MX2009008527A - Compuestos de amonio cuaternario y difenilmetilo utiles como antagonistas del receptor muscarinico. - Google Patents

Compuestos de amonio cuaternario y difenilmetilo utiles como antagonistas del receptor muscarinico.

Info

Publication number
MX2009008527A
MX2009008527A MX2009008527A MX2009008527A MX2009008527A MX 2009008527 A MX2009008527 A MX 2009008527A MX 2009008527 A MX2009008527 A MX 2009008527A MX 2009008527 A MX2009008527 A MX 2009008527A MX 2009008527 A MX2009008527 A MX 2009008527A
Authority
MX
Mexico
Prior art keywords
compounds
receptor antagonists
muscarinic receptor
quaternary ammonium
compounds useful
Prior art date
Application number
MX2009008527A
Other languages
English (en)
Inventor
Yu-Hua Ji
Craig Husfeld
Yongqi Mu
Christopher Lange
Rick Lee
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39522128&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009008527(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MX2009008527A publication Critical patent/MX2009008527A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms

Abstract

La presente invención proporciona los compuestos de la fórmula (I) en una forma de una sal o en una forma switteriónica, o una sal de los mismos farmacéuticamente aceptable, en donde R1-6, a-e y Q son como se definen en la especificación. Estos compuestos son antagonistas del receptor muscarínico. La invención también proporciona composiciones farmacéuticas que contienen tales compuestos, procesos para la preparación de tales compuestos y métodos de uso de tales compuestos, por ejemplo, para tratar trastornos pulmonares tales como la enfermedad pulmonar obstructiva crónica y el asma. (ver fórmula I).
MX2009008527A 2007-02-23 2008-02-21 Compuestos de amonio cuaternario y difenilmetilo utiles como antagonistas del receptor muscarinico. MX2009008527A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90311007P 2007-02-23 2007-02-23
PCT/US2008/002321 WO2008103426A1 (en) 2007-02-23 2008-02-21 Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
MX2009008527A true MX2009008527A (es) 2009-08-27

Family

ID=39522128

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008527A MX2009008527A (es) 2007-02-23 2008-02-21 Compuestos de amonio cuaternario y difenilmetilo utiles como antagonistas del receptor muscarinico.

Country Status (13)

Country Link
US (4) US7834185B2 (es)
EP (1) EP2121594B1 (es)
JP (2) JP5528817B2 (es)
KR (1) KR101495708B1 (es)
CN (1) CN101616893B (es)
AU (1) AU2008218962B2 (es)
BR (1) BRPI0807615A8 (es)
CA (1) CA2675942C (es)
ES (1) ES2554646T3 (es)
IL (1) IL199922A (es)
MX (1) MX2009008527A (es)
RU (1) RU2452728C2 (es)
WO (1) WO2008103426A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2675942C (en) 2007-02-23 2016-04-12 Theravance, Inc. Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
CN101663270B (zh) 2007-04-24 2013-07-17 施万制药 可用作蕈毒碱受体拮抗剂的季铵化合物
PL2197841T3 (pl) 2007-09-07 2012-04-30 Theravance Inc Związki zawierające guanidynę przydatne jako antagoniści receptorów
EP2222637A1 (en) 2007-12-14 2010-09-01 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
GB2468073B (en) * 2008-02-26 2012-09-05 Elevation Pharmaceuticals Inc Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
US20100055045A1 (en) 2008-02-26 2010-03-04 William Gerhart Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
US20150150802A1 (en) 2012-07-05 2015-06-04 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscarinic antagonists
US11065235B2 (en) 2017-05-19 2021-07-20 Council Of Scientific & Industrial Research Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof
JP2023523300A (ja) 2020-04-30 2023-06-02 イドーシア ファーマシューティカルズ リミテッド Ｃｃｒ６受容体調節剤としてのアゼチジン－３－イルメタノール誘導体
WO2023057548A1 (en) 2021-10-07 2023-04-13 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators
TW202325278A (zh) 2021-10-26 2023-07-01 瑞士商愛杜西亞製藥有限公司 Ccr6受體調節劑
AR127486A1 (es) 2021-10-28 2024-01-31 Idorsia Pharmaceuticals Ltd Moduladores del receptor ccr6

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US5070087A (en) * 1989-05-08 1991-12-03 A. H. Robins Company, Incorporated Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents
GB8928042D0 (en) * 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
WO2001042212A1 (en) 1999-12-07 2001-06-14 Theravance, Inc. Carbamate derivatives having muscarinic receptor antagonist activity
WO2002004402A1 (fr) * 2000-07-11 2002-01-17 Banyu Pharmaceutical Co., Ltd. Derives d'ester
WO2003035599A1 (en) * 2001-10-26 2003-05-01 Pharmacia & Upjohn Company Quarternary ammonium compounds and their use as antimuscarinic agents
GB0207104D0 (en) * 2002-03-26 2002-05-08 Pfizer Ltd Stable hydrate of a muscarinic receptor antagonist
ES2206021B1 (es) * 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
TW200412945A (en) * 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
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CA2675942C (en) 2007-02-23 2016-04-12 Theravance, Inc. Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
CN101663270B (zh) * 2007-04-24 2013-07-17 施万制药 可用作蕈毒碱受体拮抗剂的季铵化合物
PL2197841T3 (pl) 2007-09-07 2012-04-30 Theravance Inc Związki zawierające guanidynę przydatne jako antagoniści receptorów
EP2222637A1 (en) 2007-12-14 2010-09-01 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists

Also Published As

Publication number Publication date
US8802856B2 (en) 2014-08-12
US7834185B2 (en) 2010-11-16
AU2008218962B2 (en) 2013-03-14
WO2008103426A1 (en) 2008-08-28
JP5528817B2 (ja) 2014-06-25
US20110021787A1 (en) 2011-01-27
US20080207736A1 (en) 2008-08-28
US20140051864A1 (en) 2014-02-20
IL199922A0 (en) 2010-04-15
US8592453B2 (en) 2013-11-26
BRPI0807615A2 (pt) 2017-10-31
RU2452728C2 (ru) 2012-06-10
CA2675942C (en) 2016-04-12
EP2121594A1 (en) 2009-11-25
CN101616893A (zh) 2009-12-30
CN101616893B (zh) 2014-01-29
EP2121594B1 (en) 2015-10-21
US20110020231A1 (en) 2011-01-27
BRPI0807615A8 (pt) 2017-12-05
KR20090117948A (ko) 2009-11-16
US8378121B2 (en) 2013-02-19
IL199922A (en) 2014-08-31
ES2554646T3 (es) 2015-12-22
JP2010519299A (ja) 2010-06-03
RU2009135389A (ru) 2011-03-27
KR101495708B1 (ko) 2015-02-25
CA2675942A1 (en) 2008-02-28
JP2014098031A (ja) 2014-05-29
AU2008218962A1 (en) 2008-08-28

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