BRPI0807615A2 - compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico - Google Patents
compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínicoInfo
- Publication number
- BRPI0807615A2 BRPI0807615A2 BRPI0807615A BRPI0807615A BRPI0807615A2 BR PI0807615 A2 BRPI0807615 A2 BR PI0807615A2 BR PI0807615 A BRPI0807615 A BR PI0807615A BR PI0807615 A BRPI0807615 A BR PI0807615A BR PI0807615 A2 BRPI0807615 A2 BR PI0807615A2
- Authority
- BR
- Brazil
- Prior art keywords
- quaternary ammonium
- receptor antagonists
- compounds useful
- muscarinic receptor
- diphenylmethyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90311007P | 2007-02-23 | 2007-02-23 | |
| PCT/US2008/002321 WO2008103426A1 (en) | 2007-02-23 | 2008-02-21 | Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0807615A2 true BRPI0807615A2 (pt) | 2017-10-31 |
| BRPI0807615A8 BRPI0807615A8 (pt) | 2017-12-05 |
Family
ID=39522128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0807615A BRPI0807615A8 (pt) | 2007-02-23 | 2008-02-21 | Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7834185B2 (pt) |
| EP (1) | EP2121594B1 (pt) |
| JP (2) | JP5528817B2 (pt) |
| KR (1) | KR101495708B1 (pt) |
| CN (1) | CN101616893B (pt) |
| AU (1) | AU2008218962B2 (pt) |
| BR (1) | BRPI0807615A8 (pt) |
| CA (1) | CA2675942C (pt) |
| ES (1) | ES2554646T3 (pt) |
| IL (1) | IL199922A (pt) |
| MX (1) | MX2009008527A (pt) |
| RU (1) | RU2452728C2 (pt) |
| WO (1) | WO2008103426A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0807615A8 (pt) | 2007-02-23 | 2017-12-05 | Theravance Inc | Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico |
| WO2008133900A1 (en) | 2007-04-24 | 2008-11-06 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| MX2010002576A (es) | 2007-09-07 | 2010-04-01 | Theravance Inc | Compuestos que contienen guanidina, utiles como antagonistas de los receptores muscarinicos. |
| WO2009079392A1 (en) | 2007-12-14 | 2009-06-25 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
| CA2716936C (en) * | 2008-02-26 | 2018-06-05 | Elevation Pharmaceuticals, Inc. | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| US20100055045A1 (en) | 2008-02-26 | 2010-03-04 | William Gerhart | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| GEP201706672B (en) | 2012-07-05 | 2017-05-25 | Arven Ilac Sanayi Ve Ticaret As | Dry powder inhaler compositions comprising long acting muscorinic antagonists |
| EP3625232B1 (en) | 2017-05-19 | 2021-06-23 | Council of Scientific and Industrial Research | Substituted methanopyrido [2, 1-a]isoindolones as machr modulators for treating various associated pathophysiological conditions and process for preparation thereof |
| TW202200560A (zh) | 2020-04-30 | 2022-01-01 | 瑞士商愛杜西亞製藥有限公司 | Ccr6受體調節劑 |
| WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
| CA3235910A1 (en) | 2021-10-26 | 2023-05-04 | Oliver Allemann | Ccr6 receptor modulators |
| AR127486A1 (es) | 2021-10-28 | 2024-01-31 | Idorsia Pharmaceuticals Ltd | Moduladores del receptor ccr6 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US903110A (en) | 1908-05-23 | 1908-11-03 | Us Electric Signal Company | Track-switch. |
| US4002766A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | Antiarrhythmia methods |
| GB8906166D0 (en) * | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| US5070087A (en) * | 1989-05-08 | 1991-12-03 | A. H. Robins Company, Incorporated | Aryl(alkyland alkylene)-N-((phenoxy and phenylthio)alkyl) aminoheterocyclics as cardiovascular, anthihistaminic, antisecretory and antiallergy agents |
| GB8928042D0 (en) * | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
| MXPA02005596A (es) | 1999-12-07 | 2004-09-10 | Theravance Inc | Derivados de carbamato con actividad antagonista para el rerceptor muscarinico. |
| WO2002004402A1 (fr) * | 2000-07-11 | 2002-01-17 | Banyu Pharmaceutical Co., Ltd. | Derives d'ester |
| US6890920B2 (en) * | 2001-10-26 | 2005-05-10 | Pharmacia & Upjohn Company | Quaternary ammonium compounds |
| GB0207104D0 (en) * | 2002-03-26 | 2002-05-08 | Pfizer Ltd | Stable hydrate of a muscarinic receptor antagonist |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| TW200412945A (en) | 2002-10-25 | 2004-08-01 | Upjohn Co | Quaternary ammonium compounds |
| TW200800953A (en) * | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| EP1615881A2 (en) * | 2003-04-01 | 2006-01-18 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2004091597A2 (en) * | 2003-04-15 | 2004-10-28 | Pharmacia & Upjohn Company Llc | Method of treating irritable bowel syndrome (ibs) |
| TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| PE20050231A1 (es) * | 2003-06-24 | 2005-05-20 | Novartis Ag | Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3 |
| PE20050861A1 (es) * | 2003-12-03 | 2005-12-10 | Glaxo Group Ltd | Derivados de sales ciclicas de amonio cuaternario como antagonistas del receptor muscarinico de acetilcolina |
| EP1723142A1 (en) * | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Diphenylmethyl compounds useful as muscarinic receptor antagonists |
| US7579345B2 (en) * | 2004-05-28 | 2009-08-25 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| JP2008525357A (ja) * | 2004-12-23 | 2008-07-17 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 抗ムスカリン活性を有するアゾール誘導体 |
| GB0428418D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| GB0428416D0 (en) | 2004-12-24 | 2005-02-02 | Novartis Ag | Organic compounds |
| WO2007018508A1 (en) * | 2005-07-28 | 2007-02-15 | Glaxo Group Limited | Novel m3 muscarinic acetycholine receptor antagonists |
| EP1937068A4 (en) * | 2005-08-18 | 2010-08-04 | Glaxo Group Ltd | ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS |
| BRPI0807615A8 (pt) | 2007-02-23 | 2017-12-05 | Theravance Inc | Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico |
| WO2008133900A1 (en) | 2007-04-24 | 2008-11-06 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| MX2010002576A (es) | 2007-09-07 | 2010-04-01 | Theravance Inc | Compuestos que contienen guanidina, utiles como antagonistas de los receptores muscarinicos. |
| WO2009079392A1 (en) | 2007-12-14 | 2009-06-25 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
-
2008
- 2008-02-21 BR BRPI0807615A patent/BRPI0807615A8/pt not_active Application Discontinuation
- 2008-02-21 CN CN200880005529.5A patent/CN101616893B/zh not_active Expired - Fee Related
- 2008-02-21 AU AU2008218962A patent/AU2008218962B2/en not_active Ceased
- 2008-02-21 KR KR1020097019812A patent/KR101495708B1/ko active IP Right Grant
- 2008-02-21 JP JP2009550918A patent/JP5528817B2/ja not_active Expired - Fee Related
- 2008-02-21 ES ES08725911.5T patent/ES2554646T3/es active Active
- 2008-02-21 WO PCT/US2008/002321 patent/WO2008103426A1/en active Application Filing
- 2008-02-21 US US12/070,780 patent/US7834185B2/en not_active Expired - Fee Related
- 2008-02-21 MX MX2009008527A patent/MX2009008527A/es active IP Right Grant
- 2008-02-21 EP EP08725911.5A patent/EP2121594B1/en not_active Not-in-force
- 2008-02-21 CA CA2675942A patent/CA2675942C/en not_active Expired - Fee Related
- 2008-02-21 RU RU2009135389/04A patent/RU2452728C2/ru active
-
2009
- 2009-07-16 IL IL199922A patent/IL199922A/en active IP Right Grant
-
2010
- 2010-10-06 US US12/898,858 patent/US8592453B2/en active Active
- 2010-10-06 US US12/898,861 patent/US8378121B2/en active Active
-
2013
- 2013-10-22 US US14/059,755 patent/US8802856B2/en not_active Expired - Fee Related
-
2014
- 2014-02-25 JP JP2014033710A patent/JP2014098031A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20110021787A1 (en) | 2011-01-27 |
| IL199922A (en) | 2014-08-31 |
| AU2008218962A1 (en) | 2008-08-28 |
| US8802856B2 (en) | 2014-08-12 |
| JP2010519299A (ja) | 2010-06-03 |
| EP2121594A1 (en) | 2009-11-25 |
| US7834185B2 (en) | 2010-11-16 |
| CN101616893B (zh) | 2014-01-29 |
| JP5528817B2 (ja) | 2014-06-25 |
| CA2675942C (en) | 2016-04-12 |
| JP2014098031A (ja) | 2014-05-29 |
| US8592453B2 (en) | 2013-11-26 |
| KR20090117948A (ko) | 2009-11-16 |
| RU2452728C2 (ru) | 2012-06-10 |
| US20110020231A1 (en) | 2011-01-27 |
| MX2009008527A (es) | 2009-08-27 |
| RU2009135389A (ru) | 2011-03-27 |
| US20080207736A1 (en) | 2008-08-28 |
| IL199922A0 (en) | 2010-04-15 |
| ES2554646T3 (es) | 2015-12-22 |
| WO2008103426A1 (en) | 2008-08-28 |
| CA2675942A1 (en) | 2008-02-28 |
| KR101495708B1 (ko) | 2015-02-25 |
| CN101616893A (zh) | 2009-12-30 |
| AU2008218962B2 (en) | 2013-03-14 |
| BRPI0807615A8 (pt) | 2017-12-05 |
| US8378121B2 (en) | 2013-02-19 |
| US20140051864A1 (en) | 2014-02-20 |
| EP2121594B1 (en) | 2015-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: THERAVANCE BIOPHARMA RANDD IP, LLC (US) |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |