Oxidationsstabile detergentenzymer |
| US5482849A (en) | 1990-12-21 | 1996-01-09 | Novo Nordisk A/S | Subtilisin mutants |
| EP0583339B1 (en) | 1991-05-01 | 1998-07-08 | Novo Nordisk A/S | Stabilized enzymes and detergent compositions |
| DE4411223A1 (de) | 1994-03-31 | 1995-10-05 | Solvay Enzymes Gmbh & Co Kg | Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren |
| AR016969A1 (es) | 1997-10-23 | 2001-08-01 | Procter & Gamble | VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL |
| US6835550B1 (en) | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
| US6617148B2 (en) * | 2000-06-29 | 2003-09-09 | E. I. Du Pont De Nemours And Company | Natural promoters for gene expression and metabolic monitoring in bacillus species |
| ATE495245T1 (de) | 2002-02-15 | 2011-01-15 | Danisco Us Inc | Verbesserte proteinexpression in bacillus subtilis |
| WO2006057341A1 (ja) * | 2004-11-26 | 2006-06-01 | Kyowa Hakko Kogyo Co., Ltd. | 工業的に有用な微生物 |
| EP2210898A1 (en) * | 2006-11-29 | 2010-07-28 | Novozymes Inc. | Bacillus Licheniformis chromosome |
| US20100022861A1 (en) | 2008-07-28 | 2010-01-28 | Medtronic, Inc. | Implantable optical hemodynamic sensor including an extension member |
| AR076941A1 (es) | 2009-06-11 | 2011-07-20 | Danisco Us Inc | Cepa de bacillus para una mayor produccion de proteina |
-
2014
- 2014-12-08 MX MX2016008595A patent/MX2016008595A/es unknown
- 2014-12-08 EP EP14821382.0A patent/EP3089991B1/en active Active
- 2014-12-08 DK DK14821382T patent/DK3089991T3/da active
- 2014-12-08 CA CA2935066A patent/CA2935066C/en active Active
- 2014-12-08 WO PCT/US2014/069019 patent/WO2015102814A1/en active Application Filing
- 2014-12-08 CN CN201480076332.6A patent/CN106068273B/zh active Active
- 2014-12-08 JP JP2016544103A patent/JP6585602B2/ja active Active
- 2014-12-08 US US15/108,074 patent/US10287591B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3089991A1 (en) | 2016-11-09 |
| US20160319288A1 (en) | 2016-11-03 |
| CA2935066C (en) | 2022-06-21 |
| JP2017500879A (ja) | 2017-01-12 |
| JP6585602B2 (ja) | 2019-10-02 |
| DK3089991T3 (da) | 2019-12-02 |
| CN106068273B (zh) | 2021-01-08 |
| EP3089991B1 (en) | 2019-08-28 |
| CA2935066A1 (en) | 2015-07-09 |
| US10287591B2 (en) | 2019-05-14 |
| WO2015102814A1 (en) | 2015-07-09 |
| CN106068273A (zh) | 2016-11-02 |
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