MA43169B1 - Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma - Google Patents

Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma

Info

Publication number
MA43169B1
MA43169B1 MA43169A MA43169A MA43169B1 MA 43169 B1 MA43169 B1 MA 43169B1 MA 43169 A MA43169 A MA 43169A MA 43169 A MA43169 A MA 43169A MA 43169 B1 MA43169 B1 MA 43169B1
Authority
MA
Morocco
Prior art keywords
pi3k
heterocyclic compounds
gamma inhibitors
inhibitors
diseases
Prior art date
Application number
MA43169A
Other languages
English (en)
Other versions
MA43169A (fr
Inventor
Nikoo Falahatpisheh
Andrew P Combs
Richard B Sparks
Artem Shvartsbart
Stacey Shepard
Lixin Shao
Ge Zou
Andrew W Buesking
Eddy W Yue
Ravi Jalluri
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MA43169A publication Critical patent/MA43169A/fr
Publication of MA43169B1 publication Critical patent/MA43169B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La présente invention concerne des composés de formule (i), ou des sels ou stéréoisomères de ceux-ci pharmaceutiquement acceptables, qui sont des inhibiteurs de pi3k-?, utiles pour le traitement de troubles tels que des maladies auto-immunes, le cancer, des maladies cardiovasculaires et des maladies neurodégénératives.
MA43169A 2015-11-06 2016-11-04 Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma MA43169B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562252050P 2015-11-06 2015-11-06
PCT/US2016/060468 WO2017079519A1 (fr) 2015-11-06 2016-11-04 Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma

Publications (2)

Publication Number Publication Date
MA43169A MA43169A (fr) 2018-09-12
MA43169B1 true MA43169B1 (fr) 2022-05-31

Family

ID=57460598

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43169A MA43169B1 (fr) 2015-11-06 2016-11-04 Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma

Country Status (17)

Country Link
US (4) US10065963B2 (fr)
EP (2) EP4086259A1 (fr)
JP (1) JP6854817B2 (fr)
AR (1) AR106595A1 (fr)
DK (1) DK3371190T3 (fr)
ES (1) ES2915550T3 (fr)
HR (1) HRP20220599T1 (fr)
HU (1) HUE059324T2 (fr)
LT (1) LT3371190T (fr)
MA (1) MA43169B1 (fr)
MD (1) MD3371190T2 (fr)
PL (1) PL3371190T3 (fr)
PT (1) PT3371190T (fr)
RS (1) RS63359B1 (fr)
SI (1) SI3371190T1 (fr)
TW (2) TWI744256B (fr)
WO (1) WO2017079519A1 (fr)

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Also Published As

Publication number Publication date
HRP20220599T1 (hr) 2022-06-24
LT3371190T (lt) 2022-08-10
AR106595A1 (es) 2018-01-31
PT3371190T (pt) 2022-07-08
JP2018532760A (ja) 2018-11-08
RS63359B1 (sr) 2022-07-29
US20190062336A1 (en) 2019-02-28
HUE059324T2 (hu) 2022-11-28
TW201726679A (zh) 2017-08-01
MA43169A (fr) 2018-09-12
DK3371190T3 (da) 2022-05-23
TWI744256B (zh) 2021-11-01
EP4086259A1 (fr) 2022-11-09
US10472368B2 (en) 2019-11-12
US11773102B2 (en) 2023-10-03
US10065963B2 (en) 2018-09-04
US11091491B2 (en) 2021-08-17
US20200031837A1 (en) 2020-01-30
US20230009843A1 (en) 2023-01-12
MD3371190T2 (ro) 2022-09-30
TW202204362A (zh) 2022-02-01
JP6854817B2 (ja) 2021-04-07
SI3371190T1 (sl) 2022-08-31
EP3371190A1 (fr) 2018-09-12
WO2017079519A1 (fr) 2017-05-11
PL3371190T3 (pl) 2022-11-07
EP3371190B1 (fr) 2022-03-30
TWI824309B (zh) 2023-12-01
ES2915550T3 (es) 2022-06-23
US20170129899A1 (en) 2017-05-11

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