MX2013008471A - Metodos y aparatos para la deteccion de sensibilidad al gluten y su diferenciacion de la enfermedad celiaca. - Google Patents
Metodos y aparatos para la deteccion de sensibilidad al gluten y su diferenciacion de la enfermedad celiaca.Info
- Publication number
- MX2013008471A MX2013008471A MX2013008471A MX2013008471A MX2013008471A MX 2013008471 A MX2013008471 A MX 2013008471A MX 2013008471 A MX2013008471 A MX 2013008471A MX 2013008471 A MX2013008471 A MX 2013008471A MX 2013008471 A MX2013008471 A MX 2013008471A
- Authority
- MX
- Mexico
- Prior art keywords
- gliadin
- mer
- transglutaminase
- glutenin
- antigen
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Los anticuerpos son utilizados como biomarcadores para ayudar a distinguir la reactividad y sensibilidad inmune al gluten, enfermedad celíaca silenciosa, enfermedad de Crohn y otras patologías relacionadas con el instinto de enfermedad celíaca clásica. En una clase de modalidades, sueros, saliva u otras muestras de un humano u otro animal son probados para los anticuerpos para (a) un antígeno de trigo; (b) un antígeno de gliadina; y (c) uno o más de una aglutinina de germen de trigo, una gluteomorfina, una glutenina, una glutenina des-amidada, una prodinorfina y una dinorfina. Los resultados de la prueba se consideran particularmente interesantes cuando el antígeno del trigo y el antígeno de la gliadina son ambos seleccionados del grupo que consiste de una a-gliadina-33-mer, una a-gliadina-17-mer, una ?-gliadina-15-mer, una ?-gliadina-17-mer, y una glutenina-21-mer. Las placas de prueba y kits pueden probarse ventajosamente para antígenos a por lo menos tres, cinco, siete o todas de a-gliadina, ?-gliadina, ?-gliadina, glutenina, aglutinina de germen de trigo, gluteomorfina, prodinorfinas, transglutaminasa-2, transglutaminasa-3, transglutaminasa-6 y transglutaminasa gliadina-unida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161434501P | 2011-01-20 | 2011-01-20 | |
PCT/US2012/021892 WO2012100070A2 (en) | 2011-01-20 | 2012-01-19 | Methods and apparatus for detection of gluten sensitivity, and its differentiation from celiac disease |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013008471A true MX2013008471A (es) | 2014-03-27 |
MX354089B MX354089B (es) | 2018-02-09 |
Family
ID=46516373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013008471A MX354089B (es) | 2011-01-20 | 2012-01-19 | Metodos y aparato para la deteccion de sensibilidad al gluten y su diferenciacion de la enfermedad celiaca. |
Country Status (12)
Country | Link |
---|---|
US (3) | US20120190571A1 (es) |
EP (1) | EP2666017B1 (es) |
JP (4) | JP5937106B2 (es) |
KR (2) | KR20190087665A (es) |
CN (2) | CN103430025B (es) |
AU (2) | AU2012207267C1 (es) |
BR (1) | BR112013018696A2 (es) |
CA (2) | CA3009238C (es) |
IL (2) | IL227569B (es) |
MX (1) | MX354089B (es) |
RU (2) | RU2017137415A (es) |
WO (1) | WO2012100070A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3009238C (en) * | 2011-01-20 | 2020-10-27 | Cyrex Laboratories, Llc | Methods and apparatus for detection of gluten sensitivity, and its differentiation from celiac disease |
FR3004184B1 (fr) * | 2013-02-26 | 2016-03-18 | Agronomique Inst Nat Rech | Anticorps anti-gluten desamide et utilisations. |
FR3004183A1 (fr) * | 2013-02-26 | 2014-10-10 | Agronomique Inst Nat Rech | Anticorps anti-gluten desamide et utilisations. |
KR20150003059A (ko) * | 2013-06-28 | 2015-01-08 | 김종배 | 뇨 중 글리아돌핀(Gliadorphin) 농도 측정을 위한 면역분석법 |
WO2017147378A1 (en) * | 2016-02-25 | 2017-08-31 | The Trustees Of Columbia University In The City Of New York | Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity |
EP3449254A4 (en) * | 2016-04-26 | 2020-01-15 | Biomerica Inc. | COMPOSITIONS, DEVICES AND METHODS FOR TESTING THE SENSITIVITY OF MORBUS CROHN |
TW201832726A (zh) * | 2016-11-01 | 2018-09-16 | 美商海科生醫有限責任公司 | 可基於輸入數據建議檢測之免疫檢測系統 |
CN108676863B (zh) * | 2017-05-18 | 2022-05-03 | 四川出入境检验检疫局检验检疫技术中心 | 高通量测序技术鉴定小麦面粉中乳糜泻致敏原的方法 |
CN107176974B (zh) * | 2017-06-06 | 2021-04-13 | 中国医学科学院北京协和医院 | ω-5-醇溶蛋白特异的CD4+T细胞表位及其应用 |
CN110174513A (zh) * | 2019-04-15 | 2019-08-27 | 中山大学附属第一医院 | Tgm2在制备监测克罗恩病疾病活动的生物标志物中的应用 |
CN110055235A (zh) * | 2019-05-14 | 2019-07-26 | 深圳市亚辉龙生物科技股份有限公司 | 用于转谷氨酰胺酶抗体检测的抗原及其制备方法、试剂盒及检测方法 |
JP2021084880A (ja) * | 2019-11-28 | 2021-06-03 | 国立大学法人京都大学 | ペプチド |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4208479A (en) * | 1977-07-14 | 1980-06-17 | Syva Company | Label modified immunoassays |
US6596476B1 (en) * | 1989-12-22 | 2003-07-22 | Abbott Laboratories | Hepatitis C assay |
WO1999056698A2 (en) * | 1998-05-06 | 1999-11-11 | Københavns Universitet | Treatment of celiac disease |
US6103480A (en) * | 1999-01-14 | 2000-08-15 | Immunosciences Lab, Inc. | Single blood test for detection of food allergy, candidiasis, microflora imbalance, intestinal barrier dysfunction and humoral immunodeficiencies |
ATE269543T1 (de) * | 1999-06-28 | 2004-07-15 | Immundiagnostik Ag | Diagnose der glutensensibilitätsenteropathie und anderer autoimmunerkrangungen |
GB9919452D0 (en) * | 1999-08-17 | 1999-10-20 | Osteometer Biotech As | Specific autoimmune reactions against isomerised/optically inverted epitopes:application for diagnosis of autoimmune diseases |
GB9923306D0 (en) * | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
CA2387359A1 (en) * | 1999-10-20 | 2001-04-26 | Immco Diagnostics | Immunological assay for detection of antibodies in celiac disease |
US6703208B1 (en) * | 1999-10-20 | 2004-03-09 | Immco Diagnostics | Immunological assay for detection of antibodies in celiac disease |
CU22968A1 (es) * | 2000-06-07 | 2004-07-14 | Ct Ingenieria Genetica Biotech | Procedimiento para la detección de anticuerpos anti transglutaminasa con utilidad en el diagnóstico de la enfermedad celíaca |
ATE439588T1 (de) * | 2001-05-04 | 2009-08-15 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
JP4958369B2 (ja) * | 2001-09-05 | 2012-06-20 | 日本ハム株式会社 | 食物アレルゲン、食物アレルゲンの検出方法及び食物アレルギー誘発性食品の検出方法 |
US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
US7252957B2 (en) * | 2004-02-03 | 2007-08-07 | Immunosciences Lab., Inc. | Identification of etiology of autism |
US7563864B2 (en) * | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
JP4157947B2 (ja) * | 2004-10-29 | 2008-10-01 | 国立大学法人島根大学 | 小麦依存性運動誘発アナフィラキシーの判定方法 |
EP1919952B1 (en) * | 2005-08-11 | 2016-02-17 | Matossian-Rogers Arpi | Tcr-v-beta related peptides for treatment and diagnosis of autoimmune disease |
US8071101B2 (en) * | 2005-11-03 | 2011-12-06 | Avaxia Biologics, Inc. | Antibody therapy for treatment of diseases associated with gluten intolerance |
US20090176251A1 (en) * | 2008-01-08 | 2009-07-09 | Binder Walter L | Methods for Diagnosing Celiac Disease Based on the Level of Anti-Gliadin and Anti-tTG IgA and IgG Antibodies |
US20090253154A1 (en) * | 2008-04-02 | 2009-10-08 | Immunosciences Lab., Inc. | Blood and saliva test for detection of delayed food allergy and intolerance against modified foods |
EP2367561B1 (en) * | 2008-11-30 | 2015-05-20 | Immusant, Inc. | Compositions and methods for treatment of celiac disease |
HU0900199D0 (en) * | 2009-04-01 | 2009-06-29 | Debreceni Egyetem | Diagnosis of gluten-induced autoimmune diseases |
CA3009238C (en) * | 2011-01-20 | 2020-10-27 | Cyrex Laboratories, Llc | Methods and apparatus for detection of gluten sensitivity, and its differentiation from celiac disease |
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2012
- 2012-01-19 CA CA3009238A patent/CA3009238C/en active Active
- 2012-01-19 KR KR1020197020794A patent/KR20190087665A/ko not_active Application Discontinuation
- 2012-01-19 CN CN201280014219.6A patent/CN103430025B/zh active Active
- 2012-01-19 RU RU2017137415A patent/RU2017137415A/ru unknown
- 2012-01-19 US US13/354,119 patent/US20120190571A1/en not_active Abandoned
- 2012-01-19 EP EP12737185.4A patent/EP2666017B1/en active Active
- 2012-01-19 BR BR112013018696A patent/BR112013018696A2/pt not_active Application Discontinuation
- 2012-01-19 RU RU2013138482A patent/RU2635516C2/ru active
- 2012-01-19 AU AU2012207267A patent/AU2012207267C1/en active Active
- 2012-01-19 CA CA2827669A patent/CA2827669C/en active Active
- 2012-01-19 KR KR1020137021844A patent/KR102047141B1/ko active IP Right Grant
- 2012-01-19 JP JP2013550583A patent/JP5937106B2/ja active Active
- 2012-01-19 WO PCT/US2012/021892 patent/WO2012100070A2/en active Application Filing
- 2012-01-19 CN CN201711127909.3A patent/CN107831318B/zh active Active
- 2012-01-19 MX MX2013008471A patent/MX354089B/es active IP Right Grant
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2013
- 2013-07-21 IL IL227569A patent/IL227569B/en active IP Right Grant
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2016
- 2016-05-11 JP JP2016095223A patent/JP6239685B2/ja active Active
- 2016-09-07 US US15/258,949 patent/US10627408B2/en active Active
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2017
- 2017-03-21 AU AU2017201908A patent/AU2017201908B2/en active Active
- 2017-11-01 JP JP2017211525A patent/JP6426253B2/ja active Active
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2018
- 2018-08-05 IL IL260991A patent/IL260991B/en active IP Right Grant
- 2018-10-24 JP JP2018200161A patent/JP2019035761A/ja active Pending
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2019
- 2019-11-01 US US16/671,843 patent/US20200057074A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: CYREX LABORATORIES, LLC |
|
FG | Grant or registration |