MX342824B - Nuevos compuestos de triazol iii. - Google Patents
Nuevos compuestos de triazol iii.Info
- Publication number
- MX342824B MX342824B MX2013005965A MX2013005965A MX342824B MX 342824 B MX342824 B MX 342824B MX 2013005965 A MX2013005965 A MX 2013005965A MX 2013005965 A MX2013005965 A MX 2013005965A MX 342824 B MX342824 B MX 342824B
- Authority
- MX
- Mexico
- Prior art keywords
- triazole compounds
- compounds iii
- novel triazole
- present
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Abstract
La presente invención se refiere a nuevos compuestos de 1,2,3-triazol-imidazol de fórmula (I) en donde X, R1, R2, y R3 son como se describen en la presente, así como también sales y ésteres de los mismos farmacéuticamente aceptables. Los compuestos activos de la presente invención tienen afinidad y selectividad para el receptor GABA A a5. Además la presente invención está relacionada con la manufactura de los compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y su uso como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10194496 | 2010-12-10 | ||
PCT/EP2011/072041 WO2012076590A1 (en) | 2010-12-10 | 2011-12-07 | Novel triazole compounds iii |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013005965A MX2013005965A (es) | 2013-07-15 |
MX342824B true MX342824B (es) | 2016-10-12 |
Family
ID=45099109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013005965A MX342824B (es) | 2010-12-10 | 2011-12-07 | Nuevos compuestos de triazol iii. |
Country Status (10)
Country | Link |
---|---|
US (1) | US8466181B2 (es) |
EP (1) | EP2649064B1 (es) |
JP (1) | JP6138049B2 (es) |
KR (1) | KR20130130773A (es) |
CN (1) | CN103249728B (es) |
BR (1) | BR112013014362A2 (es) |
CA (1) | CA2819277A1 (es) |
HK (1) | HK1186177A1 (es) |
MX (1) | MX342824B (es) |
WO (1) | WO2012076590A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9168259B2 (en) * | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
KR20150033678A (ko) | 2012-06-26 | 2015-04-01 | 사니오나 에이피에스 | 페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도 |
CA2876780A1 (en) | 2012-06-26 | 2014-01-03 | Saniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
US9969724B2 (en) | 2014-04-16 | 2018-05-15 | Merck Sharp & Dohme Corp. | Factor IXa inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3824658A1 (de) * | 1988-07-15 | 1990-01-18 | Schering Ag | N-hetaryl-imidazolderivate |
IT1237793B (it) | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
CN1237055C (zh) * | 2000-05-19 | 2006-01-18 | 山之内制药株式会社 | ***衍生物 |
US6727364B2 (en) * | 2001-04-30 | 2004-04-27 | The Procter & Gamble Company | Triazole compounds useful in treating diseases associated with unwanted cytokine activity |
PL1725544T3 (pl) * | 2004-03-09 | 2009-10-30 | Boehringer Ingelheim Pharmaceuticals Inc | 3-[4-Heterocyklilo-1,2,3-triazol-1-ilo]-N-arylobenzamidy jako inhibitory wytwarzania cytokin, do leczenia przewlekłych chorób zapalnych |
AU2006331437B2 (en) * | 2005-12-27 | 2012-07-05 | F. Hoffmann-La Roche Ag | Aryl-Isoxazol-4-yl-Imidazole derivatives |
WO2009000662A1 (en) * | 2007-06-22 | 2008-12-31 | F. Hoffmann-La Roche Ag | Isoxazole-imidazole derivatives |
AU2008333320B2 (en) | 2007-12-04 | 2012-12-20 | F. Hoffmann-La Roche Ag | Isoxazolo-pyrazine derivatives |
-
2011
- 2011-12-02 US US13/309,589 patent/US8466181B2/en active Active
- 2011-12-07 KR KR1020137017921A patent/KR20130130773A/ko not_active Application Discontinuation
- 2011-12-07 CN CN201180058810.7A patent/CN103249728B/zh active Active
- 2011-12-07 MX MX2013005965A patent/MX342824B/es active IP Right Grant
- 2011-12-07 EP EP11791572.8A patent/EP2649064B1/en active Active
- 2011-12-07 WO PCT/EP2011/072041 patent/WO2012076590A1/en active Application Filing
- 2011-12-07 CA CA2819277A patent/CA2819277A1/en not_active Abandoned
- 2011-12-07 JP JP2013542524A patent/JP6138049B2/ja not_active Expired - Fee Related
- 2011-12-07 BR BR112013014362A patent/BR112013014362A2/pt active Search and Examination
-
2013
- 2013-12-06 HK HK13113606.4A patent/HK1186177A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MX2013005965A (es) | 2013-07-15 |
CN103249728B (zh) | 2015-01-21 |
JP2014502279A (ja) | 2014-01-30 |
EP2649064A1 (en) | 2013-10-16 |
EP2649064B1 (en) | 2019-10-02 |
CA2819277A1 (en) | 2012-06-14 |
US8466181B2 (en) | 2013-06-18 |
US20120149675A1 (en) | 2012-06-14 |
WO2012076590A1 (en) | 2012-06-14 |
RU2013130213A (ru) | 2015-01-20 |
HK1186177A1 (en) | 2014-03-07 |
CN103249728A (zh) | 2013-08-14 |
BR112013014362A2 (pt) | 2016-09-27 |
JP6138049B2 (ja) | 2017-05-31 |
KR20130130773A (ko) | 2013-12-02 |
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Legal Events
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FG | Grant or registration |