EA201490767A1 - Кластер генов биосинтеза гризелимицина и метилгризелимицина - Google Patents

Кластер генов биосинтеза гризелимицина и метилгризелимицина

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Publication number
EA201490767A1
EA201490767A1 EA201490767A EA201490767A EA201490767A1 EA 201490767 A1 EA201490767 A1 EA 201490767A1 EA 201490767 A EA201490767 A EA 201490767A EA 201490767 A EA201490767 A EA 201490767A EA 201490767 A1 EA201490767 A1 EA 201490767A1
Authority
EA
Eurasian Patent Office
Prior art keywords
biosynthesis
genes
methylrisylimicity
grillylimicine
cluster
Prior art date
Application number
EA201490767A
Other languages
English (en)
Other versions
EA029209B1 (ru
Inventor
Марк Бренструп
Каудиа Кениг
Луиджи Тоти
Йоахим Винк
Вульф Лойшнер
Йоханн Гассенхубер
Рольф Мюллер
Зильке Венцель
Тина Бинц
Карстен Фольц
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11306400.0A external-priority patent/EP2586791A1/en
Application filed by Санофи filed Critical Санофи
Publication of EA201490767A1 publication Critical patent/EA201490767A1/ru
Publication of EA029209B1 publication Critical patent/EA029209B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Изобретение относится к кластеру генов и генам, входящим в состав кластера генов, которые вовлечены в биосинтез гризелимицина и метилгризелимицина, и к применению кластера генов, входящих в него генов, и белков, кодируемых ими, для получения агентов-антибиотиков.
EA201490767A 2011-10-12 2012-10-11 Кластер генов биосинтеза гризелимицина и метилгризелимицина EA029209B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306321 2011-10-12
EP11306400.0A EP2586791A1 (en) 2011-10-28 2011-10-28 Gene cluster for biosynthesis of griselimycin and methylgriselimycin
PCT/EP2012/070213 WO2013053857A2 (en) 2011-10-12 2012-10-11 Gene cluster for biosynthesis of griselimycin and methylgriselimycin

Publications (2)

Publication Number Publication Date
EA201490767A1 true EA201490767A1 (ru) 2014-09-30
EA029209B1 EA029209B1 (ru) 2018-02-28

Family

ID=47559376

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490767A EA029209B1 (ru) 2011-10-12 2012-10-11 Кластер генов биосинтеза гризелимицина и метилгризелимицина

Country Status (7)

Country Link
US (1) US9422566B2 (ru)
EP (1) EP2766389B1 (ru)
JP (1) JP6430250B2 (ru)
CN (1) CN104024272B (ru)
EA (1) EA029209B1 (ru)
IN (1) IN2014CN03414A (ru)
WO (1) WO2013053857A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2766389B1 (en) 2011-10-12 2017-03-29 Sanofi Gene cluster for biosynthesis of griselimycin and methylgriselimycin
WO2016196319A1 (en) * 2015-05-29 2016-12-08 Radiant Genomics, Inc. Compositions and methods for activating silent gene clusters
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
BR112018011503A2 (pt) 2015-12-07 2018-12-04 Zymergen Inc promotores da corynebacterium glutamicum
EP3478845A4 (en) 2016-06-30 2019-07-31 Zymergen, Inc. METHODS OF PRODUCING A GLUCOSE PERMEASE BANK AND USES THEREOF
WO2018005655A2 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a bacterial hemoglobin library and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2126108B1 (ru) 1971-02-25 1974-08-02 Rhone Poulenc Sa
FI107053B (fi) 1998-10-23 2001-05-31 Galilaeus Oy Nogalamysiinin biosynteesiin liittyvä geeniryhmittymä ja sen käyttö hybridiantibioottien tuotossa
ATE292684T1 (de) * 2000-10-13 2005-04-15 Ecopia Biosciences Inc Ramoplaninbiosynthesegenkluster
AR036202A1 (es) * 2001-08-06 2004-08-18 Cubist Pharm Inc Composiciones y metodos relacionados con el cluster genico biosintetico de daptomicina
CN1388252A (zh) * 2002-08-06 2003-01-01 中国医学科学院医药生物技术研究所 吸水链霉菌17997生物合成格尔德霉素的基因簇
CN102021187A (zh) * 2003-10-23 2011-04-20 上海交通大学 Fr-008聚酮抗生素生物合成相关的基因簇
CN101016533B (zh) * 2005-11-09 2010-05-19 上海医药工业研究院 一种蒽环类抗生素产生工程菌及其应用
US8609367B2 (en) * 2007-08-03 2013-12-17 Sentinella Pharmaceuticals, Inc. Genes and proteins for the biosynthesis of the lantibiotic 107891
CN101586112B (zh) * 2009-06-19 2011-06-22 中国科学院上海有机化学研究所 诺丝七肽的生物合成基因簇
EP2766389B1 (en) 2011-10-12 2017-03-29 Sanofi Gene cluster for biosynthesis of griselimycin and methylgriselimycin

Also Published As

Publication number Publication date
WO2013053857A2 (en) 2013-04-18
JP2014530609A (ja) 2014-11-20
CN104024272A (zh) 2014-09-03
IN2014CN03414A (ru) 2015-10-09
CN104024272B (zh) 2018-04-20
EP2766389A2 (en) 2014-08-20
EA029209B1 (ru) 2018-02-28
US9422566B2 (en) 2016-08-23
EP2766389B1 (en) 2017-03-29
JP6430250B2 (ja) 2018-11-28
WO2013053857A3 (en) 2013-08-01
US20140295457A1 (en) 2014-10-02

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Designated state(s): AM AZ BY KZ KG TJ TM RU