MA39987A - Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées - Google Patents
Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associéesInfo
- Publication number
- MA39987A MA39987A MA039987A MA39987A MA39987A MA 39987 A MA39987 A MA 39987A MA 039987 A MA039987 A MA 039987A MA 39987 A MA39987 A MA 39987A MA 39987 A MA39987 A MA 39987A
- Authority
- MA
- Morocco
- Prior art keywords
- preparing
- processes
- new forms
- jak1 inhibitor
- inhibitor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
La présente invention concerne des procédés de préparation d'un inhibiteur de jak1 de formule ia, et des nouvelles formes de l'inhibiteur.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461986738P | 2014-04-30 | 2014-04-30 | |
US201461986789P | 2014-04-30 | 2014-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA39987A true MA39987A (fr) | 2017-03-08 |
Family
ID=53264736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA039987A MA39987A (fr) | 2014-04-30 | 2015-04-29 | Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées |
Country Status (20)
Country | Link |
---|---|
US (2) | US9802957B2 (fr) |
EP (1) | EP3137471A1 (fr) |
JP (1) | JP2017514832A (fr) |
KR (1) | KR20170007331A (fr) |
CN (1) | CN106687462A (fr) |
AU (1) | AU2015253192B2 (fr) |
BR (1) | BR112016025427A2 (fr) |
CA (1) | CA2947418A1 (fr) |
CL (3) | CL2016002748A1 (fr) |
CR (1) | CR20160553A (fr) |
EA (1) | EA201692193A1 (fr) |
EC (1) | ECSP16088985A (fr) |
IL (1) | IL248542B (fr) |
MA (1) | MA39987A (fr) |
MX (1) | MX2016014192A (fr) |
PE (1) | PE20170300A1 (fr) |
PH (1) | PH12016502177A1 (fr) |
SG (2) | SG10201809518QA (fr) |
TW (1) | TW201625643A (fr) |
WO (1) | WO2015168246A1 (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2343299T3 (en) | 2005-12-13 | 2016-01-18 | Incyte Holdings Corp | Heteroberl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
ES2575797T3 (es) | 2007-06-13 | 2016-07-01 | Incyte Holdings Corporation | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
DK2432472T3 (da) | 2009-05-22 | 2019-11-18 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- eller heptan-nitril som jak-inhibitorer |
MX364636B (es) | 2010-03-10 | 2019-05-03 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
EP3087972A1 (fr) | 2010-05-21 | 2016-11-02 | Incyte Holdings Corporation | Formulation topique pour un inhibiteur jak |
AU2011329734B2 (en) | 2010-11-19 | 2015-05-28 | Incyte Holdings Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
KR20140040819A (ko) | 2011-06-20 | 2014-04-03 | 인사이트 코포레이션 | Jak 저해제로서의 아제티디닐 페닐, 피리딜 또는 피라지닐 카르복스아미드 유도체 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
SG10201703533VA (en) | 2012-11-01 | 2017-06-29 | Incyte Corp | Tricyclic fused thiophene derivatives as jak inhibitors |
EP3949953A1 (fr) | 2012-11-15 | 2022-02-09 | Incyte Holdings Corporation | Formes posologiques à libération prolongée de ruxolitinibe |
CA2897200C (fr) | 2013-01-14 | 2021-07-06 | Incyte Corporation | Composes de carboxamide aromatique bicyclique utiles comme inhibiteurs de pim kinase |
MX2015009057A (es) | 2013-01-15 | 2015-10-05 | Incyte Corp | Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de cinasa pim. |
EP3489239B1 (fr) | 2013-03-06 | 2021-09-15 | Incyte Holdings Corporation | Procédés et intermédiaires pour fabriquer un inhibiteur de jak |
FI3786162T3 (fi) | 2013-05-17 | 2023-10-02 | Incyte Holdings Corp | Bipyratsolijohdannaisia jak-inhibiittoreina |
PT3030227T (pt) | 2013-08-07 | 2020-06-25 | Incyte Corp | Formas de dosagem de libertação prolongada para um inibidor de jak1 |
EA201690458A1 (ru) | 2013-08-23 | 2016-07-29 | Инсайт Корпорейшн | Фуро- и тиенопиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы |
EP3795152A1 (fr) | 2014-04-08 | 2021-03-24 | Incyte Corporation | Traitement d'affections malignes par lymphocytes b par un inhibiteur jak et pi3k combiné |
CA2947418A1 (fr) * | 2014-04-30 | 2015-11-05 | Incyte Corporation | Procedes de preparation d'un inhibiteur de jak1 et nouvelles formes associees |
WO2015184305A1 (fr) | 2014-05-30 | 2015-12-03 | Incyte Corporation | Traitement de la leucémie neutrophile chronique (cnl) et de la leucémie myéloïde chronique atypique (acml) par des inhibiteurs de jak1 |
US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
WO2017059251A1 (fr) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Composés hétérocycliques utiles en tant qu'inhibiteurs de la kinase pim |
WO2017223414A1 (fr) | 2016-06-24 | 2017-12-28 | Incyte Corporation | Composants hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-y |
WO2018067422A1 (fr) | 2016-10-03 | 2018-04-12 | Congxin Liang | Nouveaux inhibiteurs sélectifs de jak1 et leurs utilisations |
EP3568396B1 (fr) * | 2017-01-11 | 2020-11-11 | Leo Pharma A/S | Nouveaux dérivés d'amino-imidazopyridine en tant qu'inhibiteurs de janus kinase et leur utilisation pharmaceutique |
EP3641732A1 (fr) * | 2017-06-21 | 2020-04-29 | Minerva Neurosciences, Inc. | Formes posologiques orales gastro-résistantes à libération contrôlée |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
AR114810A1 (es) | 2018-01-30 | 2020-10-21 | Incyte Corp | Procesos e intermedios para elaborar un inhibidor de jak |
SG11202007805SA (en) | 2018-02-16 | 2020-09-29 | Incyte Corp | Jak1 pathway inhibitors for the treatment of cytokine-related disorders |
EP3775284A1 (fr) | 2018-03-30 | 2021-02-17 | Incyte Corporation | Biomarqueurs pour maladie cutanée inflammatoire |
MX2022012285A (es) | 2018-03-30 | 2023-08-15 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak). |
CN112567247A (zh) | 2018-04-13 | 2021-03-26 | 因赛特公司 | 用于移植物抗宿主病的生物标志物 |
CN113490484A (zh) | 2018-10-31 | 2021-10-08 | 因赛特公司 | 治疗血液疾病的组合疗法 |
EP3897627A1 (fr) | 2018-12-19 | 2021-10-27 | Incyte Corporation | Inhibiteurs de la voie jak1 pour le traitement d'une maladie gastro-intestinale |
WO2020181034A1 (fr) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Inhibiteurs de la voie jak1 pour le traitement d'un dysfonctionnement chronique de l'allogreffe pulmonaire |
EP3941474A2 (fr) | 2019-03-19 | 2022-01-26 | Incyte Corporation | Biomarqueurs pour le vitiligo |
AU2020287139A1 (en) * | 2019-06-06 | 2022-01-06 | Hangzhou Highlightll Pharmaceutical Co., Ltd. | Method for synthesizing furoimidazopyridine compound, polymorphic substance and polymorphic substance of salt |
CN113906035B (zh) * | 2019-06-06 | 2023-11-10 | 杭州高光制药有限公司 | 呋喃并咪唑并吡啶类化合物的合成方法、呋喃并咪唑并吡啶类化合物的晶型及其盐的晶型 |
US20210123931A1 (en) | 2019-10-10 | 2021-04-29 | Incyte Corporation | Biomarkers for graft-versus-host disease |
WO2021072116A1 (fr) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarqueurs de la maladie du greffon contre l'hôte |
WO2021076124A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Utilisation d'inhibiteurs de jak1 pour le traitement du lupus érythémateux cutané et du lichen plan (l.p.) |
AR122505A1 (es) | 2020-06-02 | 2022-09-14 | Incyte Corp | Procesos para preparar un inhibidor de jak1 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
KR20230095923A (ko) | 2020-08-18 | 2023-06-29 | 인사이트 코포레이션 | Jak1 억제제를 제조하기 위한 공정 및 중간체 |
EP4200300A1 (fr) | 2020-08-18 | 2023-06-28 | Incyte Corporation | Procédé et intermédiaires pour la préparation d'un inhibiteur de jak |
EP4255442A1 (fr) | 2020-12-04 | 2023-10-11 | Incyte Corporation | Inhibiteur de jak avec un analogue de la vitamine d pour le traitement de maladies de peau |
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US20240058343A1 (en) | 2022-08-05 | 2024-02-22 | Incyte Corporation | Treatment of urticaria using jak inhibitors |
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-
2015
- 2015-04-29 CA CA2947418A patent/CA2947418A1/fr not_active Abandoned
- 2015-04-29 JP JP2016565276A patent/JP2017514832A/ja active Pending
- 2015-04-29 MA MA039987A patent/MA39987A/fr unknown
- 2015-04-29 KR KR1020167033696A patent/KR20170007331A/ko unknown
- 2015-04-29 WO PCT/US2015/028224 patent/WO2015168246A1/fr active Application Filing
- 2015-04-29 TW TW104113773A patent/TW201625643A/zh unknown
- 2015-04-29 US US14/699,500 patent/US9802957B2/en active Active
- 2015-04-29 EP EP15724406.2A patent/EP3137471A1/fr not_active Withdrawn
- 2015-04-29 AU AU2015253192A patent/AU2015253192B2/en not_active Ceased
- 2015-04-29 CN CN201580034662.3A patent/CN106687462A/zh active Pending
- 2015-04-29 PE PE2016002151A patent/PE20170300A1/es unknown
- 2015-04-29 SG SG10201809518QA patent/SG10201809518QA/en unknown
- 2015-04-29 CR CR20160553A patent/CR20160553A/es unknown
- 2015-04-29 MX MX2016014192A patent/MX2016014192A/es unknown
- 2015-04-29 SG SG11201609016VA patent/SG11201609016VA/en unknown
- 2015-04-29 BR BR112016025427A patent/BR112016025427A2/pt not_active Application Discontinuation
- 2015-04-29 EA EA201692193A patent/EA201692193A1/ru unknown
-
2016
- 2016-10-27 IL IL248542A patent/IL248542B/en active IP Right Grant
- 2016-10-28 CL CL2016002748A patent/CL2016002748A1/es unknown
- 2016-11-02 PH PH12016502177A patent/PH12016502177A1/en unknown
- 2016-11-18 EC ECIEPI201688985A patent/ECSP16088985A/es unknown
-
2017
- 2017-09-22 US US15/712,850 patent/US10450325B2/en active Active
-
2018
- 2018-06-29 CL CL2018001790A patent/CL2018001790A1/es unknown
-
2019
- 2019-07-19 CL CL2019002032A patent/CL2019002032A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP16088985A (es) | 2017-02-24 |
CL2016002748A1 (es) | 2017-05-19 |
US9802957B2 (en) | 2017-10-31 |
MX2016014192A (es) | 2017-05-01 |
EP3137471A1 (fr) | 2017-03-08 |
JP2017514832A (ja) | 2017-06-08 |
BR112016025427A2 (pt) | 2017-08-15 |
CA2947418A1 (fr) | 2015-11-05 |
CL2018001790A1 (es) | 2018-08-31 |
KR20170007331A (ko) | 2017-01-18 |
AU2015253192A1 (en) | 2016-12-01 |
SG11201609016VA (en) | 2016-11-29 |
EA201692193A1 (ru) | 2017-07-31 |
CL2019002032A1 (es) | 2019-11-29 |
CR20160553A (es) | 2017-04-25 |
WO2015168246A1 (fr) | 2015-11-05 |
CN106687462A (zh) | 2017-05-17 |
US10450325B2 (en) | 2019-10-22 |
US20180099978A1 (en) | 2018-04-12 |
SG10201809518QA (en) | 2018-11-29 |
IL248542A0 (en) | 2016-12-29 |
AU2015253192B2 (en) | 2019-05-16 |
TW201625643A (zh) | 2016-07-16 |
US20150344497A1 (en) | 2015-12-03 |
PE20170300A1 (es) | 2017-04-19 |
IL248542B (en) | 2019-05-30 |
PH12016502177A1 (en) | 2017-02-06 |
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