MX2011011130A - Proteina o peptido de fusion con vida media in vivo incrementada mantenido por liberacion in vivo sostenida, y metodo para incrementar la vida media in vivo usando el mismo. - Google Patents
Proteina o peptido de fusion con vida media in vivo incrementada mantenido por liberacion in vivo sostenida, y metodo para incrementar la vida media in vivo usando el mismo.Info
- Publication number
- MX2011011130A MX2011011130A MX2011011130A MX2011011130A MX2011011130A MX 2011011130 A MX2011011130 A MX 2011011130A MX 2011011130 A MX2011011130 A MX 2011011130A MX 2011011130 A MX2011011130 A MX 2011011130A MX 2011011130 A MX2011011130 A MX 2011011130A
- Authority
- MX
- Mexico
- Prior art keywords
- vivo
- life
- peptide
- vivo half
- fusion protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a una proteína o péptido de fusión, cuya vida media in vivo se incrementa porque mantiene liberación sostenida in vivo, y a un método para incrementar la vida media in vivo usando el mismo; una proteína o péptido de fusión de conformidad con la presente invención, tiene excelente estabilidad in vivo por la unión de una proteína fisiológicamente activa o un péptido fisiológicamente activo a una antitripsina alfa-1 o mutante de antitripsina alfa-1 con uno o más aminoácidos mutados que mantiene liberación sostenida in vivo e incrementa significativamente la vida media del mismo en la sangre (T1/2), en comparación con una proteína fisiológicamente activa o un péptido fisiológicamente activo inherente; de esta manera, una proteína o péptido de fusión de conformidad con la presente invención puede ser útil en el desarrollo de una preparación de liberación sostenida de un fármaco de proteínas o péptidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20090035190 | 2009-04-22 | ||
| PCT/KR2010/002520 WO2010123290A2 (ko) | 2009-04-22 | 2010-04-22 | 체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011011130A true MX2011011130A (es) | 2011-11-18 |
Family
ID=43011621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011011130A MX2011011130A (es) | 2009-04-22 | 2010-04-22 | Proteina o peptido de fusion con vida media in vivo incrementada mantenido por liberacion in vivo sostenida, y metodo para incrementar la vida media in vivo usando el mismo. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9012606B2 (es) |
| EP (1) | EP2423233B1 (es) |
| JP (1) | JP5727459B2 (es) |
| KR (1) | KR101183262B1 (es) |
| CN (1) | CN102439044B (es) |
| AU (1) | AU2010239861B2 (es) |
| BR (1) | BRPI1006443B1 (es) |
| CA (1) | CA2758445C (es) |
| MX (1) | MX2011011130A (es) |
| RU (1) | RU2503688C2 (es) |
| WO (1) | WO2010123290A2 (es) |
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| JP6216921B2 (ja) | 2011-06-24 | 2017-11-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１抗トリプシン融合分子のための組成物、方法および使用 |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| WO2013003641A2 (en) | 2011-06-28 | 2013-01-03 | Inhibrx Llc | Serpin fusion polypeptides and methods of use thereof |
| KR101402702B1 (ko) * | 2011-09-15 | 2014-06-05 | (주)알테오젠 | 신규한 알파-1 안티트립신 변이체, 이의 제조방법 및 용도 |
| US10478508B2 (en) | 2012-01-10 | 2019-11-19 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
| US9289507B2 (en) | 2012-05-17 | 2016-03-22 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
| WO2013183948A1 (ko) * | 2012-06-05 | 2013-12-12 | 씨제이제일제당 (주) | 고당화된 지속형 인간 성장호르몬 단백질 및 이의 제조방법 |
| KR101460266B1 (ko) * | 2012-06-05 | 2014-11-11 | 씨제이헬스케어 주식회사 | 신규한 지속형 인간 성장호르몬의 정제 방법 |
| KR101504824B1 (ko) * | 2013-05-31 | 2015-03-23 | 씨제이헬스케어 주식회사 | 고당화된 지속형 인간 성장호르몬 단백질 및 이의 제조방법 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
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| BR112015014510A2 (pt) | 2012-12-21 | 2017-11-21 | Sanofi Sa | agonistas de glp1/gip duais ou de glp1/gip/glucagon trigonais |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| EP3220961B1 (en) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| WO2016102580A1 (en) * | 2014-12-22 | 2016-06-30 | Novo Nordisk A/S | Alpha-1-antitrypsin (a1at) fusion proteins and uses thereof |
| CN111388680B (zh) * | 2015-01-28 | 2024-01-05 | 中国科学院天津工业生物技术研究所 | 一种多肽复合物作为多肽或蛋白质药物载体的应用、方法及其融合蛋白复合物 |
| US10993993B2 (en) * | 2015-05-28 | 2021-05-04 | Immunoforge Co., Ltd. | Pharmaceutical composition for treating muscle atrophy or sarcopenia including glucagon-like peptide (GLP-1) or GLP-1 receptor agonist |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2017003270A1 (ko) * | 2015-07-02 | 2017-01-05 | 주식회사 녹십자 | 헌터증후군 치료제 및 치료방법 |
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| PT3348635T (pt) * | 2015-09-08 | 2021-03-15 | Japan Chem Res | Novo mutante de albumina do soro humano |
| WO2018071528A1 (en) * | 2016-10-11 | 2018-04-19 | University Of Georgia Research Foundation, Inc. | Proteins and method for treating obesity and associated comorbidities |
| US11492390B2 (en) * | 2017-04-02 | 2022-11-08 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Mutant alpha-1-antitrypsin compositions and use thereof |
| KR101964376B1 (ko) | 2017-09-29 | 2019-04-01 | 주식회사 나이벡 | 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료 |
| KR102167827B1 (ko) * | 2017-12-20 | 2020-10-20 | 주식회사 알테오젠 | 신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질 |
| CN107916257B (zh) * | 2018-01-09 | 2020-07-28 | 华南理工大学 | T1脂肪酶突变体和应用 |
| WO2019222435A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
| WO2019237079A2 (en) * | 2018-06-07 | 2019-12-12 | Xiaolong Zhang | Pharmaceutical composition containing fusion protein and use thereof |
| WO2020050626A1 (ko) * | 2018-09-05 | 2020-03-12 | 주식회사 엘지화학 | O-글리코실화 가능한 폴리펩타이드 영역을 포함하는 융합 폴리펩타이드 |
| CN114573715A (zh) * | 2022-03-14 | 2022-06-03 | 江苏雅酶医药科技有限公司 | 一种重组长效人透明质酸酶及其生产方法和应用 |
| CN117186237A (zh) * | 2022-05-29 | 2023-12-08 | 中国医学科学院药物研究所 | 一种含有糜蛋白酶抑制肽的胰岛素杂交肽及其应用 |
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| CN103212084B (zh) * | 2003-11-13 | 2018-07-13 | 韩美科学株式会社 | 含有免疫球蛋白fc区作为载体的药物组合物 |
| US8921528B2 (en) | 2004-06-01 | 2014-12-30 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
| CA2658673A1 (en) | 2005-07-27 | 2008-02-01 | Gerald J. Prud'homme | Composition and method for prevention and treatment of type i and type ii diabetes |
-
2010
- 2010-04-22 BR BRPI1006443-5A patent/BRPI1006443B1/pt active IP Right Grant
- 2010-04-22 KR KR1020100037496A patent/KR101183262B1/ko active IP Right Grant
- 2010-04-22 US US13/265,775 patent/US9012606B2/en active Active
- 2010-04-22 RU RU2011147216/10A patent/RU2503688C2/ru active
- 2010-04-22 JP JP2012505833A patent/JP5727459B2/ja active Active
- 2010-04-22 AU AU2010239861A patent/AU2010239861B2/en active Active
- 2010-04-22 CA CA2758445A patent/CA2758445C/en active Active
- 2010-04-22 MX MX2011011130A patent/MX2011011130A/es active IP Right Grant
- 2010-04-22 WO PCT/KR2010/002520 patent/WO2010123290A2/ko active Application Filing
- 2010-04-22 CN CN201080017980.6A patent/CN102439044B/zh active Active
- 2010-04-22 EP EP10767304.8A patent/EP2423233B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011147216A (ru) | 2013-05-27 |
| RU2503688C2 (ru) | 2014-01-10 |
| JP5727459B2 (ja) | 2015-06-03 |
| US9012606B2 (en) | 2015-04-21 |
| EP2423233A4 (en) | 2012-09-26 |
| KR101183262B1 (ko) | 2012-09-14 |
| CN102439044A (zh) | 2012-05-02 |
| CA2758445A1 (en) | 2010-10-28 |
| KR20100116558A (ko) | 2010-11-01 |
| JP2012524062A (ja) | 2012-10-11 |
| BRPI1006443B1 (pt) | 2021-05-25 |
| US20120094356A1 (en) | 2012-04-19 |
| AU2010239861A1 (en) | 2011-10-27 |
| EP2423233B1 (en) | 2015-03-11 |
| BRPI1006443A2 (pt) | 2016-09-27 |
| CN102439044B (zh) | 2014-08-13 |
| WO2010123290A2 (ko) | 2010-10-28 |
| CA2758445C (en) | 2016-02-16 |
| AU2010239861B2 (en) | 2013-07-11 |
| EP2423233A2 (en) | 2012-02-29 |
| WO2010123290A3 (ko) | 2011-03-03 |
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| FG | Grant or registration |