MA40583A - Nouveaux activateurs de la guanylate cyclase soluble et leur utilisation - Google Patents
Nouveaux activateurs de la guanylate cyclase soluble et leur utilisationInfo
- Publication number
- MA40583A MA40583A MA040583A MA40583A MA40583A MA 40583 A MA40583 A MA 40583A MA 040583 A MA040583 A MA 040583A MA 40583 A MA40583 A MA 40583A MA 40583 A MA40583 A MA 40583A
- Authority
- MA
- Morocco
- Prior art keywords
- guanylate cyclase
- soluble guanylate
- cyclase activators
- novel soluble
- activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
L'invention concerne des activateurs de la guanylate cyclase soluble, de formule générique (i), et leur utilisation dans des compositions pharmaceutiques, principalement des compositions ophtalmiques administrées par voie topique. Les compositions pharmaceutiques sont utilisables pour réduire la pression intra-oculaire chez les animaux d'espèces de mammifères.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462052537P | 2014-09-19 | 2014-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA40583A true MA40583A (fr) | 2016-03-24 |
Family
ID=54238488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA040583A MA40583A (fr) | 2014-09-19 | 2015-09-18 | Nouveaux activateurs de la guanylate cyclase soluble et leur utilisation |
Country Status (21)
Country | Link |
---|---|
US (2) | US9938260B2 (fr) |
EP (1) | EP3194384A1 (fr) |
JP (3) | JP6678656B2 (fr) |
KR (1) | KR20170054508A (fr) |
CN (1) | CN106687456B (fr) |
AU (1) | AU2015319724B2 (fr) |
BR (1) | BR112017005660A2 (fr) |
CA (1) | CA2961745A1 (fr) |
CL (1) | CL2017000640A1 (fr) |
CO (1) | CO2017002506A2 (fr) |
CR (1) | CR20170102A (fr) |
DO (1) | DOP2017000073A (fr) |
EA (1) | EA033697B1 (fr) |
IL (1) | IL251094A0 (fr) |
MA (1) | MA40583A (fr) |
MX (1) | MX2017003621A (fr) |
PE (1) | PE20170937A1 (fr) |
PH (1) | PH12017500481A1 (fr) |
SG (1) | SG11201701915TA (fr) |
WO (1) | WO2016042536A1 (fr) |
ZA (1) | ZA201701835B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3102568T (lt) | 2014-02-06 | 2018-11-12 | Heptares Therapeutics Limited | Bicikliniai azo junginiai, kaip muskarino m1 receptorių agonistai |
AU2015319724B2 (en) * | 2014-09-19 | 2018-05-10 | Glaxosmithkline Intellectual Property Development Limited | Novel soluble guanylate cyclase activators and their use |
CU20170029A7 (es) | 2014-09-19 | 2017-08-08 | Bayer Pharma AG | Indazoles sustituidos con bencilo en calidad de inhibidores de bub1, útiles para el tratamiento o profilaxis de una enfermedad hiperproliferativa y/o un trastorno que responde a la inducción de la muerte celular, un procedimiento para la preparación de estos compuestos, y compuestos intermediarios |
CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
WO2019081456A1 (fr) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | Utilisation d'activateurs et de stimulateurs de sgc comprenant une sous-unité bêta2 |
EP3498298A1 (fr) | 2017-12-15 | 2019-06-19 | Bayer AG | Utilisation de stimulateurs sgc et d'activateurs sgc seuls ou en combinaison avec des inhibiteurs pde5 pour le traitement de troubles osseux, y compris l'ostéogénèse imparfaite (oi) |
CN112055584A (zh) | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
CN112384213A (zh) | 2018-05-15 | 2021-02-19 | 拜耳公司 | 用于治疗与神经纤维敏化有关的疾病的1,3-噻唑-2-基取代的苯甲酰胺 |
US11508483B2 (en) | 2018-05-30 | 2022-11-22 | Adverio Pharma Gmbh | Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group |
EP3911675A1 (fr) | 2019-01-17 | 2021-11-24 | Bayer Aktiengesellschaft | Procédés permettant de déterminer si un sujet est apte à être traité avec un agoniste de guanylyle cyclase soluble (sgc) |
WO2023237577A1 (fr) | 2022-06-09 | 2023-12-14 | Bayer Aktiengesellschaft | Activateurs de guanylate cyclase soluble destinés à être utilisés dans le traitement de l'insuffisance cardiaque à fraction d'éjection préservée chez les femmes |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602143A (en) | 1994-12-08 | 1997-02-11 | Allergan | Method for reducing intraocular pressure in the mammalian eye by administration of guanylate cyclase inhibitors |
ES2477993T3 (es) | 2006-11-09 | 2014-07-18 | Alcon Research, Ltd. | Matriz de polímero insoluble en agua para el suministro de fármaco |
WO2009071504A1 (fr) * | 2007-12-03 | 2009-06-11 | Smithkline Beecham Corporation | Pyridines 2,6-disubstituées comme activateurs de la guanylate cyclase soluble |
WO2010015653A1 (fr) * | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Dérivés de pyrimidine comme activateurs de guanylate cyclase soluble |
CA2753434C (fr) * | 2009-02-26 | 2014-07-15 | Merck Sharp & Dohme Corp. | Activateurs solubles de guanylate cyclase |
DE102009012314A1 (de) * | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
JP5636296B2 (ja) | 2011-01-20 | 2014-12-03 | 公益財団法人微生物化学研究会 | 塩分含有有機廃液処理剤、並びに、塩分濃度低下剤、塩分含有有機廃液の処理方法、及び包括固定担体 |
AU2015319724B2 (en) * | 2014-09-19 | 2018-05-10 | Glaxosmithkline Intellectual Property Development Limited | Novel soluble guanylate cyclase activators and their use |
-
2015
- 2015-09-18 AU AU2015319724A patent/AU2015319724B2/en active Active
- 2015-09-18 JP JP2017515074A patent/JP6678656B2/ja active Active
- 2015-09-18 CR CR20170102A patent/CR20170102A/es unknown
- 2015-09-18 MX MX2017003621A patent/MX2017003621A/es unknown
- 2015-09-18 KR KR1020177010181A patent/KR20170054508A/ko not_active Application Discontinuation
- 2015-09-18 PE PE2017000478A patent/PE20170937A1/es unknown
- 2015-09-18 EA EA201790655A patent/EA033697B1/ru not_active IP Right Cessation
- 2015-09-18 EP EP15772026.9A patent/EP3194384A1/fr not_active Withdrawn
- 2015-09-18 CN CN201580050717.XA patent/CN106687456B/zh active Active
- 2015-09-18 WO PCT/IB2015/057219 patent/WO2016042536A1/fr active Application Filing
- 2015-09-18 BR BR112017005660A patent/BR112017005660A2/pt not_active Application Discontinuation
- 2015-09-18 CA CA2961745A patent/CA2961745A1/fr not_active Abandoned
- 2015-09-18 SG SG11201701915TA patent/SG11201701915TA/en unknown
- 2015-09-18 MA MA040583A patent/MA40583A/fr unknown
- 2015-09-18 US US15/509,895 patent/US9938260B2/en active Active
-
2017
- 2017-03-12 IL IL251094A patent/IL251094A0/en unknown
- 2017-03-14 PH PH12017500481A patent/PH12017500481A1/en unknown
- 2017-03-14 ZA ZA2017/01835A patent/ZA201701835B/en unknown
- 2017-03-16 CO CONC2017/0002506A patent/CO2017002506A2/es unknown
- 2017-03-16 DO DO2017000073A patent/DOP2017000073A/es unknown
- 2017-03-16 CL CL2017000640A patent/CL2017000640A1/es unknown
-
2018
- 2018-03-05 US US15/911,797 patent/US10472350B2/en active Active
-
2020
- 2020-03-02 JP JP2020035272A patent/JP6908747B2/ja active Active
-
2021
- 2021-06-30 JP JP2021109106A patent/JP2021155450A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PE20170937A1 (es) | 2017-07-13 |
US10472350B2 (en) | 2019-11-12 |
CR20170102A (es) | 2017-07-17 |
US20180194756A1 (en) | 2018-07-12 |
EP3194384A1 (fr) | 2017-07-26 |
JP6908747B2 (ja) | 2021-07-28 |
JP2017527602A (ja) | 2017-09-21 |
WO2016042536A1 (fr) | 2016-03-24 |
AU2015319724A1 (en) | 2017-04-06 |
US9938260B2 (en) | 2018-04-10 |
PH12017500481A1 (en) | 2017-08-07 |
CL2017000640A1 (es) | 2017-10-06 |
CN106687456B (zh) | 2019-12-03 |
JP6678656B2 (ja) | 2020-04-08 |
CA2961745A1 (fr) | 2016-03-24 |
EA201790655A1 (ru) | 2017-08-31 |
EA033697B1 (ru) | 2019-11-18 |
DOP2017000073A (es) | 2017-04-16 |
SG11201701915TA (en) | 2017-04-27 |
AU2015319724B2 (en) | 2018-05-10 |
IL251094A0 (en) | 2017-04-30 |
ZA201701835B (en) | 2018-12-19 |
JP2021155450A (ja) | 2021-10-07 |
KR20170054508A (ko) | 2017-05-17 |
MX2017003621A (es) | 2017-07-14 |
CO2017002506A2 (es) | 2017-07-28 |
JP2020105189A (ja) | 2020-07-09 |
US20170305888A1 (en) | 2017-10-26 |
CN106687456A (zh) | 2017-05-17 |
BR112017005660A2 (pt) | 2017-12-19 |
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