MA43347A - Compositions et méthodes permettant d'inhiber l'expression du gène de lpa - Google Patents
Compositions et méthodes permettant d'inhiber l'expression du gène de lpaInfo
- Publication number
- MA43347A MA43347A MA43347A MA43347A MA43347A MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A MA 43347 A MA43347 A MA 43347A
- Authority
- MA
- Morocco
- Prior art keywords
- agents
- arni
- lpa
- compositions
- methods
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 3
- 101150091521 lpa gene Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 241000320892 Clerodendrum phlomidis Species 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 102100040214 Apolipoprotein(a) Human genes 0.000 abstract 1
- 101710115418 Apolipoprotein(a) Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000009368 gene silencing by RNA Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Des agents d'interférence d'arn (arni) et des conjugués d'agents d'arni pour inhiber l'expression du gène de la lpa (apo (a)) sont décrits. Des compositions pharmaceutiques comprenant un ou plusieurs agents arni lpa, éventuellement avec un ou plusieurs agents thérapeutiques supplémentaires, sont également décrites. La délivrance des agents arni lpa décrits aux cellules hépatiques in vivo permet d'inhiber l'expression du gène lpa et le traitement des maladies cardiovasculaires et cardiovasculaires.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562235816P | 2015-10-01 | 2015-10-01 | |
US201662346304P | 2016-06-06 | 2016-06-06 | |
US201662383221P | 2016-09-02 | 2016-09-02 | |
PCT/US2016/054729 WO2017059223A2 (fr) | 2015-10-01 | 2016-09-30 | Compositions et méthodes permettant d'inhiber l'expression du gène de lpa |
Publications (2)
Publication Number | Publication Date |
---|---|
MA43347A true MA43347A (fr) | 2018-08-08 |
MA43347B1 MA43347B1 (fr) | 2021-11-30 |
Family
ID=58424351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA43347A MA43347B1 (fr) | 2015-10-01 | 2017-04-06 | Compositions et méthodes permettant d'inhiber l'expression du gène de lpa |
Country Status (37)
Country | Link |
---|---|
US (3) | US9932586B2 (fr) |
EP (2) | EP4029941A1 (fr) |
JP (4) | JP6991966B2 (fr) |
KR (1) | KR20180052703A (fr) |
CN (1) | CN108368506A (fr) |
AU (2) | AU2016331084B2 (fr) |
BR (1) | BR112018006489A2 (fr) |
CA (1) | CA3000397A1 (fr) |
CL (1) | CL2018000803A1 (fr) |
CO (1) | CO2018003678A2 (fr) |
CR (1) | CR20180231A (fr) |
CY (1) | CY1125263T1 (fr) |
DK (1) | DK3356529T3 (fr) |
EA (1) | EA038478B1 (fr) |
ES (1) | ES2896298T3 (fr) |
HK (1) | HK1259063A1 (fr) |
HR (1) | HRP20211410T1 (fr) |
HU (1) | HUE055942T2 (fr) |
IL (3) | IL300438A (fr) |
JO (2) | JOP20210043A1 (fr) |
LT (1) | LT3356529T (fr) |
MA (1) | MA43347B1 (fr) |
MX (2) | MX2018003833A (fr) |
MY (1) | MY195796A (fr) |
PE (1) | PE20181139A1 (fr) |
PH (1) | PH12018500713A1 (fr) |
PL (1) | PL3356529T3 (fr) |
PT (1) | PT3356529T (fr) |
RS (1) | RS62523B1 (fr) |
SG (1) | SG10202008530TA (fr) |
SI (1) | SI3356529T1 (fr) |
TN (1) | TN2018000094A1 (fr) |
TW (2) | TWI784934B (fr) |
UA (1) | UA121998C2 (fr) |
UY (1) | UY36926A (fr) |
WO (1) | WO2017059223A2 (fr) |
ZA (1) | ZA202106265B (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7718133B2 (en) | 2003-10-09 | 2010-05-18 | 3M Innovative Properties Company | Multilayer processing devices and methods |
AU2017229469B2 (en) * | 2016-03-07 | 2023-02-23 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands for therapeutic compounds |
BR112019004178A2 (pt) * | 2016-09-02 | 2019-05-28 | Arrowhead Pharmaceuticals Inc | ligantes de alvejamento |
RS63836B1 (sr) | 2017-04-05 | 2023-01-31 | Silence Therapeutics Gmbh | Proizvodi i sastavi |
CA3061752A1 (fr) * | 2017-07-06 | 2019-01-10 | Arrowhead Pharmaceuticals, Inc. | Agents arni d'inhibition d'expression de gene alpha-enac et methodes d'utilisation |
EP3681516A4 (fr) * | 2017-09-11 | 2021-09-29 | Arrowhead Pharmaceuticals, Inc. | Agents d'interférence arn et compositions destinés à inhiber l'expression de l'apolipoprotéine c-iii (apoc3) |
US10995335B2 (en) * | 2017-09-14 | 2021-05-04 | Arrowhead Pharmaceuticals, Inc. | RNAi agents and compositions for inhibiting expression of angiopoietin-like 3 (ANGPTL3), and methods of use |
CA3079413A1 (fr) * | 2017-10-17 | 2019-04-25 | Arrowhead Pharmaceuticals, Inc. | Agents a base d'arni et compositions destinees a inhiber l'expression du recepteur 1 de l'asialoglycoproteine |
EP3483270A1 (fr) * | 2017-11-13 | 2019-05-15 | Silence Therapeutics GmbH | Produits et compositions |
SG11202003230UA (en) * | 2017-11-13 | 2020-05-28 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of lpa in a cell |
CR20210186A (es) * | 2018-09-19 | 2021-06-14 | Arrowhead Pharmaceuticals Inc | Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso |
ES2932295T3 (es) | 2018-11-13 | 2023-01-17 | Silence Therapeutics Gmbh | Acidos nucleicos para inhibir la expresión de LPA en una célula |
AU2020399636A1 (en) | 2019-12-09 | 2022-06-02 | Amgen Inc. | RNAi constructs and methods for inhibiting LPA expression |
TW202220673A (zh) * | 2020-08-05 | 2022-06-01 | 美商戴瑟納製藥股份有限公司 | 抑制lpa表現之組合物及方法 |
EP4229201A1 (fr) * | 2020-10-16 | 2023-08-23 | Sanofi | Compositions d'arn et méthodes d'inhibition de lipoprotéine (a) |
KR20230104200A (ko) | 2020-11-05 | 2023-07-07 | 암젠 인크 | LPA-표적화된 RNAi 작제물을 이용하여 죽상경화성 심혈관질환을 치료하는 방법 |
WO2022121959A1 (fr) * | 2020-12-09 | 2022-06-16 | 纳肽得有限公司 | Molécule d'arnsi et son application dans le traitement de maladies des artères coronaires |
JP2024500035A (ja) | 2020-12-23 | 2024-01-04 | アルゴノート アールエヌエー リミテッド | 心血管疾患の治療 |
US11649260B2 (en) | 2021-06-18 | 2023-05-16 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine nucleosides |
US11692001B2 (en) | 2021-08-30 | 2023-07-04 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
WO2023041508A2 (fr) | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Traitement d'une maladie cardiovasculaire |
WO2023041079A1 (fr) * | 2021-09-18 | 2023-03-23 | 上海金中锘美生物医药科技有限公司 | Inhibiteur de lpa et son utilisation |
US11993626B2 (en) | 2021-12-15 | 2024-05-28 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024032681A1 (fr) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | Procédé pour cible d'édition d'épitope et utilisation |
CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
AU767195B2 (en) | 1999-03-10 | 2003-11-06 | Phogen Limited | Delivery of substances to cells |
EP1873259B1 (fr) * | 2000-12-01 | 2012-01-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Interférence ARN à médiation par ARN 21 et 22nt |
US7227014B2 (en) | 2001-08-07 | 2007-06-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein (a) expression |
US7259150B2 (en) * | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
JP2006523209A (ja) | 2003-03-12 | 2006-10-12 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | アペリン組成物によって血管新生を調節するための方法 |
WO2005089287A2 (fr) | 2004-03-15 | 2005-09-29 | City Of Hope | Procedes et compositions pour l'inhibition specifique de l'expression genetique par l'arn double brin |
CN101500548A (zh) * | 2006-08-18 | 2009-08-05 | 弗·哈夫曼-拉罗切有限公司 | 用于体内递送多核苷酸的多缀合物 |
WO2010080129A2 (fr) | 2008-12-18 | 2010-07-15 | Dicerna Pharmaceuticals, Inc. | Agents allongés servant de substrats de dicer et procédés d'inhibition spécifique de l'expression d'un gène |
WO2010093788A2 (fr) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Molécules d'arn interférence substrats de dicer multiplexes ayant des séquences de jonction |
ES2562817T3 (es) | 2010-02-24 | 2016-03-08 | Arrowhead Research Corporation | Composiciones para el suministro dirigido de ARNip |
WO2011141703A1 (fr) * | 2010-05-12 | 2011-11-17 | Protiva Biotherapeutics Inc. | Compositions et procédés pour réduire au silence l'apolipoprotéine b |
JP2014504295A (ja) | 2010-12-17 | 2014-02-20 | アローヘッド リサーチ コーポレイション | siRNA用ガラクトースクラスター−薬物動態調節剤標的指向部分 |
US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
JP5941926B2 (ja) | 2010-12-29 | 2016-06-29 | アローヘッド リサーチ コーポレイション | 酵素感受性連結を有するインビボポリヌクレオチド送達結合体 |
MX2014001971A (es) | 2011-08-26 | 2014-03-31 | Arrowhead Res Corp | Polimeros de poli(vinilester) para suministro de acido nucleico in vivo. |
KR102095699B1 (ko) * | 2011-11-18 | 2020-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스티레틴(TTR) 관련 질병을 치료하기 위한 RNAi 제제, 조성 및 그의 사용방법 |
CN103764153A (zh) | 2012-04-18 | 2014-04-30 | 箭头研究公司 | 用于体内核酸递送的聚(丙烯酸酯)聚合物 |
LT2855500T (lt) | 2012-05-24 | 2020-11-10 | Ionis Pharmaceuticals, Inc. | Būdai ir kompozicijos, skirti apolipoproteino (a) raiškos moduliacijai |
EP2991661B1 (fr) | 2013-05-01 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Composés antisens conjugués et leur utilisation |
WO2016149020A1 (fr) * | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Agents d'interférence arn |
EP3302503A4 (fr) | 2015-05-29 | 2019-08-07 | Arrowhead Pharmaceuticals, Inc. | Compositions et méthodes permettant d'inhiber l'expression du gène de hif2alpha |
MY195720A (en) * | 2015-07-31 | 2023-02-07 | Alnylam Pharmaceuticals Inc | Transthyretin (Ttr) Irna Compositions and Methods of Use Thereof for Treating or Preventing Ttr-Associated Diseases |
AU2017229469B2 (en) | 2016-03-07 | 2023-02-23 | Arrowhead Pharmaceuticals, Inc. | Targeting ligands for therapeutic compounds |
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2015
- 2015-10-01 JO JOP/2021/0043A patent/JOP20210043A1/ar unknown
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2016
- 2016-09-28 JO JOP/2016/0211A patent/JOP20160211B1/ar active
- 2016-09-30 PT PT168526952T patent/PT3356529T/pt unknown
- 2016-09-30 EA EA201890864A patent/EA038478B1/ru unknown
- 2016-09-30 EP EP21191363.7A patent/EP4029941A1/fr active Pending
- 2016-09-30 CN CN201680057095.8A patent/CN108368506A/zh active Pending
- 2016-09-30 UY UY0001036926A patent/UY36926A/es unknown
- 2016-09-30 AU AU2016331084A patent/AU2016331084B2/en active Active
- 2016-09-30 TW TW105131823A patent/TWI784934B/zh active
- 2016-09-30 MY MYPI2018000440A patent/MY195796A/en unknown
- 2016-09-30 SG SG10202008530TA patent/SG10202008530TA/en unknown
- 2016-09-30 TW TW111141660A patent/TWI836693B/zh active
- 2016-09-30 CA CA3000397A patent/CA3000397A1/fr active Pending
- 2016-09-30 MX MX2018003833A patent/MX2018003833A/es unknown
- 2016-09-30 HR HRP20211410TT patent/HRP20211410T1/hr unknown
- 2016-09-30 DK DK16852695.2T patent/DK3356529T3/da active
- 2016-09-30 HU HUE16852695A patent/HUE055942T2/hu unknown
- 2016-09-30 US US15/281,309 patent/US9932586B2/en active Active
- 2016-09-30 PE PE2018000487A patent/PE20181139A1/es unknown
- 2016-09-30 TN TNP/2018/000094A patent/TN2018000094A1/en unknown
- 2016-09-30 WO PCT/US2016/054729 patent/WO2017059223A2/fr active Application Filing
- 2016-09-30 UA UAA201804593A patent/UA121998C2/uk unknown
- 2016-09-30 SI SI201631374T patent/SI3356529T1/sl unknown
- 2016-09-30 IL IL300438A patent/IL300438A/en unknown
- 2016-09-30 JP JP2018516738A patent/JP6991966B2/ja active Active
- 2016-09-30 KR KR1020187010095A patent/KR20180052703A/ko not_active Application Discontinuation
- 2016-09-30 RS RS20211351A patent/RS62523B1/sr unknown
- 2016-09-30 BR BR112018006489-0A patent/BR112018006489A2/pt active Search and Examination
- 2016-09-30 PL PL16852695T patent/PL3356529T3/pl unknown
- 2016-09-30 LT LTEPPCT/US2016/054729T patent/LT3356529T/lt unknown
- 2016-09-30 CR CR20180231A patent/CR20180231A/es unknown
- 2016-09-30 ES ES16852695T patent/ES2896298T3/es active Active
- 2016-09-30 EP EP16852695.2A patent/EP3356529B1/fr active Active
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2017
- 2017-04-06 MA MA43347A patent/MA43347B1/fr unknown
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2018
- 2018-02-21 US US15/901,810 patent/US10662427B2/en active Active
- 2018-03-25 IL IL258333A patent/IL258333B/en unknown
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