MX2014001190A - Solucion inyectable de al menos insulina basal. - Google Patents

Solucion inyectable de al menos insulina basal.

Info

Publication number
MX2014001190A
MX2014001190A MX2014001190A MX2014001190A MX2014001190A MX 2014001190 A MX2014001190 A MX 2014001190A MX 2014001190 A MX2014001190 A MX 2014001190A MX 2014001190 A MX2014001190 A MX 2014001190A MX 2014001190 A MX2014001190 A MX 2014001190A
Authority
MX
Mexico
Prior art keywords
type
basal insulin
radicals
injectable solution
cooh
Prior art date
Application number
MX2014001190A
Other languages
English (en)
Inventor
Olivier Soula
GéRARD SOULA
Jeff Tonnar
Alexandre Geissler
Original Assignee
Adocia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1157291A external-priority patent/FR2978918B1/fr
Priority claimed from FR1162445A external-priority patent/FR2984749A1/fr
Application filed by Adocia filed Critical Adocia
Publication of MX2014001190A publication Critical patent/MX2014001190A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a una solución inyectable que tiene un pH de 7, y que incluye al menos un tipo de insulina basal, el pI de la cual está entre 5.8 y 8.5. La invención se refiere a una composición en la forma de una solución acuosa inyectable, el pH de la cual está entre 6.0 y 8.0, incluyendo al menos: a) un tipo de insulina basal, el punto isoeléctrico (pI) de la cual está entre 5.8 y 8.5; y b) un dextrano substituido con radicales que tienen portadores de carboxilato y radicales hidrofóbicos de las fórmulas I o II, en donde R es -OH o es seleccionado del grupo que consiste de los radicales o-(f-[A]-COOH), o-(g-[B]-k-[D])m, D que comprende al menos una cadena de alquilo que comprende al menos 8 átomos de carbono, en donde R es -OH o un radical -(f-[A]-COOH)n, y R' se selecciona del grupo que consiste de los radicales o-CH2NH- [E] (-o- [F] )t y o-C(O)NH- [E] - (o- [F])t.
MX2014001190A 2011-08-10 2012-08-09 Solucion inyectable de al menos insulina basal. MX2014001190A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161522031P 2011-08-10 2011-08-10
FR1157291A FR2978918B1 (fr) 2011-08-10 2011-08-10 Solution injectable a ph7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5
US201161579966P 2011-12-23 2011-12-23
FR1162445A FR2984749A1 (fr) 2011-12-23 2011-12-23 Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 en combinaison avec une hormone gastro-intestinale a visee therapeutique
PCT/FR2012/051880 WO2013021143A1 (fr) 2011-08-10 2012-08-09 Solution injectable d'au moins une insuline basale

Publications (1)

Publication Number Publication Date
MX2014001190A true MX2014001190A (es) 2014-05-12

Family

ID=47667929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001190A MX2014001190A (es) 2011-08-10 2012-08-09 Solucion inyectable de al menos insulina basal.

Country Status (14)

Country Link
US (3) US9089476B2 (es)
EP (2) EP3053590A1 (es)
JP (1) JP5950477B2 (es)
KR (1) KR101810055B1 (es)
CN (1) CN103889442B (es)
AU (1) AU2012293463B2 (es)
BR (1) BR112014002986A2 (es)
CA (1) CA2843586A1 (es)
DK (1) DK2741765T3 (es)
IL (1) IL230611A (es)
MX (1) MX2014001190A (es)
RU (1) RU2578460C2 (es)
WO (1) WO2013021143A1 (es)
ZA (1) ZA201400773B (es)

Families Citing this family (41)

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MX2014001190A (es) 2011-08-10 2014-05-12 Adocia Solucion inyectable de al menos insulina basal.
CN107583039A (zh) 2012-01-09 2018-01-16 阿道恰公司 Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
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FR3001895B1 (fr) * 2013-02-12 2015-07-03 Adocia Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes
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FR2985428B1 (fr) 2012-01-09 2016-05-27 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue
CA2902256A1 (en) 2012-02-17 2013-08-22 Massachusetts Institute Of Technology Self-regulated peptide hydrogel for insulin delivery
PL2919804T3 (pl) 2012-11-13 2018-07-31 Adocia Szybko działająca formulacja insuliny zawierająca podstawiony związek anionowy
SG10202112306UA (en) 2012-11-13 2021-12-30 Adocia Substituted anionic compounds consisting of a backbone consisting of a discrete number of saccharide units

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DK2741765T3 (en) 2016-06-13
US20130065826A1 (en) 2013-03-14
US20150250858A1 (en) 2015-09-10
EP2741765A1 (fr) 2014-06-18
WO2013021143A1 (fr) 2013-02-14
KR20140051384A (ko) 2014-04-30
CN103889442A (zh) 2014-06-25
BR112014002986A2 (pt) 2017-06-13
EP2741765B9 (fr) 2016-09-28
US20170182131A9 (en) 2017-06-29
IL230611A0 (en) 2014-03-31
US9089476B2 (en) 2015-07-28
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CN103889442B (zh) 2016-12-28
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RU2578460C2 (ru) 2016-03-27
EP2741765B1 (fr) 2016-03-30
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