MX2010004929A - Derivados de 4-bencil-amino-1-carboxi-acil-piperidina como inhibidores de proteina de transferencia de colesterol-ester (cetp) utiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis. - Google Patents

Derivados de 4-bencil-amino-1-carboxi-acil-piperidina como inhibidores de proteina de transferencia de colesterol-ester (cetp) utiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis.

Info

Publication number
MX2010004929A
MX2010004929A MX2010004929A MX2010004929A MX2010004929A MX 2010004929 A MX2010004929 A MX 2010004929A MX 2010004929 A MX2010004929 A MX 2010004929A MX 2010004929 A MX2010004929 A MX 2010004929A MX 2010004929 A MX2010004929 A MX 2010004929A
Authority
MX
Mexico
Prior art keywords
cetp
treatment
compound
dhool
tea leaves
Prior art date
Application number
MX2010004929A
Other languages
English (en)
Inventor
Ichiro Umemura
Yuki Iwaki
Muneto Mogi
Ken Yamada
Hidetomo Imase
Toshio Kawanami
Hongbo Qin
Kayo Yasoshima
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40343337&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010004929(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2010004929A publication Critical patent/MX2010004929A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona un compuesto de la fórmula (i): (ver fórmula (I)) en donde las variantes Rl, R2, R3, R4, R5, R6, R7 son como se definen en la presente, y en donde el compuesto mencionado es un inhibidor de la proteína de transferencia de colesteril-éster, y por consiguiente, se pueden emplear para el tratamiento de un trastorno o una enfermedad mediada por la proteína de transferencia de colesteril-éster, o que responda a la inhibición de la proteína de transferencia de colesteril-éster.
MX2010004929A 2007-11-05 2008-11-03 Derivados de 4-bencil-amino-1-carboxi-acil-piperidina como inhibidores de proteina de transferencia de colesterol-ester (cetp) utiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis. MX2010004929A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98545607P 2007-11-05 2007-11-05
PCT/EP2008/064859 WO2009059943A1 (en) 2007-11-05 2008-11-03 4-benzylamino-1-carboxyacyl-piperidine derivatives as cetp inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis

Publications (1)

Publication Number Publication Date
MX2010004929A true MX2010004929A (es) 2010-05-27

Family

ID=40343337

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004929A MX2010004929A (es) 2007-11-05 2008-11-03 Derivados de 4-bencil-amino-1-carboxi-acil-piperidina como inhibidores de proteina de transferencia de colesterol-ester (cetp) utiles para el tratamiento de enfermedades tales como hiperlipidemia o arteriosclerosis.

Country Status (25)

Country Link
US (3) US8193349B2 (es)
EP (2) EP2207775B1 (es)
JP (1) JP5555635B2 (es)
KR (1) KR101564793B1 (es)
CN (1) CN101910150B (es)
AR (1) AR069165A1 (es)
AT (1) ATE550333T1 (es)
AU (1) AU2008324243B2 (es)
BR (1) BRPI0819223A2 (es)
CA (1) CA2704633C (es)
CL (1) CL2008003284A1 (es)
CY (1) CY1112706T1 (es)
DK (1) DK2207775T3 (es)
EA (1) EA022912B1 (es)
ES (2) ES2381518T3 (es)
HK (1) HK1168096A1 (es)
HR (1) HRP20120476T1 (es)
JO (1) JO2732B1 (es)
MX (1) MX2010004929A (es)
PE (1) PE20090982A1 (es)
PL (2) PL2463282T3 (es)
PT (2) PT2207775E (es)
SI (1) SI2207775T1 (es)
TW (1) TWI426910B (es)
WO (1) WO2009059943A1 (es)

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Also Published As

Publication number Publication date
ES2381518T3 (es) 2012-05-29
US20090118287A1 (en) 2009-05-07
HK1168096A1 (en) 2012-12-21
PL2463282T3 (pl) 2014-01-31
TWI426910B (zh) 2014-02-21
EP2207775A1 (en) 2010-07-21
EP2463282A1 (en) 2012-06-13
PE20090982A1 (es) 2009-08-13
BRPI0819223A2 (pt) 2020-08-18
TW200924779A (en) 2009-06-16
AU2008324243A1 (en) 2009-05-14
KR101564793B1 (ko) 2015-10-30
ATE550333T1 (de) 2012-04-15
PT2463282E (pt) 2013-11-11
US20120208816A1 (en) 2012-08-16
US20120264773A1 (en) 2012-10-18
EP2207775B1 (en) 2012-03-21
DK2207775T3 (da) 2012-06-18
EA201000750A1 (ru) 2010-12-30
JO2732B1 (en) 2013-09-15
CN101910150B (zh) 2013-09-18
CY1112706T1 (el) 2016-02-10
PT2207775E (pt) 2012-05-11
US8440682B2 (en) 2013-05-14
PL2207775T3 (pl) 2012-08-31
SI2207775T1 (sl) 2012-05-31
AU2008324243B2 (en) 2012-03-08
CA2704633C (en) 2015-10-20
EA022912B1 (ru) 2016-03-31
WO2009059943A1 (en) 2009-05-14
EP2463282B1 (en) 2013-08-07
JP5555635B2 (ja) 2014-07-23
ES2434417T3 (es) 2013-12-16
CA2704633A1 (en) 2009-05-14
US8193349B2 (en) 2012-06-05
JP2011503026A (ja) 2011-01-27
CN101910150A (zh) 2010-12-08
KR20100094986A (ko) 2010-08-27
HRP20120476T1 (hr) 2012-06-30
US8420641B2 (en) 2013-04-16
AR069165A1 (es) 2010-01-06
CL2008003284A1 (es) 2009-05-15

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