MX2015016592A - Combinaciones de un anticuerpo anti-pd-l1 y un inhibidor de mek y/o un inhibidor de raf-b. - Google Patents
Combinaciones de un anticuerpo anti-pd-l1 y un inhibidor de mek y/o un inhibidor de raf-b.Info
- Publication number
- MX2015016592A MX2015016592A MX2015016592A MX2015016592A MX2015016592A MX 2015016592 A MX2015016592 A MX 2015016592A MX 2015016592 A MX2015016592 A MX 2015016592A MX 2015016592 A MX2015016592 A MX 2015016592A MX 2015016592 A MX2015016592 A MX 2015016592A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- antibody
- combinations
- mek
- pharmaceutically acceptable
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Una combinación novedosa que comprende el inhibidor de MEK N-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)6,8-dimetil-2,4 ,7-trioxo-3,4,6,7-tetrahidro-2H-pirido[4,3-d]pirimidin-1-il]fenil }acetamida, o una sal farmacéuticamente aceptable o solvato del mismo, y/o un inhibidor de la Raf-B, en particular N-{3-[5-(2-Amino-4-pirimidinil)-2-(1, 1-dimetiletil)-1,3-tiazol-4- il]-2-fluorofenil}-2,6-difluorobencenosulfonamida o una sal farmacéuticamente aceptable del mismo, y un anticuerpo anti-PD-L1; composiciones farmacéuticas que comprenden los mismos y métodos de uso de tales combinaciones y composiciones en el tratamiento de condiciones en las que la inhibición de MEK y/o Raf-B y/o la neutralización o inhibición de la interacción entre PD-L1 y su receptor, por ejemplo, PD-1, es beneficiosa, por ejemplo, cáncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830220P | 2013-06-03 | 2013-06-03 | |
| PCT/IB2014/061895 WO2014195852A1 (en) | 2013-06-03 | 2014-06-02 | Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015016592A true MX2015016592A (es) | 2016-03-16 |
Family
ID=50943361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015016592A MX2015016592A (es) | 2013-06-03 | 2014-06-02 | Combinaciones de un anticuerpo anti-pd-l1 y un inhibidor de mek y/o un inhibidor de raf-b. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20160089434A1 (es) |
| EP (1) | EP3003282A1 (es) |
| JP (1) | JP2016520643A (es) |
| KR (1) | KR20160013049A (es) |
| CN (1) | CN105658206A (es) |
| AU (3) | AU2014276440A1 (es) |
| BR (1) | BR112015028326A8 (es) |
| CA (1) | CA2909052A1 (es) |
| CL (1) | CL2015003522A1 (es) |
| HK (1) | HK1216231A1 (es) |
| MA (1) | MA38643A1 (es) |
| MX (1) | MX2015016592A (es) |
| PH (1) | PH12015502415A1 (es) |
| RU (1) | RU2015154275A (es) |
| SG (1) | SG11201509742QA (es) |
| TN (1) | TN2015000444A1 (es) |
| WO (1) | WO2014195852A1 (es) |
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| US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| RU2364596C2 (ru) | 2004-06-11 | 2009-08-20 | Джапан Тобакко Инк. | ПРОИЗВОДНЫЕ 5-АМИНО-2,4,7-ТРИОКСО-3,4,7,8-ТЕТРАГИДРО-2Н-ПИРИДО[2,3-d] ПИРИМИДИНА, ОБЛАДАЮЩИЕ ПРОТИВООПУХОЛЕВОЙ АКТИВНОСТЬЮ |
| MX2007015942A (es) | 2005-07-01 | 2008-03-07 | Medarex Inc | Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada. |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| CN102264762B (zh) | 2008-09-26 | 2018-03-27 | 达纳-法伯癌症研究公司 | 人抗pd‑1、pd‑l1和pd‑l2的抗体及其应用 |
| TWI686405B (zh) | 2008-12-09 | 2020-03-01 | 建南德克公司 | 抗ｐｄ-ｌ１抗體及其於增進ｔ細胞功能之用途 |
| DK3560498T3 (da) * | 2009-10-16 | 2022-11-14 | Novartis Ag | Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer |
| US20110280877A1 (en) | 2010-05-11 | 2011-11-17 | Koji Tamada | Inhibition of B7-H1/CD80 interaction and uses thereof |
| KR102049817B1 (ko) * | 2011-08-01 | 2019-12-02 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 mek 억제제를 사용하는 암 치료 방법 |
| BR112014012819B1 (pt) | 2011-11-28 | 2022-08-16 | Merck Patent Gmbh | Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição |
| US9212224B2 (en) | 2012-05-15 | 2015-12-15 | Bristol-Myers Squibb Company | Antibodies that bind PD-L1 and uses thereof |
-
2014
- 2014-06-02 WO PCT/IB2014/061895 patent/WO2014195852A1/en active Application Filing
- 2014-06-02 SG SG11201509742QA patent/SG11201509742QA/en unknown
- 2014-06-02 US US14/891,984 patent/US20160089434A1/en not_active Abandoned
- 2014-06-02 CA CA2909052A patent/CA2909052A1/en not_active Abandoned
- 2014-06-02 TN TN2015000444A patent/TN2015000444A1/en unknown
- 2014-06-02 MA MA38643A patent/MA38643A1/fr unknown
- 2014-06-02 EP EP14730595.7A patent/EP3003282A1/en not_active Withdrawn
- 2014-06-02 KR KR1020157034092A patent/KR20160013049A/ko not_active Application Discontinuation
- 2014-06-02 MX MX2015016592A patent/MX2015016592A/es unknown
- 2014-06-02 CN CN201480031803.1A patent/CN105658206A/zh active Pending
- 2014-06-02 RU RU2015154275A patent/RU2015154275A/ru not_active Application Discontinuation
- 2014-06-02 BR BR112015028326A patent/BR112015028326A8/pt not_active IP Right Cessation
- 2014-06-02 JP JP2016517711A patent/JP2016520643A/ja active Pending
- 2014-06-02 AU AU2014276440A patent/AU2014276440A1/en not_active Abandoned
-
2015
- 2015-10-20 PH PH12015502415A patent/PH12015502415A1/en unknown
- 2015-12-02 CL CL2015003522A patent/CL2015003522A1/es unknown
-
2016
- 2016-04-13 HK HK16104210.8A patent/HK1216231A1/zh unknown
-
2017
- 2017-05-02 AU AU2017202926A patent/AU2017202926A1/en not_active Abandoned
-
2019
- 2019-02-27 AU AU2019201366A patent/AU2019201366A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2909052A1 (en) | 2014-12-11 |
| RU2015154275A (ru) | 2017-07-17 |
| JP2016520643A (ja) | 2016-07-14 |
| EP3003282A1 (en) | 2016-04-13 |
| MA38643A1 (fr) | 2017-10-31 |
| WO2014195852A1 (en) | 2014-12-11 |
| CL2015003522A1 (es) | 2016-09-16 |
| PH12015502415A1 (en) | 2016-02-22 |
| AU2017202926A1 (en) | 2017-05-25 |
| SG11201509742QA (en) | 2015-12-30 |
| TN2015000444A1 (en) | 2017-04-06 |
| HK1216231A1 (zh) | 2016-10-28 |
| BR112015028326A8 (pt) | 2018-01-23 |
| AU2019201366A1 (en) | 2019-03-21 |
| US20160089434A1 (en) | 2016-03-31 |
| AU2014276440A1 (en) | 2015-11-05 |
| RU2015154275A3 (es) | 2018-05-11 |
| BR112015028326A2 (pt) | 2017-07-25 |
| CN105658206A (zh) | 2016-06-08 |
| KR20160013049A (ko) | 2016-02-03 |
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