MA39809B1 - Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih - Google Patents

Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih

Info

Publication number
MA39809B1
MA39809B1 MA39809A MA39809A MA39809B1 MA 39809 B1 MA39809 B1 MA 39809B1 MA 39809 A MA39809 A MA 39809A MA 39809 A MA39809 A MA 39809A MA 39809 B1 MA39809 B1 MA 39809B1
Authority
MA
Morocco
Prior art keywords
reverse transcriptase
substituted nucleoside
nucleoside derivatives
hiv reverse
transcriptase inhibitors
Prior art date
Application number
MA39809A
Other languages
English (en)
Other versions
MA39809A (fr
Inventor
Vinay Girijavallabhan
David Olsen
Zhibo Zhang
Bing-Yu Tang
Jianmin Fu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52824598&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA39809(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA39809A publication Critical patent/MA39809A/fr
Publication of MA39809B1 publication Critical patent/MA39809B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des dérivés nucléosidiques 4'-substitués de formule i (formule i) et leur utilisation pour l'inhibition de la transcriptase inverse du vih, la prévention d'une infection par le vih, le traitement d'une infection par le vih et la prévention, le traitement et le retardement de l'apparition ou de la progression du sida et/ou du complexe lié au sida.
MA39809A 2014-03-28 2015-03-26 Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih MA39809B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2014/074294 WO2015143712A1 (fr) 2014-03-28 2014-03-28 Inhibiteurs nucléosidiques substitués en 4' de la transcriptase inverse
PCT/US2015/022621 WO2015148746A1 (fr) 2014-03-28 2015-03-26 Dérivés nucléosidiques 4'-substitués utilisés comme inhibiteurs de la transcriptase inverse du vih

Publications (2)

Publication Number Publication Date
MA39809A MA39809A (fr) 2021-04-07
MA39809B1 true MA39809B1 (fr) 2021-10-29

Family

ID=52824598

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39809A MA39809B1 (fr) 2014-03-28 2015-03-26 Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih

Country Status (41)

Country Link
US (2) US9777035B2 (fr)
EP (1) EP3122752B1 (fr)
JP (1) JP6182680B2 (fr)
KR (1) KR101961009B1 (fr)
CN (1) CN106795199B (fr)
AP (1) AP2016009482A0 (fr)
AR (1) AR099788A1 (fr)
AU (2) AU2015236018B2 (fr)
CA (1) CA2943792C (fr)
CL (1) CL2016002414A1 (fr)
CR (1) CR20160451A (fr)
CY (1) CY1124829T1 (fr)
DK (1) DK3122752T3 (fr)
DO (1) DOP2016000265A (fr)
EA (1) EA031476B1 (fr)
EC (1) ECSP16085206A (fr)
ES (1) ES2894228T3 (fr)
GE (1) GEP20197009B (fr)
GT (1) GT201600201A (fr)
HR (1) HRP20211622T1 (fr)
HU (1) HUE056913T2 (fr)
IL (1) IL247923B (fr)
JO (1) JO3636B1 (fr)
LT (1) LT3122752T (fr)
MA (1) MA39809B1 (fr)
MD (1) MD4812C1 (fr)
MX (1) MX367058B (fr)
MY (1) MY194635A (fr)
NI (1) NI201600145A (fr)
NZ (1) NZ724343A (fr)
PE (1) PE20170197A1 (fr)
PH (1) PH12016501897A1 (fr)
PL (1) PL3122752T3 (fr)
PT (1) PT3122752T (fr)
RS (1) RS62418B1 (fr)
SG (1) SG11201608031PA (fr)
SI (1) SI3122752T1 (fr)
SV (1) SV2016005290A (fr)
TW (1) TWI660967B (fr)
UA (1) UA120758C2 (fr)
WO (2) WO2015143712A1 (fr)

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CR20160451A (es) 2016-12-06
AU2015236018A1 (en) 2016-10-06
HUE056913T2 (hu) 2022-03-28
NZ724343A (en) 2020-02-28
DK3122752T3 (da) 2021-10-25
PL3122752T3 (pl) 2022-01-03
CN106795199B (zh) 2020-01-10
SG11201608031PA (en) 2016-10-28
ECSP16085206A (es) 2017-08-31
MX367058B (es) 2019-08-02
GEP20197009B (en) 2019-08-12
RS62418B1 (sr) 2021-10-29
EP3122752A1 (fr) 2017-02-01
AP2016009482A0 (en) 2016-10-31
GT201600201A (es) 2018-12-18
MD4812B1 (ro) 2022-06-30
CA2943792A1 (fr) 2015-10-01
ES2894228T3 (es) 2022-02-14
DOP2016000265A (es) 2017-04-30
AR099788A1 (es) 2016-08-17
PT3122752T (pt) 2021-10-20
UA120758C2 (uk) 2020-02-10
MD4812C1 (ro) 2023-01-31
US20150274767A1 (en) 2015-10-01
IL247923A0 (en) 2016-11-30
AU2015236018B2 (en) 2017-09-28
JP2017512797A (ja) 2017-05-25
HRP20211622T1 (hr) 2022-03-04
MD20160117A2 (ro) 2017-02-28
KR20160128437A (ko) 2016-11-07
MA39809A (fr) 2021-04-07
US9777035B2 (en) 2017-10-03
NI201600145A (es) 2016-10-27
CY1124829T1 (el) 2022-11-25
BR112016022438A8 (pt) 2021-06-29
SI3122752T1 (sl) 2021-11-30
SV2016005290A (es) 2018-05-03
MX2016012659A (es) 2016-12-14
IL247923B (en) 2021-01-31
JP6182680B2 (ja) 2017-08-16
AU2017225090A1 (en) 2017-09-28
BR112016022438A2 (pt) 2017-08-15
AU2017225090B2 (en) 2018-08-09
CL2016002414A1 (es) 2017-05-05
EA201691931A1 (ru) 2017-02-28
WO2015148746A1 (fr) 2015-10-01
TW201619180A (zh) 2016-06-01
EP3122752B1 (fr) 2021-08-25
CN106795199A (zh) 2017-05-31
PH12016501897A1 (en) 2016-12-19
LT3122752T (lt) 2021-11-10
TWI660967B (zh) 2019-06-01
KR101961009B1 (ko) 2019-03-21
PE20170197A1 (es) 2017-03-22
EA031476B1 (ru) 2019-01-31
JO3636B1 (ar) 2020-08-27
MY194635A (en) 2022-12-08
CA2943792C (fr) 2020-02-25
WO2015143712A1 (fr) 2015-10-01
US20180002366A1 (en) 2018-01-04

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