MD3445850T2 - Metode de obținere a ARN monocatenar - Google Patents
Metode de obținere a ARN monocatenarInfo
- Publication number
- MD3445850T2 MD3445850T2 MDE20190258T MDE20190258T MD3445850T2 MD 3445850 T2 MD3445850 T2 MD 3445850T2 MD E20190258 T MDE20190258 T MD E20190258T MD E20190258 T MDE20190258 T MD E20190258T MD 3445850 T2 MD3445850 T2 MD 3445850T2
- Authority
- MD
- Moldova
- Prior art keywords
- methods
- stranded rna
- providing single
- ssrna
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
Prezenta invenţie se referă la metode pentru furnizarea de ARN monocatenar (ssARN) în plus, prezenta invenţie se referă la ssARN care poate fi obţinut prin metodele conform invenţiei şi utilizarea unui astfel de ssARN în terapie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2016059056 | 2016-04-22 | ||
PCT/EP2017/059293 WO2017182524A1 (en) | 2016-04-22 | 2017-04-19 | Methods for providing single-stranded rna |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3445850T2 true MD3445850T2 (ro) | 2022-01-31 |
Family
ID=58699087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20190258T MD3445850T2 (ro) | 2016-04-22 | 2017-04-19 | Metode de obținere a ARN monocatenar |
Country Status (26)
Country | Link |
---|---|
US (1) | US20190153425A1 (ro) |
EP (2) | EP4008782A1 (ro) |
JP (2) | JP7000343B2 (ro) |
KR (2) | KR102565881B1 (ro) |
CN (1) | CN109072232B (ro) |
AU (1) | AU2017251983B2 (ro) |
BR (1) | BR112018069417A2 (ro) |
CA (1) | CA3020481A1 (ro) |
CY (1) | CY1124845T1 (ro) |
DK (1) | DK3445850T3 (ro) |
ES (1) | ES2900272T3 (ro) |
HR (1) | HRP20211745T1 (ro) |
HU (1) | HUE059314T2 (ro) |
IL (1) | IL262304A (ro) |
LT (1) | LT3445850T (ro) |
MA (1) | MA44732B1 (ro) |
MD (1) | MD3445850T2 (ro) |
MX (1) | MX2018012880A (ro) |
PL (1) | PL3445850T3 (ro) |
PT (1) | PT3445850T (ro) |
RS (1) | RS62612B1 (ro) |
RU (2) | RU2760790C2 (ro) |
SG (2) | SG11201807573VA (ro) |
SI (1) | SI3445850T1 (ro) |
WO (1) | WO2017182524A1 (ro) |
ZA (2) | ZA201805949B (ro) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2760790C2 (ru) | 2016-04-22 | 2021-11-30 | Бионтэк Рна Фармасьютикалз Гмбх | Способы получения одноцепочечной рнк |
WO2018188730A1 (en) * | 2017-04-11 | 2018-10-18 | Biontech Rna Pharmaceuticals Gmbh | Rna for treatment of autoimmune diseases |
WO2019036685A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | METHODS FOR HPLC ANALYSIS |
CA3149497A1 (en) * | 2019-08-09 | 2021-02-18 | Nutcracker Therapeutics, Inc. | Methods and apparatuses for manufacturing for removing material from a therapeutic composition |
WO2021160346A1 (en) | 2020-02-13 | 2021-08-19 | Institut Pasteur | Nucleic acid vaccine against the sars-cov-2 coronavirus |
CA3174588A1 (en) | 2020-03-30 | 2021-10-07 | BioNTech SE | Rna compositions targeting claudin-18.2 |
EP3896160A1 (en) * | 2020-04-17 | 2021-10-20 | Bia Separations D.O.O. | A method of single-stranded rna purification |
EP3896159A1 (en) * | 2020-04-17 | 2021-10-20 | Bia Separations D.O.O. | A method of single strand rna purification employing an anion exchanger |
EP3896161A1 (en) * | 2020-04-17 | 2021-10-20 | Bia Separations D.O.O. | A method of single-stranded rna purification |
WO2021255297A1 (en) | 2020-06-19 | 2021-12-23 | Etherna Immunotherapies Nv | Rna purification method |
JP2023552678A (ja) | 2020-11-16 | 2023-12-19 | ビオンテック・ソシエタス・エウロパエア | 粒子およびmRNAを含む医薬組成物ならびにそれを調製および貯蔵する方法 |
WO2022218503A1 (en) | 2021-04-12 | 2022-10-20 | BioNTech SE | Lnp compositions comprising rna and methods for preparing, storing and using the same |
TW202237148A (zh) | 2020-11-16 | 2022-10-01 | 德商拜恩迪克公司 | 包含rna之lnp組合物以及製備、儲存及使用彼之方法 |
WO2022162027A2 (en) | 2021-01-27 | 2022-08-04 | Curevac Ag | Method of reducing the immunostimulatory properties of in vitro transcribed rna |
CN115197935A (zh) * | 2021-04-08 | 2022-10-18 | 上海细胞治疗集团有限公司 | 纤维素色谱纯化rna的方法 |
EP4322925A2 (en) | 2021-04-12 | 2024-02-21 | BioNTech SE | Rna compositions comprising a buffer substance and methods for preparing, storing and using the same |
KR20240006575A (ko) | 2021-04-26 | 2024-01-15 | 앵스띠뛰 파스퇴르 | SARS-CoV-2에 대한 사람 중화 모노클로날 항체 및 이의 용도 |
WO2022266038A1 (en) * | 2021-06-14 | 2022-12-22 | 2Seventy Bio, Inc. | Single stranded rna purification methods |
WO2022266389A1 (en) * | 2021-06-17 | 2022-12-22 | Modernatx, Inc. | Alternative rna purification strategies |
CN115505589A (zh) * | 2021-07-27 | 2022-12-23 | 上海兆维科技发展有限公司 | 一种rna的制备方法、合成蛋白质的方法以及转录反应液 |
IL309952A (en) | 2021-07-29 | 2024-03-01 | BioNTech SE | Compositions and methods for treating melanoma |
WO2023030635A1 (en) | 2021-09-02 | 2023-03-09 | BioNTech SE | Potency assay for therapeutic potential of coding nucleic acid |
WO2023036960A1 (en) | 2021-09-10 | 2023-03-16 | BioNTech SE | Lipid-based rna formulations suitable for therapy |
WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
AU2022374004A1 (en) | 2021-10-22 | 2024-05-02 | BioNTech SE | Compositions for administration of different doses of rna |
WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
AU2022380858A1 (en) * | 2021-11-08 | 2024-05-30 | Gritstone Bio, Inc. | Self-amplifying rna compositions and methods of use thereof |
WO2023083434A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Rna encoding peptidoglycan hydrolase and use thereof for treating bacterial infection |
WO2023126053A1 (en) | 2021-12-28 | 2023-07-06 | BioNTech SE | Lipid-based formulations for administration of rna |
AU2023212857A1 (en) | 2022-01-27 | 2024-07-04 | BioNTech SE | Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods |
US20230279471A1 (en) * | 2022-02-28 | 2023-09-07 | Perkinelmer Health Sciences, Inc. | Methods for separating and detecting double-stranded and single-stranded ribonucleic acid (rna) |
WO2023165681A1 (en) | 2022-03-01 | 2023-09-07 | BioNTech SE | Rna lipid nanoparticles (lnps) comprising a polyoxazoline and/or polyoxazine polymer |
KR20230142248A (ko) | 2022-04-01 | 2023-10-11 | 주식회사 엘지에너지솔루션 | 연성회로기판을 포함하는 파우치형 전지셀 |
WO2023193892A1 (en) | 2022-04-05 | 2023-10-12 | BioNTech SE | Nucleic acid compositions comprising an inorganic polyphosphate and methods for preparing, storing and using the same |
WO2023218431A1 (en) | 2022-05-13 | 2023-11-16 | BioNTech SE | Rna compositions targeting hiv |
CN114921457B (zh) * | 2022-05-16 | 2023-09-29 | 硅羿科技(上海)有限公司 | 一种提取dsRNA的方法 |
WO2023230295A1 (en) | 2022-05-25 | 2023-11-30 | BioNTech SE | Rna compositions for delivery of monkeypox antigens and related methods |
WO2024017479A1 (en) | 2022-07-21 | 2024-01-25 | BioNTech SE | Multifunctional cells transiently expressing an immune receptor and one or more cytokines, their use and methods for their production |
WO2024028325A1 (en) | 2022-08-01 | 2024-02-08 | BioNTech SE | Nucleic acid compositions comprising amphiphilic oligo ethylene glycol (oeg)-conjugated compounds and methods of using such compounds and compositions |
WO2024028445A1 (en) | 2022-08-03 | 2024-02-08 | BioNTech SE | Rna for preventing or treating tuberculosis |
WO2024027910A1 (en) | 2022-08-03 | 2024-02-08 | BioNTech SE | Rna for preventing or treating tuberculosis |
WO2024063789A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of malaria antigens and related methods |
WO2024064934A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of plasmodium csp antigens and related methods |
WO2024063788A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of malaria antigens and related methods |
WO2024064931A1 (en) | 2022-09-23 | 2024-03-28 | BioNTech SE | Compositions for delivery of liver stage antigens and related methods |
WO2024074634A1 (en) | 2022-10-06 | 2024-04-11 | BioNTech SE | Rna compositions targeting claudin-18.2 |
WO2024074211A1 (en) | 2022-10-06 | 2024-04-11 | BioNTech SE | Rna compositions targeting claudin-18.2 |
WO2024141955A1 (en) | 2022-12-28 | 2024-07-04 | BioNTech SE | Rna compositions targeting hiv |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2936240A1 (de) * | 1979-09-07 | 1981-03-26 | Bayer Ag, 51373 Leverkusen | Verfahren zur herstellung bekannter und neuer 6-amino-6-desoxy-2,3-0-isopropyliden-(alpha)-l-sorbofuranose-derivate sowie neue zwischenprodukte des verfahrens |
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
NL8900725A (nl) * | 1989-03-23 | 1990-10-16 | Az Univ Amsterdam | Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur. |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
IL151928A0 (en) | 2000-03-30 | 2003-04-10 | Whitehead Biomedical Inst | Rna sequence-specific mediators of rna interference |
JP3692395B2 (ja) * | 2000-09-01 | 2005-09-07 | 独立行政法人農業・生物系特定産業技術研究機構 | ベクターモノカリオンを用いた紫紋羽病菌に対するゲノムが2本鎖rnaである糸状菌に寄生するウイルスを導入する新規方法 |
WO2005012487A2 (en) * | 2003-08-01 | 2005-02-10 | Invitrogen Corporation | Compositions and methods for preparing short rna molecules and other nucleic acids |
DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
CN101086011B (zh) * | 2006-06-08 | 2010-12-08 | 河南农业大学 | 食用菌和植物双链rna病毒检测试剂盒及其应用 |
DE102006061015A1 (de) | 2006-12-22 | 2008-06-26 | Curevac Gmbh | Verfahren zur Reinigung von RNA im präparativen Maßstab mittels HPLC |
PT2167523E (pt) | 2007-06-19 | 2014-09-22 | Univ Louisiana State | Síntese e utilização de análogos fosforotiolato antireversos do capuz de arn mensageiro |
US8808982B2 (en) | 2009-12-07 | 2014-08-19 | Cellscript, Llc | Compositions and methods for reprogramming eukaryotic cells |
DK3421601T3 (da) | 2011-12-30 | 2020-02-24 | Cellscript Llc | Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt |
EP3744843A1 (en) * | 2015-05-29 | 2020-12-02 | CureVac Real Estate GmbH | A method for producing and purifying rna, comprising at least one step of tangential flow filtration |
RU2760790C2 (ru) | 2016-04-22 | 2021-11-30 | Бионтэк Рна Фармасьютикалз Гмбх | Способы получения одноцепочечной рнк |
-
2017
- 2017-04-19 RU RU2018136601A patent/RU2760790C2/ru active
- 2017-04-19 RS RS20211459A patent/RS62612B1/sr unknown
- 2017-04-19 HU HUE17722695A patent/HUE059314T2/hu unknown
- 2017-04-19 PT PT177226958T patent/PT3445850T/pt unknown
- 2017-04-19 RU RU2021134269A patent/RU2021134269A/ru unknown
- 2017-04-19 WO PCT/EP2017/059293 patent/WO2017182524A1/en active Application Filing
- 2017-04-19 SG SG11201807573VA patent/SG11201807573VA/en unknown
- 2017-04-19 EP EP21204500.9A patent/EP4008782A1/en active Pending
- 2017-04-19 SG SG10202010471UA patent/SG10202010471UA/en unknown
- 2017-04-19 MA MA44732A patent/MA44732B1/fr unknown
- 2017-04-19 EP EP17722695.8A patent/EP3445850B1/en active Active
- 2017-04-19 PL PL17722695T patent/PL3445850T3/pl unknown
- 2017-04-19 US US16/091,389 patent/US20190153425A1/en active Pending
- 2017-04-19 JP JP2018555164A patent/JP7000343B2/ja active Active
- 2017-04-19 KR KR1020227009308A patent/KR102565881B1/ko active IP Right Grant
- 2017-04-19 ES ES17722695T patent/ES2900272T3/es active Active
- 2017-04-19 MD MDE20190258T patent/MD3445850T2/ro unknown
- 2017-04-19 MX MX2018012880A patent/MX2018012880A/es unknown
- 2017-04-19 CA CA3020481A patent/CA3020481A1/en active Pending
- 2017-04-19 BR BR112018069417A patent/BR112018069417A2/pt not_active IP Right Cessation
- 2017-04-19 LT LTEPPCT/EP2017/059293T patent/LT3445850T/lt unknown
- 2017-04-19 HR HRP20211745TT patent/HRP20211745T1/hr unknown
- 2017-04-19 SI SI201730980T patent/SI3445850T1/sl unknown
- 2017-04-19 CN CN201780024328.9A patent/CN109072232B/zh active Active
- 2017-04-19 AU AU2017251983A patent/AU2017251983B2/en active Active
- 2017-04-19 KR KR1020187030368A patent/KR102378404B1/ko active IP Right Grant
- 2017-04-19 DK DK17722695.8T patent/DK3445850T3/da active
-
2018
- 2018-09-05 ZA ZA2018/05949A patent/ZA201805949B/en unknown
- 2018-10-11 IL IL262304A patent/IL262304A/en unknown
-
2019
- 2019-08-22 ZA ZA2019/05536A patent/ZA201905536B/en unknown
-
2021
- 2021-11-26 CY CY20211101032T patent/CY1124845T1/el unknown
- 2021-12-23 JP JP2021209047A patent/JP7335313B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD3445850T2 (ro) | Metode de obținere a ARN monocatenar | |
CY1124663T1 (el) | Αντιιικα παραγωγα ν4-υδροξυκυτιδινης | |
JOP20200192A1 (ar) | أجسام مضادة لـ tigit | |
PH12015501648A1 (en) | 2-aminopyrimidine derivatives for the treatment of viral infections | |
EA201790273A1 (ru) | Флагеллиновые композиции и их применение | |
EA201692529A1 (ru) | Способы и композиции для лечения расстройств с использованием фоллистатиновых полипептидов | |
EA201690280A1 (ru) | Композиции и способы, относящиеся к выделенным эндофитам | |
EA202090547A3 (ru) | Макроциклические деаза-оксипурины для лечения вирусных инфекций | |
EA201692473A1 (ru) | Способы получения замещенных нуклеотидных аналогов | |
EA201591761A1 (ru) | Композиции на основе наночастиц | |
EA201991997A1 (ru) | Комбинированная терапия | |
MX2021010060A (es) | Produccion de virus en huevos aviares. | |
PH12016502047A1 (en) | Niacinamide for including generation of antimicrobial peptides | |
EA201792612A1 (ru) | 6-аминохинолин-3-карбонитрилы в качестве модуляторов cot | |
MY191539A (en) | Streptococcal vaccine | |
MX2017000306A (es) | Metodos para tratar hipotension. | |
EA201692518A2 (ru) | Способы улучшения производительности миокарда у пациентов после операции фонтена с применением композиций уденафила | |
EA202090270A1 (ru) | Новые замещенные производные ксантина | |
UY34564A (es) | Utilización en terapéutica de derivados de imidazopiridina | |
EA201690709A1 (ru) | Применение одипарцила в лечении мукополисахаридоза | |
PH12018500339A1 (en) | Lysobactin for use in the treatment of bovine mastitis | |
EA201991471A1 (ru) | Способы введения гепсидина | |
TWD173906S (zh) | 眼鏡之部分 | |
TWD173905S (zh) | 眼鏡之部分 |