DK3022174T3 - Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer - Google Patents

Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer Download PDF

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Publication number
DK3022174T3
DK3022174T3 DK14744725.4T DK14744725T DK3022174T3 DK 3022174 T3 DK3022174 T3 DK 3022174T3 DK 14744725 T DK14744725 T DK 14744725T DK 3022174 T3 DK3022174 T3 DK 3022174T3
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DK
Denmark
Prior art keywords
urine
derivatives
amino acids
substituted amino
receptor modulators
Prior art date
Application number
DK14744725.4T
Other languages
English (en)
Inventor
Richard L Beard
Tien T Duong
John E Donello
Michael E Garst
Veena Viswanath
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DK3022174T3 publication Critical patent/DK3022174T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043Leu-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
DK14744725.4T 2013-07-16 2014-07-10 Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer DK3022174T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361846787P 2013-07-16 2013-07-16
PCT/US2014/046203 WO2015009545A1 (en) 2013-07-16 2014-07-10 Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators

Publications (1)

Publication Number Publication Date
DK3022174T3 true DK3022174T3 (da) 2019-01-02

Family

ID=51230227

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14744725.4T DK3022174T3 (da) 2013-07-16 2014-07-10 Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer

Country Status (11)

Country Link
US (1) US9428549B2 (da)
EP (1) EP3022174B1 (da)
JP (1) JP6653253B2 (da)
KR (1) KR102313757B1 (da)
CN (1) CN105377814B (da)
AU (1) AU2014290618B2 (da)
CA (1) CA2917811C (da)
DK (1) DK3022174T3 (da)
ES (1) ES2708571T3 (da)
RU (1) RU2696581C2 (da)
WO (1) WO2015009545A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106518742B (zh) 2011-10-26 2020-01-21 阿勒根公司 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物
JP6196328B2 (ja) 2013-03-06 2017-09-13 アラーガン、インコーポレイテッドAllergan,Incorporated 皮膚疾患を治療するためのホルミルペプチド受容体2アゴニストの使用
KR102310615B1 (ko) 2013-11-21 2021-10-08 알러간, 인코포레이티드 페닐카바메이트 유도체로서의 포밀 펩타이드 수용체 조절제
WO2015079692A1 (ja) 2013-11-28 2015-06-04 杏林製薬株式会社 ウレア誘導体、またはその薬理学的に許容される塩
US9663457B2 (en) 2014-04-09 2017-05-30 Allergan, Inc. Carbamoyl hydrazine derivatives as formyl peptide modulators
RU2748652C2 (ru) 2014-05-21 2021-05-28 Аллерган, Инк. Производные имидазола как модуляторы формилпептидного рецептора
US10525058B2 (en) 2015-05-27 2020-01-07 Kyorin Pharmaceutical Co., Ltd Urea derivative or pharmacologically acceptable salt thereof
EP3303284B1 (en) 2015-05-27 2020-04-08 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
EP3331897B1 (en) * 2015-08-05 2021-03-24 Allergan, Inc. Phenyl urea analogs as formyl peptide receptor 1 (fpr1) selective agonists
PE20210046A1 (es) 2018-03-05 2021-01-08 Bristol Myers Squibb Co Agonistas de fenilpirrolidinona del receptor 2 de formil peptido

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533210A1 (fr) * 1982-09-17 1984-03-23 Lyon I Universite Claude Edulcorants de synthese
US5284828A (en) 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
JP3387948B2 (ja) * 1992-12-04 2003-03-17 富山化学工業株式会社 新規なフェニルアラニン誘導体またはその塩
US20030009022A1 (en) * 1993-03-31 2003-01-09 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
CN1145074A (zh) * 1994-02-09 1997-03-12 盐野义制药株式会社 氨基甲酰甲基脲衍生物
JP2968842B2 (ja) * 1994-02-09 1999-11-02 塩野義製薬株式会社 カルバモイルメチルウレア誘導体
US6423689B1 (en) * 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
AU4572999A (en) * 1998-06-18 2000-01-05 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
JP2005536187A (ja) * 2002-04-03 2005-12-02 バイエル・ヘルスケア・アクチェンゲゼルシャフト N−ホルミルペプチド受容体様1(fprl1)に関連する疾患の診断および治療
KR20060130064A (ko) * 2003-11-07 2006-12-18 아카디아 파마슈티칼스 인코포레이티드 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, fprl1의 용도
BRPI1013083A2 (pt) * 2009-05-18 2016-04-05 Actelion Pharmaceuticals Ltd derivados de espiro [2.4] heptano ligados como agonistas fprl2 e/ou recetor alx
WO2012074785A1 (en) * 2010-12-03 2012-06-07 Allergan, Inc. Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 h)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
CN106518742B (zh) * 2011-10-26 2020-01-21 阿勒根公司 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物
US8541577B2 (en) * 2011-11-10 2013-09-24 Allergan, Inc. Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators
US8735622B2 (en) * 2011-11-30 2014-05-27 The Regents Of The University Of Colorado, A Body Corporate Histone demethylase inhibitors and methods for using the same
JP6196328B2 (ja) * 2013-03-06 2017-09-13 アラーガン、インコーポレイテッドAllergan,Incorporated 皮膚疾患を治療するためのホルミルペプチド受容体2アゴニストの使用
JP6196327B2 (ja) * 2013-03-06 2017-09-13 アラーガン、インコーポレイテッドAllergan,Incorporated 眼炎症性疾患の治療のためのホルミルペプチド受容体2のアゴニストの使用

Also Published As

Publication number Publication date
AU2014290618A1 (en) 2016-02-18
JP6653253B2 (ja) 2020-02-26
RU2016104844A (ru) 2017-08-21
KR102313757B1 (ko) 2021-10-18
KR20160031007A (ko) 2016-03-21
US9428549B2 (en) 2016-08-30
US20150025021A1 (en) 2015-01-22
EP3022174B1 (en) 2018-09-05
AU2014290618B2 (en) 2018-04-05
ES2708571T3 (es) 2019-04-10
CA2917811C (en) 2021-08-31
CA2917811A1 (en) 2015-01-22
WO2015009545A1 (en) 2015-01-22
CN105377814A (zh) 2016-03-02
RU2696581C2 (ru) 2019-08-05
JP2016529235A (ja) 2016-09-23
CN105377814B (zh) 2018-04-03
EP3022174A1 (en) 2016-05-25

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