MX2010003849A - Antagonistas de cgrp. - Google Patents
Antagonistas de cgrp.Info
- Publication number
- MX2010003849A MX2010003849A MX2010003849A MX2010003849A MX2010003849A MX 2010003849 A MX2010003849 A MX 2010003849A MX 2010003849 A MX2010003849 A MX 2010003849A MX 2010003849 A MX2010003849 A MX 2010003849A MX 2010003849 A MX2010003849 A MX 2010003849A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- salts
- cgrp antagonists
- hydrates
- tautomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Son objeto de la presente invenci?n nuevos antagonistas de CGRP de la f?rmula general (I) (Ver f?rmula I) en la que U, V, X, Y, R1, R2 y R3 est?n definidos como se menciona en lo que sigue, sus taut?meros, sus is?meros, sus diastereois?meros, sus enanti?meros, sus hidratos, sus mezclas y sus sales, as? como los hidratos de las sales, en especial sus sales fisiol?gicamente compatibles con ?cidos o bases inorg?nicos u org?nicos, medicamentos que contienen a estos compuestos, su uso y procedimientos para su preparaci?n.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07118811 | 2007-10-18 | ||
PCT/EP2008/063967 WO2009050234A1 (de) | 2007-10-18 | 2008-10-16 | Cgrp-antagonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010003849A true MX2010003849A (es) | 2010-04-27 |
Family
ID=39047647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010003849A MX2010003849A (es) | 2007-10-18 | 2008-10-16 | Antagonistas de cgrp. |
Country Status (17)
Country | Link |
---|---|
US (1) | US8450327B2 (es) |
EP (2) | EP2205599B1 (es) |
JP (1) | JP5366960B2 (es) |
KR (1) | KR20100091972A (es) |
CN (1) | CN101827845A (es) |
AU (1) | AU2008313733A1 (es) |
BR (1) | BRPI0817835A2 (es) |
CA (1) | CA2702503A1 (es) |
CO (1) | CO6270226A2 (es) |
EA (1) | EA201000612A1 (es) |
EC (1) | ECSP10010105A (es) |
IL (1) | IL204928A0 (es) |
MA (1) | MA31782B1 (es) |
MX (1) | MX2010003849A (es) |
NZ (1) | NZ585347A (es) |
TN (1) | TN2010000173A1 (es) |
WO (1) | WO2009050234A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100091972A (ko) | 2007-10-18 | 2010-08-19 | 베링거 인겔하임 인터내셔날 게엠베하 | Cgrp 길항제 |
EP2065381A1 (de) * | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
EP2251338A3 (de) * | 2007-11-22 | 2011-06-08 | Boehringer Ingelheim International GmbH | Organische Verbindungen |
US8653269B2 (en) | 2010-03-12 | 2014-02-18 | Nippon Soda Co., Ltd. | Process for preparation of t-butoxycarbonylamine compounds |
WO2015119848A1 (en) | 2014-02-05 | 2015-08-13 | Merck Sharp & Dohme Corp. | Tablet formulation for cgrp-active compounds |
EP3464272B1 (en) | 2016-06-07 | 2021-12-08 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
AU2018239542C1 (en) | 2017-03-23 | 2021-02-11 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as SHP2 inhibitors |
GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
CA3206184A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ20003672A3 (cs) | 1998-04-10 | 2001-08-15 | G. D. Searle & Co. | Heterocyklické glycyl-beta-alaninové deriváty jako agonisté vitronektinu |
DE19911039A1 (de) | 1999-03-12 | 2000-09-14 | Boehringer Ingelheim Pharma | Abgewandelte Aminosäureamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
GB2355456A (en) | 1999-09-30 | 2001-04-25 | Merck & Co Inc | Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists |
DE19952147A1 (de) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
EP1322628A2 (en) | 2000-09-14 | 2003-07-02 | Schering Corporation | Substituted urea neuropeptide y y5 receptor antagonists |
US6831087B2 (en) | 2001-11-09 | 2004-12-14 | Hoffmann-La Roche Inc. | Pyridine substituted isoquinoline derivatives |
KR20120004541A (ko) | 2002-06-05 | 2012-01-12 | 브리스톨-마이어스 스큅 컴퍼니 | 칼시토닌 유전자 관련 펩티드 수용체 길항제 |
DE10250080A1 (de) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
DE10250082A1 (de) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
JP2007513058A (ja) | 2003-09-08 | 2007-05-24 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
DE102004018795A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
DE102004018794A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
DE102004019492A1 (de) | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7659300B2 (en) | 2004-09-08 | 2010-02-09 | Merck Sharp & Dohme Corp. | Monocyclic anilide spirolactam CGRP receptor antagonists |
WO2006031513A2 (en) * | 2004-09-09 | 2006-03-23 | Merck & Co., Inc. | Aryl spirolactam cgrp receptor antagonists |
EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
JP5426878B2 (ja) | 2005-05-24 | 2014-02-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atp−結合カセットトランスポーターのモジュレーター |
MX2007015705A (es) | 2005-06-29 | 2008-02-15 | Palau Pharma Sa | Derivados biciclicos como inhibidores de la cinasa p38. |
DE102005050892A1 (de) | 2005-10-21 | 2007-04-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
GEP20115140B (en) | 2006-05-09 | 2011-01-10 | Merck Sharp And Dome Corp | Substituted spirocyclic cgrp receptor antagonists |
WO2008070014A2 (en) | 2006-12-04 | 2008-06-12 | Neurogen Corporation | Biaryl ketone-substituted piperidines |
WO2009034029A2 (de) | 2007-09-07 | 2009-03-19 | Boehringer Ingelheim International Gmbh | 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten |
EP2065381A1 (de) * | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
KR20100091972A (ko) | 2007-10-18 | 2010-08-19 | 베링거 인겔하임 인터내셔날 게엠베하 | Cgrp 길항제 |
EP2062889A1 (de) * | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
JP2011504481A (ja) * | 2007-11-22 | 2011-02-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物 |
EP2251338A3 (de) * | 2007-11-22 | 2011-06-08 | Boehringer Ingelheim International GmbH | Organische Verbindungen |
-
2008
- 2008-10-16 KR KR1020107010480A patent/KR20100091972A/ko not_active Application Discontinuation
- 2008-10-16 CN CN200880112297A patent/CN101827845A/zh active Pending
- 2008-10-16 US US12/682,853 patent/US8450327B2/en active Active
- 2008-10-16 MX MX2010003849A patent/MX2010003849A/es active IP Right Grant
- 2008-10-16 EP EP08839172A patent/EP2205599B1/de active Active
- 2008-10-16 JP JP2010529384A patent/JP5366960B2/ja active Active
- 2008-10-16 WO PCT/EP2008/063967 patent/WO2009050234A1/de active Application Filing
- 2008-10-16 BR BRPI0817835 patent/BRPI0817835A2/pt not_active IP Right Cessation
- 2008-10-16 EA EA201000612A patent/EA201000612A1/ru unknown
- 2008-10-16 AU AU2008313733A patent/AU2008313733A1/en not_active Abandoned
- 2008-10-16 EP EP11176974.1A patent/EP2386558B1/de active Active
- 2008-10-16 NZ NZ585347A patent/NZ585347A/en not_active IP Right Cessation
- 2008-10-16 CA CA2702503A patent/CA2702503A1/en not_active Abandoned
-
2010
- 2010-04-08 IL IL204928A patent/IL204928A0/en unknown
- 2010-04-14 EC EC2010010105A patent/ECSP10010105A/es unknown
- 2010-04-16 CO CO10044754A patent/CO6270226A2/es not_active Application Discontinuation
- 2010-04-16 TN TN2010000173A patent/TN2010000173A1/fr unknown
- 2010-04-20 MA MA32781A patent/MA31782B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP2386558B1 (de) | 2014-10-01 |
EP2205599A1 (de) | 2010-07-14 |
ECSP10010105A (es) | 2010-06-29 |
US20110172218A1 (en) | 2011-07-14 |
JP5366960B2 (ja) | 2013-12-11 |
IL204928A0 (en) | 2010-11-30 |
BRPI0817835A2 (pt) | 2015-03-31 |
KR20100091972A (ko) | 2010-08-19 |
CN101827845A (zh) | 2010-09-08 |
MA31782B1 (fr) | 2010-10-01 |
CA2702503A1 (en) | 2009-04-23 |
WO2009050234A1 (de) | 2009-04-23 |
CO6270226A2 (es) | 2011-04-20 |
NZ585347A (en) | 2011-09-30 |
EP2205599B1 (de) | 2012-06-06 |
US8450327B2 (en) | 2013-05-28 |
EA201000612A1 (ru) | 2010-10-29 |
AU2008313733A1 (en) | 2009-04-23 |
EP2386558A1 (de) | 2011-11-16 |
JP2011500637A (ja) | 2011-01-06 |
TN2010000173A1 (fr) | 2011-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FG | Grant or registration |