MX2012002827A - Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos. - Google Patents

Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos.

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Publication number
MX2012002827A
MX2012002827A MX2012002827A MX2012002827A MX2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A MX 2012002827 A MX2012002827 A MX 2012002827A
Authority
MX
Mexico
Prior art keywords
methods
histamine
compounds
antagonists
inverse agonists
Prior art date
Application number
MX2012002827A
Other languages
English (en)
Inventor
Qun Kevin Fang
Milan Chytil
Sharon R Engel
Original Assignee
Sunovion Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Sunovion Pharmaceuticals Inc filed Critical Sunovion Pharmaceuticals Inc
Publication of MX2012002827A publication Critical patent/MX2012002827A/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Aquí se proporciona compuestos de imidazolilo fusionados, métodos de síntesis, y métodos para usar los mismos. Los compuestos proporcionados aquí son útiles para el tratamiento, la prevención y/o el manejo de varis trastornos, incluyendo, por ejemplo, trastornos neurodegenerativos y trastornos metabólicos. Los compuestos proporcionados aquí inhiben la actividad de los receptores H3 de la histamina, y modulan la liberación de varios neurotransmisores, tales como, por ejemplo, histamina, acetilcolina, norepinefrina, y dopamina (por ejemplo, en las sinapsis). También se proporcionan aquí las composiciones farmacéuticas que contienen los compuestos y sus métodos de uso.
MX2012002827A 2009-09-11 2010-09-09 Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos. MX2012002827A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24184009P 2009-09-11 2009-09-11
PCT/US2010/048199 WO2011031816A2 (en) 2009-09-11 2010-09-09 Histamine h3 inverse agonists and antagonists and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2012002827A true MX2012002827A (es) 2012-04-10

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ID=43259785

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Application Number Title Priority Date Filing Date
MX2012002827A MX2012002827A (es) 2009-09-11 2010-09-09 Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos.
MX2012002898A MX2012002898A (es) 2009-09-11 2010-09-09 Agonistas y antagonistas inversos de histamina h3 y metodos de uso para los mismos.

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Country Status (8)

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US (2) US20110065694A1 (es)
EP (2) EP2475664A2 (es)
JP (2) JP2013504581A (es)
CN (2) CN102686586A (es)
AU (2) AU2010292285A1 (es)
CA (2) CA2772522A1 (es)
MX (2) MX2012002827A (es)
WO (2) WO2011031818A2 (es)

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KR20110132564A (ko) 2009-02-11 2011-12-08 선오비온 파마슈티컬스 인코포레이티드 히스타민 ｈ3 역 작용제 및 길항제, 및 이의 사용 방법
US20110065694A1 (en) * 2009-09-11 2011-03-17 Milan Chytil Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof
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CA2772522A1 (en) 2011-03-17
MX2012002898A (es) 2012-04-02
WO2011031818A2 (en) 2011-03-17
EP2475664A2 (en) 2012-07-18
US20120172350A1 (en) 2012-07-05
CA2772525A1 (en) 2011-03-17
JP2013504580A (ja) 2013-02-07
AU2010292285A1 (en) 2012-03-15
WO2011031816A3 (en) 2012-07-05
US20110065694A1 (en) 2011-03-17
AU2010292287A1 (en) 2012-03-15
CN102686586A (zh) 2012-09-19
CN102596955A (zh) 2012-07-18

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