MA49043A - Formulation stable d'anticorps - Google Patents
Formulation stable d'anticorpsInfo
- Publication number
- MA49043A MA49043A MA049043A MA49043A MA49043A MA 49043 A MA49043 A MA 49043A MA 049043 A MA049043 A MA 049043A MA 49043 A MA49043 A MA 49043A MA 49043 A MA49043 A MA 49043A
- Authority
- MA
- Morocco
- Prior art keywords
- antibody formulation
- stable antibody
- stable
- formulation
- antibody
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762482270P | 2017-04-06 | 2017-04-06 | |
PCT/US2018/024032 WO2018187057A1 (fr) | 2017-04-06 | 2018-03-23 | Formulation stable d'anticorps |
Publications (2)
Publication Number | Publication Date |
---|---|
MA49043A true MA49043A (fr) | 2020-02-12 |
MA49043B1 MA49043B1 (fr) | 2023-11-30 |
Family
ID=62028099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA49043A MA49043B1 (fr) | 2017-04-06 | 2018-03-23 | Formulation stable d'anticorps |
Country Status (28)
Country | Link |
---|---|
US (2) | US11603407B2 (fr) |
EP (2) | EP3606504B1 (fr) |
JP (1) | JP7229171B2 (fr) |
CN (1) | CN110709062B (fr) |
AR (1) | AR111455A1 (fr) |
AU (1) | AU2018247501A1 (fr) |
BR (1) | BR112019020246A2 (fr) |
CA (1) | CA3059087A1 (fr) |
CL (1) | CL2019002828A1 (fr) |
CO (1) | CO2019011021A2 (fr) |
DK (1) | DK3606504T3 (fr) |
EA (1) | EA201992377A1 (fr) |
ES (1) | ES2955062T3 (fr) |
FI (1) | FI3606504T3 (fr) |
HR (1) | HRP20231282T1 (fr) |
HU (1) | HUE063509T2 (fr) |
IL (1) | IL269499A (fr) |
LT (1) | LT3606504T (fr) |
MA (1) | MA49043B1 (fr) |
MX (1) | MX2019011207A (fr) |
PH (1) | PH12019502123A1 (fr) |
PL (1) | PL3606504T3 (fr) |
PT (1) | PT3606504T (fr) |
RS (1) | RS64680B1 (fr) |
SG (2) | SG10202111008QA (fr) |
SI (1) | SI3606504T1 (fr) |
TW (1) | TWI795396B (fr) |
WO (1) | WO2018187057A1 (fr) |
Families Citing this family (27)
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TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
EP3585812A1 (fr) | 2017-02-21 | 2020-01-01 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-pd-1 pour le traitement du cancer du poumon |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
WO2020097141A1 (fr) | 2018-11-07 | 2020-05-14 | Merck Sharp & Dohme Corp. | Formulations stables d'anticorps du récepteur de mort programmé 1 (mp-1) et leurs méthodes d'utilisation |
FI3880186T3 (fi) | 2018-11-14 | 2024-05-30 | Regeneron Pharmaceuticals Inc | PD-1-inhibiittoreiden intralesionaalinen antaminen ihosyövän hoitamiseksi |
JP7266108B2 (ja) | 2019-02-18 | 2023-04-27 | イーライ リリー アンド カンパニー | 治療用抗体製剤 |
CA3137361A1 (fr) | 2019-02-28 | 2020-09-03 | Regeneron Pharmaceuticals, Inc. | Administration d'inhibiteurs de pd-1 pour le traitement du cancer de la peau |
WO2020180727A1 (fr) | 2019-03-06 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer |
US20200369760A1 (en) * | 2019-05-24 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-angptl3 antibodies |
JP2022552152A (ja) * | 2019-10-02 | 2022-12-15 | アラマブ セラピューティクス, インコーポレイテッド | 抗コネキシン抗体製剤 |
EP4055033A4 (fr) * | 2019-11-04 | 2023-12-06 | Inovio Pharmaceuticals, Inc. | Polythérapie pour traiter le cancer du cerveau |
WO2021096278A1 (fr) * | 2019-11-15 | 2021-05-20 | 삼성바이오에피스 주식회사 | Composition en phase liquide pour médicament à base d'anticorps |
EP4076385A1 (fr) | 2019-12-20 | 2022-10-26 | Formycon AG | Formulations d'anticorps anti-pd1 |
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JP7240512B2 (ja) | 2020-05-26 | 2023-03-15 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Pd-1阻害剤を投与することにより子宮頸がんを処置する方法 |
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IL304945A (en) | 2021-02-11 | 2023-10-01 | Regeneron Pharma | Methods for treating cancer by administering a PD-1 inhibitor as adjuvant therapy |
IL304998A (en) | 2021-02-23 | 2023-10-01 | Regeneron Pharma | Methods for the treatment of lung cancer through the administration of a PD-1 inhibitor |
EP4313123A1 (fr) | 2021-03-23 | 2024-02-07 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement du cancer chez des patients immunodéprimés ou immunovulnérables par administration d'un inhibiteur de pd-1 |
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WO2023198116A1 (fr) * | 2022-04-14 | 2023-10-19 | Beigene Switzerland Gmbh | Formulations stables d'arginine à haute concentration contenant un anticorps pd -1 et leurs procédés d'utilisation |
WO2023198115A1 (fr) * | 2022-04-14 | 2023-10-19 | Beigene Switzerland Gmbh | Formulations stables de chlorure de sodium à haute concentration contenant un anticorps pd-1 et leurs procédés d'utilisation |
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