MA31093B1 - Vaccin - Google Patents
VaccinInfo
- Publication number
- MA31093B1 MA31093B1 MA32087A MA32087A MA31093B1 MA 31093 B1 MA31093 B1 MA 31093B1 MA 32087 A MA32087 A MA 32087A MA 32087 A MA32087 A MA 32087A MA 31093 B1 MA31093 B1 MA 31093B1
- Authority
- MA
- Morocco
- Prior art keywords
- fusion
- protein
- partner
- proteins
- antigen
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000004927 fusion Effects 0.000 abstract 2
- 241000606768 Haemophilus influenzae Species 0.000 abstract 1
- 102000036673 PRAME Human genes 0.000 abstract 1
- 108060006580 PRAME Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 229940047650 haemophilus influenzae Drugs 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001189—PRAME
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES PROTÉINES DE FUSION COMPRENANT UN ANTIGÈNE DÉRIVÉ DE L'ANTIGÈNE DIT DE REJET DES TUMEURS PRAME (ÉGALEMENT NOMMÉ DAGE) LIÉ À UN PARTENAIRE DE FUSION IMMUNOLOGIQUE QUI FOURNIT DES ÉPITOPES DE LYMPHOCYTES T AUXILIAIRES, TELS QUE, PAR EXEMPLE, LA PROTÉINE D DE HAEMOPHILUS INFLUENZAE B, DES PROTÉINES PARTENAIRES DE FUSION COMPRENANT DES FRAGMENTS DE LA PROTÉINE D, DES PROCÉDÉS POUR LEUR PRÉPARATION ET LA FORMULATION DE VACCINS AINSI QUE LEUR UTILISATION DANS LE TRAITEMENT DE TOUT UN ÉVENTAIL DE CANCERS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0700760A GB0700760D0 (en) | 2007-01-15 | 2007-01-15 | Vaccine |
GB0701262A GB0701262D0 (en) | 2007-01-23 | 2007-01-23 | Vaccine |
PCT/EP2008/050290 WO2008087102A1 (fr) | 2007-01-15 | 2008-01-11 | Vaccin |
Publications (1)
Publication Number | Publication Date |
---|---|
MA31093B1 true MA31093B1 (fr) | 2010-01-04 |
Family
ID=39300029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA32087A MA31093B1 (fr) | 2007-01-15 | 2009-07-10 | Vaccin |
Country Status (32)
Country | Link |
---|---|
US (1) | US20080187535A1 (fr) |
EP (1) | EP2114993B1 (fr) |
JP (1) | JP5391080B2 (fr) |
KR (1) | KR20090101313A (fr) |
CN (1) | CN101668770B (fr) |
AR (1) | AR064862A1 (fr) |
AU (1) | AU2008207025B2 (fr) |
BR (1) | BRPI0806463A2 (fr) |
CA (1) | CA2674552A1 (fr) |
CL (1) | CL2008000104A1 (fr) |
CO (1) | CO6210757A2 (fr) |
CR (1) | CR10971A (fr) |
CY (1) | CY1113760T1 (fr) |
DK (1) | DK2114993T3 (fr) |
DO (1) | DOP2009000167A (fr) |
EA (1) | EA016326B1 (fr) |
ES (1) | ES2393812T3 (fr) |
HK (1) | HK1138853A1 (fr) |
HR (1) | HRP20120828T1 (fr) |
IL (1) | IL199663A0 (fr) |
JO (1) | JO2840B1 (fr) |
MA (1) | MA31093B1 (fr) |
MX (1) | MX2009007571A (fr) |
MY (1) | MY153679A (fr) |
NZ (1) | NZ578285A (fr) |
PE (2) | PE20130324A1 (fr) |
PL (1) | PL2114993T3 (fr) |
PT (1) | PT2114993E (fr) |
SI (1) | SI2114993T1 (fr) |
TW (1) | TWI434697B (fr) |
WO (1) | WO2008087102A1 (fr) |
ZA (1) | ZA200904923B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0806501A2 (pt) * | 2007-01-15 | 2014-04-22 | Glaxosmithkline Biolog Sa | Proteína de fusão, molécula de ácido nucleico, vetor, célula hospedeira, vacina ou composição imunogênica, e, uso da proteína de fusão. |
MX2011009597A (es) | 2009-03-17 | 2012-05-29 | Glaxosmithkline Biolog Sa | Deteccion mejorada de la expresion del gen. |
JP2012529269A (ja) * | 2009-06-05 | 2012-11-22 | ジ オハイオ ステイト ユニヴァーシティ リサーチ ファウンデーション | 生体材料、組成物及び方法 |
GB0910046D0 (en) | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
GB201008682D0 (en) * | 2010-05-25 | 2010-07-07 | Vib Vzw | Epitope tag for affinity based applications |
GB201101331D0 (en) * | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
JP2014529338A (ja) * | 2011-07-22 | 2014-11-06 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Prameの精製 |
GB201114919D0 (en) * | 2011-08-30 | 2011-10-12 | Glaxosmithkline Biolog Sa | Method |
GB201116248D0 (en) | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
RU2590701C2 (ru) * | 2013-04-29 | 2016-07-10 | Общество с ограниченной ответственностью "ГеноТехнология" | Антигенная композиция и ее терапевтическое применение для профилактики и лечения онкологических заболеваний, рекомбинантная плазмидная днк, обеспечивающая синтез гибридного белка, а также способ получения белка |
EP3053592A4 (fr) | 2013-10-01 | 2017-09-06 | Mie University | Vaccin d'induction de lymphocytes t contenant une séquence interépitope favorisant une présentation d'antigène |
CN105254767A (zh) * | 2015-11-17 | 2016-01-20 | 重庆科润生物医药研发有限公司 | 一种Protein D与HER2融合蛋白及其制备方法和应用 |
SG10202105561PA (en) | 2016-11-30 | 2021-07-29 | Advaxis Inc | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
CN108264550B (zh) * | 2017-01-04 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别源自于prame抗原短肽的tcr |
CN108948184B (zh) * | 2017-05-22 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别衍生自prame抗原短肽的t细胞受体 |
CN109400697B (zh) * | 2017-08-17 | 2021-04-23 | 香雪生命科学技术(广东)有限公司 | 一种识别prame抗原短肽的tcr及其相关组合物 |
WO2019061297A1 (fr) * | 2017-09-29 | 2019-04-04 | 苏州工业园区唯可达生物科技有限公司 | Peptide de fusion d'épitope de lymphocyte t auxiliaire cd4 et vaccin associé |
US20210177955A1 (en) * | 2017-11-08 | 2021-06-17 | Advaxis, Inc. | Immunogenic heteroclitic peptides from cancer-associated proteins and methods of use thereof |
CN109879957B (zh) * | 2017-12-06 | 2022-03-18 | 香雪生命科学技术(广东)有限公司 | 针对prame的高亲和力t细胞受体 |
US20230190902A1 (en) * | 2020-05-29 | 2023-06-22 | Children's National Medical Center | Identification of hla-restricted prame peptide epitopes, prame-specific t cells suitable for "off-the-shelf" treatment of cancer expressing prame |
JP2024518378A (ja) | 2021-05-05 | 2024-05-01 | イマティクス バイオテクノロジーズ ゲーエムベーハー | Prameに特異的に結合する抗原結合タンパク質 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE466259B (sv) * | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
CA2156718A1 (fr) * | 1993-12-23 | 1995-06-29 | Bruno Gander | Procede de dynamisation de la reponse immunologique |
US5830753A (en) * | 1994-09-30 | 1998-11-03 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof. |
GB9717953D0 (en) * | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
SI1659178T1 (sl) * | 1998-02-05 | 2010-07-30 | Glaxosmithkline Biolog Sa | Postopek za čiščenje ali proizvodnjo MAGE proteina |
EP1156825A2 (fr) * | 1999-02-25 | 2001-11-28 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Immunogenes comprenant un peptide et support derive de haemophilius influenzae |
DE60023300T2 (de) * | 1999-06-29 | 2006-07-06 | Glaxosmithkline Biologicals S.A. | Verwendung von cpg als adjuvans für hivimpstoff |
EP1196772A2 (fr) * | 1999-07-08 | 2002-04-17 | Stressgen Biotechnologies Corporation | Stimulation d'une reponse de type th-1 in vitro |
-
2008
- 2008-01-11 CA CA002674552A patent/CA2674552A1/fr not_active Abandoned
- 2008-01-11 SI SI200830787T patent/SI2114993T1/sl unknown
- 2008-01-11 TW TW097101177A patent/TWI434697B/zh not_active IP Right Cessation
- 2008-01-11 PE PE2012001372A patent/PE20130324A1/es not_active Application Discontinuation
- 2008-01-11 PL PL08701434T patent/PL2114993T3/pl unknown
- 2008-01-11 PT PT08701434T patent/PT2114993E/pt unknown
- 2008-01-11 EA EA200900795A patent/EA016326B1/ru not_active IP Right Cessation
- 2008-01-11 KR KR1020097017027A patent/KR20090101313A/ko not_active Application Discontinuation
- 2008-01-11 DK DK08701434.6T patent/DK2114993T3/da active
- 2008-01-11 JP JP2009545186A patent/JP5391080B2/ja not_active Expired - Fee Related
- 2008-01-11 AR ARP080100127A patent/AR064862A1/es active IP Right Grant
- 2008-01-11 WO PCT/EP2008/050290 patent/WO2008087102A1/fr active Application Filing
- 2008-01-11 CN CN2008800078884A patent/CN101668770B/zh not_active Expired - Fee Related
- 2008-01-11 BR BRPI0806463-6A patent/BRPI0806463A2/pt not_active IP Right Cessation
- 2008-01-11 AU AU2008207025A patent/AU2008207025B2/en not_active Ceased
- 2008-01-11 MY MYPI20092932A patent/MY153679A/en unknown
- 2008-01-11 ES ES08701434T patent/ES2393812T3/es active Active
- 2008-01-11 MX MX2009007571A patent/MX2009007571A/es active IP Right Grant
- 2008-01-11 US US12/013,011 patent/US20080187535A1/en not_active Abandoned
- 2008-01-11 PE PE2008000124A patent/PE20081686A1/es not_active Application Discontinuation
- 2008-01-11 EP EP08701434A patent/EP2114993B1/fr not_active Not-in-force
- 2008-01-11 NZ NZ578285A patent/NZ578285A/en not_active IP Right Cessation
- 2008-01-13 JO JO200815A patent/JO2840B1/en active
- 2008-01-14 CL CL200800104A patent/CL2008000104A1/es unknown
-
2009
- 2009-07-02 DO DO2009000167A patent/DOP2009000167A/es unknown
- 2009-07-02 IL IL199663A patent/IL199663A0/en unknown
- 2009-07-10 MA MA32087A patent/MA31093B1/fr unknown
- 2009-07-14 ZA ZA2009/04923A patent/ZA200904923B/en unknown
- 2009-07-15 CO CO09073705A patent/CO6210757A2/es not_active Application Discontinuation
- 2009-08-07 CR CR10971A patent/CR10971A/es unknown
-
2010
- 2010-05-03 HK HK10104329.2A patent/HK1138853A1/xx not_active IP Right Cessation
-
2012
- 2012-10-15 HR HRP20120828AT patent/HRP20120828T1/hr unknown
- 2012-11-09 CY CY20121101065T patent/CY1113760T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA31093B1 (fr) | Vaccin | |
Rivoltini et al. | Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma-and colon carcinoma-specific T cells | |
Scally et al. | A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis | |
Hoffmann et al. | Frequencies of tetramer+ T cells specific for the wild-type sequence p53264–272 peptide in the circulation of patients with head and neck cancer | |
Chapman et al. | Induction of antibodies against GM2 ganglioside by immunizing melanoma patients using GM2-keyhole limpet hemocyanin+ QS21 vaccine: a dose-response study | |
Shams et al. | Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles | |
MA43458A1 (fr) | Nouveaux peptides, combinaisons de peptides et supports pour utilisation dans le traitementimmunothérapeutique de divers cancers | |
MA44693B1 (fr) | Peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer du sein et d'autres cancers | |
Perez et al. | Results from a phase I clinical study of the novel Ii-Key/HER-2/neu (776–790) hybrid peptide vaccine in patients with prostate cancer | |
Wald et al. | Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons | |
MA43328B2 (fr) | Lymphocytes t transfectés et récepteurs de lymphocytes t destinés à être utilisés en immunothérapie contre des cancers | |
Udono et al. | Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70 | |
Smith et al. | Vaccines targeting the cancer-testis antigen SSX-2 elicit HLA-A2 epitope-specific cytolytic T cells | |
Hoffmann et al. | The ability of variant peptides to reverse the nonresponsiveness of T lymphocytes to the wild-type sequence p53264–272 epitope | |
KR20180006945A (ko) | 암 치료 및 예방용 백신 | |
MA46506A1 (fr) | Nouveaux épitopes de cellules et nouvelle combinaison d'épitopes de cellules destinés à être utilisés dans l'immunothérapie du myélome et d'autres cancers | |
MA42045B1 (fr) | Nouveaux peptides et combinaisons de peptides et échafaudages formés de ceux-ci destinés à être utilisés en immunothérapie contre le carcinome colorectal (crc) et d'autres cancers | |
WO2016176624A3 (fr) | Pestivirus porcin, vaccins et dosages | |
Zwaveling et al. | Antitumor efficacy of wild-type p53-specific CD4+ T-helper cells | |
MA43794A (fr) | Procédés de prédiction de l'utilité de néoantigènes pour l'immunothérapie | |
IT8948458A1 (it) | Procedimento per la preparazione di vaccini capaci di generare non solo la risposta immune dei linfociti t helper, ma anche un'efficace risposta di linfociti t citotossici, e vaccini con queste caratteristiche | |
Kovjazin et al. | The use of signal peptide domains as vaccine candidates | |
Kalambokis et al. | Multiple myeloma presenting with an acute bacterial infection | |
Wong et al. | Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma | |
He et al. | Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model |