MD3442972T2 - Inhibitori ai bromodomeniului - Google Patents

Inhibitori ai bromodomeniului

Info

Publication number
MD3442972T2
MD3442972T2 MDE20190228T MDE20190228T MD3442972T2 MD 3442972 T2 MD3442972 T2 MD 3442972T2 MD E20190228 T MDE20190228 T MD E20190228T MD E20190228 T MDE20190228 T MD E20190228T MD 3442972 T2 MD3442972 T2 MD 3442972T2
Authority
MD
Moldova
Prior art keywords
bromodomain inhibitors
formula
compounds
diseases
aids
Prior art date
Application number
MDE20190228T
Other languages
English (en)
Inventor
Steven D Fidanze
Lisa A Hasvold
Dachun Liu
Keith F Mcdaniel
John PRATT
Michael Schrimpf
George S Sheppard
Le Wang
Bing Li
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MD3442972T2 publication Critical patent/MD3442972T2/ro

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Prezenta invenţie furnizează compuşi cu formula (I) în care R1, R2, R3, R4, R6, X1 şi X2 au oricare din valorile definite în specificaţie, şi săruri acceptabile farmaceutic ale acestora, care sunt utili ca agenţi în tratamentul bolilor şi afecţiunilor, incluzȃnd bolile inflamatorii, cancerul, şi SIDA. Sunt de asemenea furnizate compoziţii farmaceutice care cuprind compuşi cu formula (I).
MDE20190228T 2016-04-15 2017-04-14 Inhibitori ai bromodomeniului MD3442972T2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016079362 2016-04-15
PCT/CN2017/080511 WO2017177955A1 (en) 2016-04-15 2017-04-14 Bromodomain inhibitors

Publications (1)

Publication Number Publication Date
MD3442972T2 true MD3442972T2 (ro) 2020-08-31

Family

ID=60042835

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20190228T MD3442972T2 (ro) 2016-04-15 2017-04-14 Inhibitori ai bromodomeniului

Country Status (38)

Country Link
US (3) US10633379B2 (ro)
EP (2) EP3442972B1 (ro)
JP (2) JP6978424B2 (ro)
KR (1) KR102250415B1 (ro)
CN (1) CN109071534B (ro)
AR (1) AR108207A1 (ro)
AU (2) AU2017251537B2 (ro)
BR (1) BR112018071216A2 (ro)
CA (1) CA3018802A1 (ro)
CL (1) CL2018002924A1 (ro)
CO (1) CO2018011064A2 (ro)
CR (1) CR20180541A (ro)
CY (1) CY1123025T1 (ro)
DK (1) DK3442972T3 (ro)
DO (1) DOP2018000227A (ro)
EC (1) ECSP18083519A (ro)
ES (1) ES2793239T3 (ro)
HR (1) HRP20200728T1 (ro)
HU (1) HUE050217T2 (ro)
IL (1) IL261586B (ro)
LT (1) LT3442972T (ro)
MA (2) MA44674B1 (ro)
MD (1) MD3442972T2 (ro)
ME (1) ME03759B (ro)
MX (1) MX2018012541A (ro)
MY (1) MY190795A (ro)
PE (1) PE20190472A1 (ro)
PH (1) PH12018501920B1 (ro)
PL (1) PL3442972T3 (ro)
PT (1) PT3442972T (ro)
RS (1) RS60302B1 (ro)
RU (1) RU2741808C2 (ro)
SG (1) SG11201808003RA (ro)
SI (1) SI3442972T1 (ro)
TW (3) TW202304907A (ro)
UA (1) UA124764C2 (ro)
UY (1) UY37205A (ro)
WO (1) WO2017177955A1 (ro)

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AU2017251537B2 (en) * 2016-04-15 2020-10-08 Abbvie Inc. Bromodomain inhibitors
WO2018068283A1 (en) * 2016-10-14 2018-04-19 Abbvie Inc. Bromodomain inhibitors
CA3060416A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
EP3828183A4 (en) * 2018-07-25 2022-03-09 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. SULFOXIMINE COMPOUND AS BROMO-DOMAIN INHIBITOR AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
CN110964012B (zh) * 2018-09-29 2021-08-13 上海凌达生物医药有限公司 一类稠杂环联芳基苄醇类化合物、制备方法和用途
US11192900B2 (en) 2018-10-30 2021-12-07 Nuvation Bio Inc. Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
CN111704610B (zh) * 2019-03-17 2022-03-22 上海凌达生物医药有限公司 一类吡咯酰胺并吡啶酮类化合物、制备方法和用途
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
WO2020232214A1 (en) * 2019-05-14 2020-11-19 Abbvie Inc. Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor
CA3145827A1 (en) 2019-07-02 2021-01-07 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
CN112625036A (zh) * 2019-10-08 2021-04-09 上海海和药物研究开发股份有限公司 一类具有brd4抑制活性的化合物、其制备方法及用途
GB202016977D0 (en) 2020-10-26 2020-12-09 In4Derm Ltd Compounds
WO2022116968A1 (zh) * 2020-12-01 2022-06-09 成都苑东生物制药股份有限公司 一种新型n-杂环bet溴结构域抑制剂、其制备方法及医药用途
CN115551861A (zh) * 2021-04-30 2022-12-30 成都苑东生物制药股份有限公司 一种新型brd4溴结构域protac蛋白降解剂、其制备方法及医药用途
GB2621505A (en) 2021-06-29 2024-02-14 Tay Therapeutics Ltd Pyrrolopyridone derivatives useful in the treatment of cancer
CN115611890A (zh) * 2021-07-15 2023-01-17 成都苑东生物制药股份有限公司 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途

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