BRPI0921798A2 - azepino[4,5-b]indóis e métodos de uso - Google Patents
azepino[4,5-b]indóis e métodos de usoInfo
- Publication number
- BRPI0921798A2 BRPI0921798A2 BRPI0921798A BRPI0921798A BRPI0921798A2 BR PI0921798 A2 BRPI0921798 A2 BR PI0921798A2 BR PI0921798 A BRPI0921798 A BR PI0921798A BR PI0921798 A BRPI0921798 A BR PI0921798A BR PI0921798 A2 BRPI0921798 A2 BR PI0921798A2
- Authority
- BR
- Brazil
- Prior art keywords
- azepine
- indoles
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11052708P | 2008-10-31 | 2008-10-31 | |
| US17396509P | 2009-04-29 | 2009-04-29 | |
| US24525709P | 2009-09-23 | 2009-09-23 | |
| PCT/US2009/062872 WO2010051503A1 (en) | 2008-10-31 | 2009-10-30 | Azepino [4, 5-b] indoles and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0921798A2 true BRPI0921798A2 (pt) | 2019-09-24 |
Family
ID=42129314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921798A BRPI0921798A2 (pt) | 2008-10-31 | 2009-10-30 | azepino[4,5-b]indóis e métodos de uso |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8569287B2 (pt) |
| EP (1) | EP2348847A4 (pt) |
| JP (1) | JP5551708B2 (pt) |
| CN (1) | CN102316732B (pt) |
| AR (1) | AR073924A1 (pt) |
| AU (1) | AU2009308708B2 (pt) |
| BR (1) | BRPI0921798A2 (pt) |
| CA (1) | CA2742322A1 (pt) |
| HK (1) | HK1164641A1 (pt) |
| TW (1) | TWI482773B (pt) |
| WO (1) | WO2010051503A1 (pt) |
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| RU2007139634A (ru) | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
| RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| CN102083830B (zh) | 2008-03-24 | 2014-11-12 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
| JP5586577B2 (ja) * | 2008-03-24 | 2014-09-10 | メディベイション テクノロジーズ， インコーポレイテッド | 架橋複素環化合物およびその使用 |
| JP5588991B2 (ja) | 2008-10-31 | 2014-09-10 | メディベイション テクノロジーズ， インコーポレイテッド | 剛性の部分を有するピリド［４，３−ｂ］インドール |
| JP5551708B2 (ja) | 2008-10-31 | 2014-07-16 | メディベイション テクノロジーズ， インコーポレイテッド | アゼピノ［４，５−ｂ］インドール化合物およびその使用方法 |
| WO2010051561A1 (en) * | 2008-11-03 | 2010-05-06 | Chemocentryx, Inc. | Compounds for the treatment of osteoporosis and cancers |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| AU2010203356B2 (en) | 2009-01-09 | 2015-11-26 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US8063032B2 (en) | 2009-02-11 | 2011-11-22 | Sunovion Pharmaceuticals Inc. | Histamine H3 inverse agonists and antagonists and methods of use thereof |
| BRPI1006602A2 (pt) | 2009-04-29 | 2019-01-15 | Medivation Technologies Inc | composto, método para modular um receptor de histamina em um indivíduo, composição farmacêutica, kit e método para tratar um distúrbio cognitivo ou um distúrbio induzido por pelo menos um sintoma associado com a alteração da cognição |
| AU2010282990B2 (en) | 2009-04-29 | 2015-11-05 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
| MX2012002827A (es) * | 2009-09-11 | 2012-04-10 | Sunovion Pharmaceuticals Inc | Agonistas inversos y antagonistas de histamina h3 y metodos para usar los mismos. |
| WO2011038164A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
| JP5779183B2 (ja) | 2009-09-23 | 2015-09-16 | メディベイション テクノロジーズ， インコーポレイテッド | ピリド［４，３−ｂ］インドールおよび使用方法 |
| CN102724875B (zh) | 2009-09-23 | 2015-05-27 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚化合物及其使用方法 |
| US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
| WO2011103460A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]ondole derivatives and methods of use |
| US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
| DK2590647T3 (en) * | 2010-07-07 | 2018-02-12 | Univ Texas | Pro-neurogenic compounds |
| US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
| WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
| AU2012254158B2 (en) * | 2011-02-18 | 2016-02-04 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| WO2012112965A1 (en) * | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods of treating diabetes |
| EP2887805A4 (en) * | 2012-08-22 | 2016-08-17 | Medivation Technologies Inc | COMPOUNDS AND METHOD FOR TREATING BLOOD HIGH PRESSURE |
| AU2013305591B2 (en) | 2012-08-24 | 2017-04-13 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| EP2746258A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| EP2746257A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
| WO2015070234A2 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| CN105037298B (zh) * | 2015-07-08 | 2017-09-26 | 华南理工大学 | 一种含三氟甲基取代连续季碳中心环氧丙烷衍生物及合成方法 |
| BR112021016620A2 (pt) | 2019-02-27 | 2021-11-03 | Univ California | Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais |
| CN110526935A (zh) * | 2019-09-04 | 2019-12-03 | 天津理工大学 | 一种双硼氮杂菲及其衍生物的合成方法 |
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-
2009
- 2009-10-30 JP JP2011534828A patent/JP5551708B2/ja not_active Expired - Fee Related
- 2009-10-30 CN CN200980153432.3A patent/CN102316732B/zh not_active Expired - Fee Related
- 2009-10-30 US US12/610,152 patent/US8569287B2/en not_active Expired - Fee Related
- 2009-10-30 TW TW098137049A patent/TWI482773B/zh not_active IP Right Cessation
- 2009-10-30 AU AU2009308708A patent/AU2009308708B2/en not_active Ceased
- 2009-10-30 BR BRPI0921798A patent/BRPI0921798A2/pt not_active IP Right Cessation
- 2009-10-30 CA CA2742322A patent/CA2742322A1/en not_active Abandoned
- 2009-10-30 AR ARP090104221A patent/AR073924A1/es unknown
- 2009-10-30 WO PCT/US2009/062872 patent/WO2010051503A1/en active Application Filing
- 2009-10-30 EP EP09824200A patent/EP2348847A4/en not_active Withdrawn
-
2012
- 2012-05-29 HK HK12105246.7A patent/HK1164641A1/xx not_active IP Right Cessation
-
2013
- 2013-03-08 US US13/791,867 patent/US20130190295A1/en not_active Abandoned
- 2013-03-08 US US13/791,648 patent/US9409910B2/en not_active Expired - Fee Related
- 2013-10-08 US US14/048,656 patent/US9481676B2/en not_active Expired - Fee Related
Also Published As
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|---|---|
| TW201022270A (en) | 2010-06-16 |
| US20140213577A1 (en) | 2014-07-31 |
| EP2348847A1 (en) | 2011-08-03 |
| JP2012507567A (ja) | 2012-03-29 |
| US8569287B2 (en) | 2013-10-29 |
| AR073924A1 (es) | 2010-12-09 |
| US20130190295A1 (en) | 2013-07-25 |
| AU2009308708B2 (en) | 2015-11-19 |
| EP2348847A4 (en) | 2012-05-23 |
| HK1164641A1 (en) | 2012-09-28 |
| JP5551708B2 (ja) | 2014-07-16 |
| US20140088087A1 (en) | 2014-03-27 |
| AU2009308708A1 (en) | 2010-05-06 |
| US9481676B2 (en) | 2016-11-01 |
| CA2742322A1 (en) | 2010-05-06 |
| US20100152163A1 (en) | 2010-06-17 |
| WO2010051503A1 (en) | 2010-05-06 |
| CN102316732A (zh) | 2012-01-11 |
| CN102316732B (zh) | 2015-04-01 |
| TWI482773B (zh) | 2015-05-01 |
| US9409910B2 (en) | 2016-08-09 |
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