MX2015012153A - Inhibidores de la quinasa pirrolopirimidina cdk9. - Google Patents

Inhibidores de la quinasa pirrolopirimidina cdk9.

Info

Publication number
MX2015012153A
MX2015012153A MX2015012153A MX2015012153A MX2015012153A MX 2015012153 A MX2015012153 A MX 2015012153A MX 2015012153 A MX2015012153 A MX 2015012153A MX 2015012153 A MX2015012153 A MX 2015012153A MX 2015012153 A MX2015012153 A MX 2015012153A
Authority
MX
Mexico
Prior art keywords
pyrrolopyrimindine
kinase inhibitors
cdk9 kinase
compounds
formula
Prior art date
Application number
MX2015012153A
Other languages
English (en)
Inventor
Zhi-Fu Tao
Thomas Penning
Andrew J Souers
Alan S Florjancic
Rajeev Goswami
Yunsong Tong
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2015012153A publication Critical patent/MX2015012153A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describen compuestos de Fórmula (la), (ver Fórmula) en donde R1, R2 y R3 son como se definen en la descripción, y las sales farmacéuticamente aceptables de los mismos. Los compuestos se pueden usar como agentes en el tratamiento de enfermedades, incluyendo el cáncer. También se proporcionan composiciones farmacéuticas, que comprenden uno o más compuestos de Fórmula (la).
MX2015012153A 2013-03-14 2014-03-13 Inhibidores de la quinasa pirrolopirimidina cdk9. MX2015012153A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN744DE2013 2013-03-14
PCT/US2014/025670 WO2014160028A1 (en) 2013-03-14 2014-03-13 Pyrrolopyrimindine cdk9 kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2015012153A true MX2015012153A (es) 2015-12-01

Family

ID=54200318

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015012153A MX2015012153A (es) 2013-03-14 2014-03-13 Inhibidores de la quinasa pirrolopirimidina cdk9.

Country Status (9)

Country Link
US (1) US9346813B2 (es)
EP (1) EP2970299A1 (es)
JP (1) JP2016512560A (es)
CN (1) CN105189512A (es)
AU (1) AU2014244194A1 (es)
BR (1) BR112015023078A2 (es)
CA (1) CA2903538A1 (es)
MX (1) MX2015012153A (es)
WO (1) WO2014160028A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970299A1 (en) * 2013-03-14 2016-01-20 Abbvie Inc. Pyrrolopyrimindine cdk9 kinase inhibitors
RS58712B1 (sr) 2015-06-29 2019-06-28 Astrazeneca Ab Derivati policikličnih amida kao cdk9 inhibitori
CN112125911B (zh) * 2020-09-24 2022-08-09 深圳湾实验室坪山生物医药研发转化中心 Cdk9抑制剂及其制备方法与应用
CN115124537A (zh) * 2022-07-13 2022-09-30 山东大学 一种jak抑制剂巴瑞替尼的制备方法

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WO2008079918A1 (en) 2006-12-22 2008-07-03 Novartis Ag Indol-4-yl-pyrimidinyl-2-yl-amine derivatives and use thereof as cyclin dependant kinase inhibitors
MX2009008465A (es) 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
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BRPI0917791B1 (pt) 2008-08-22 2022-03-22 Novartis Ag Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação
WO2013157021A1 (en) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
EP2970299A1 (en) * 2013-03-14 2016-01-20 Abbvie Inc. Pyrrolopyrimindine cdk9 kinase inhibitors

Also Published As

Publication number Publication date
CN105189512A (zh) 2015-12-23
BR112015023078A2 (pt) 2017-07-18
EP2970299A1 (en) 2016-01-20
US9346813B2 (en) 2016-05-24
WO2014160028A1 (en) 2014-10-02
CA2903538A1 (en) 2014-10-02
US20140275004A1 (en) 2014-09-18
AU2014244194A1 (en) 2015-09-10
JP2016512560A (ja) 2016-04-28

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