MA26754A1 - Composes morpholiniques antagonistes du recepteur de la nk-1. - Google Patents

Composes morpholiniques antagonistes du recepteur de la nk-1.

Info

Publication number
MA26754A1
MA26754A1 MA26111A MA26111A MA26754A1 MA 26754 A1 MA26754 A1 MA 26754A1 MA 26111 A MA26111 A MA 26111A MA 26111 A MA26111 A MA 26111A MA 26754 A1 MA26754 A1 MA 26754A1
Authority
MA
Morocco
Prior art keywords
morpholinic
compounds
receptor antagonist
receptor
compound
Prior art date
Application number
MA26111A
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26754A1 publication Critical patent/MA26754A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

COMPOSÉS MORPHOLINIQUES ANTAGONISTES DU RÉCEPTEUR DE LA NK-1 F. Hoffmann-La Roche AG L'invention a trait à un composé de formule : qui est le 2-(3,5-bis-trifluorométhylphényl)-N-méthyl-N-(6-morpholin-4-yl-4-o-tolylpyridin-3-yl)-isobutyramide. On a trouvé que le composé a une affinité pour le récepteur de la NK-1 et en outre, il est utile dans le traitement de maladies ayant un rapport avec ce récepteur.
MA26111A 1999-11-29 2000-11-28 Composes morpholiniques antagonistes du recepteur de la nk-1. MA26754A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
MA26754A1 true MA26754A1 (fr) 2004-12-20

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26111A MA26754A1 (fr) 1999-11-29 2000-11-28 Composes morpholiniques antagonistes du recepteur de la nk-1.

Country Status (50)

Country Link
EP (1) EP1103545B1 (fr)
JP (1) JP3480835B2 (fr)
KR (1) KR100390117B1 (fr)
CN (1) CN1152016C (fr)
AR (1) AR033659A1 (fr)
AT (1) ATE253561T1 (fr)
AU (1) AU775292B2 (fr)
BG (1) BG64622B1 (fr)
BR (1) BRPI0005616B8 (fr)
CA (1) CA2326529C (fr)
CO (1) CO5251405A1 (fr)
CZ (1) CZ299286B6 (fr)
DE (2) DE60006340T2 (fr)
DK (1) DK1103545T3 (fr)
DO (1) DOP2000000106A (fr)
EA (1) EA004404B1 (fr)
ES (2) ES2208205T3 (fr)
FR (1) FR2801590A1 (fr)
GB (1) GB2356863A (fr)
GC (1) GC0000151A (fr)
GE (1) GEP20022763B (fr)
GT (1) GT200000197A (fr)
HK (1) HK1036759A1 (fr)
HR (1) HRP20000809A2 (fr)
HU (1) HU224703B1 (fr)
ID (1) ID28483A (fr)
IL (1) IL139868A (fr)
IS (1) IS2212B (fr)
IT (1) IT1320120B1 (fr)
JO (1) JO2298B1 (fr)
MA (1) MA26754A1 (fr)
MX (1) MXPA00011672A (fr)
MY (1) MY127426A (fr)
NO (1) NO317264B1 (fr)
NZ (1) NZ508386A (fr)
OA (1) OA11513A (fr)
PA (1) PA8507201A1 (fr)
PE (1) PE20010901A1 (fr)
PL (1) PL195957B1 (fr)
PT (1) PT1103545E (fr)
SG (1) SG97171A1 (fr)
SI (1) SI1103545T1 (fr)
SK (1) SK285373B6 (fr)
SV (1) SV2002000227A (fr)
TN (1) TNSN00226A1 (fr)
TR (1) TR200302077T4 (fr)
UA (1) UA70326C2 (fr)
UY (1) UY26458A1 (fr)
YU (1) YU73400A (fr)
ZA (1) ZA200006964B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1157006B1 (fr) 1999-02-24 2006-10-25 F. Hoffmann-La Roche Ag Derives de pyridinyle et de phenyle utiles comme antagonistes de neurokinine-1
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
IL153834A0 (en) * 2000-07-14 2003-07-31 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
CN1625603A (zh) * 2002-01-31 2005-06-08 弗·哈夫曼-拉罗切有限公司 前速激肽原基因中的遗传多态性
RU2347777C2 (ru) 2003-07-03 2009-02-27 Ф.Хоффманн-Ля Рош Аг Двойные агонисты nk1/nk3 для лечения шизофрении
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
WO2006002860A1 (fr) 2004-07-06 2006-01-12 F. Hoffmann-La Roche Ag Procede pour la preparation de derives pyridines carboxamide utilises comme intermediaires dans la synthese d'antagonistes de recepteurs nk-1
EP2281556A1 (fr) 2005-02-25 2011-02-09 F. Hoffmann-La Roche AG Comprimés avec une meilleure dispersibilité de substance des médicaments
CA2602445C (fr) * 2005-03-23 2013-08-20 F.Hoffmann-La Roche Ag Metabolites pour les antagonistes nk-i contre le vomissement
ES2335922T3 (es) 2005-09-23 2010-04-06 F.Hoffmann-La Roche Ag Nueva formulacion de dosificacion.
WO2008090117A1 (fr) 2007-01-24 2008-07-31 Glaxo Group Limited Nouvelles compositions pharmaceutiques
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
WO2014150276A1 (fr) 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Composés et leurs utilisations pour la modulation de l'hémoglobine
CA2930008A1 (fr) 2013-11-08 2015-05-14 Kissei Pharmaceutical Co., Ltd. Derive de carboxymethylpiperidine
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533280B2 (fr) * 1991-09-20 2004-12-01 Glaxo Group Limited Nouvelle indication médicale pour les antagonistes des tachykinines
CA2099233A1 (fr) * 1992-06-29 1993-12-30 Conrad P. Dorn Antagonistes du recepteur de la tachykinine a base de morpholine et de thiomorpholine
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
DK0737192T3 (da) * 1993-12-29 2001-11-26 Merck Sharp & Dohme Substituerede morpholinderivater og deres anvendelse som terapeutiske midler
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
ES2194937T3 (es) * 1995-03-24 2003-12-01 Takeda Chemical Industries Ltd Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina.
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
IL153834A0 (en) * 2000-07-14 2003-07-31 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
DK1103545T3 (da) 2004-03-15
JP2001151754A (ja) 2001-06-05
UA70326C2 (en) 2004-10-15
YU73400A (sh) 2003-02-28
EA200001114A3 (ru) 2001-12-24
PA8507201A1 (es) 2002-02-21
HUP0004725A2 (hu) 2002-04-29
PE20010901A1 (es) 2001-09-20
HRP20000809A2 (en) 2001-12-31
EA004404B1 (ru) 2004-04-29
ITMI20002575A1 (it) 2002-05-29
IS2212B (is) 2007-02-15
CN1152016C (zh) 2004-06-02
SK285373B6 (sk) 2006-12-07
CZ20004399A3 (cs) 2001-07-11
NZ508386A (en) 2003-02-28
SI1103545T1 (en) 2004-02-29
BRPI0005616B8 (pt) 2021-07-06
CA2326529A1 (fr) 2001-05-29
JO2298B1 (en) 2005-09-12
AU775292B2 (en) 2004-07-29
DE10058310A1 (de) 2001-05-31
SK17932000A3 (sk) 2001-11-06
AU7178700A (en) 2001-05-31
GB2356863A (en) 2001-06-06
GB0028566D0 (en) 2001-01-10
FR2801590A1 (fr) 2001-06-01
GEP20022763B (en) 2002-08-26
SV2002000227A (es) 2002-02-05
HU0004725D0 (fr) 2001-02-28
ID28483A (id) 2001-05-31
MY127426A (en) 2006-11-30
PL195957B1 (pl) 2007-11-30
DOP2000000106A (es) 2002-07-30
EP1103545B1 (fr) 2003-11-05
EP1103545A1 (fr) 2001-05-30
NO317264B1 (no) 2004-09-27
CZ299286B6 (cs) 2008-06-04
NO20006012L (no) 2001-05-30
ES2208205T3 (es) 2004-06-16
NO20006012D0 (no) 2000-11-28
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
IT1320120B1 (it) 2003-11-18
IL139868A (en) 2009-09-01
BG104992A (en) 2001-11-30
UY26458A1 (es) 2001-05-31
GT200000197A (es) 2002-05-22
MXPA00011672A (es) 2002-08-20
ATE253561T1 (de) 2003-11-15
AR033659A1 (es) 2004-01-07
KR100390117B1 (ko) 2003-07-04
DE60006340D1 (de) 2003-12-11
BR0005616A (pt) 2001-07-17
PL344147A1 (en) 2001-06-04
CA2326529C (fr) 2009-12-22
TNSN00226A1 (fr) 2002-05-30
IL139868A0 (en) 2002-02-10
BG64622B1 (bg) 2005-09-30
HU224703B1 (en) 2006-01-30
SG97171A1 (en) 2003-07-18
EA200001114A2 (ru) 2001-08-27
ES2171134A1 (es) 2002-08-16
HK1036759A1 (en) 2002-01-18
KR20010051983A (ko) 2001-06-25
CO5251405A1 (es) 2003-02-28
TR200302077T4 (tr) 2004-01-21
PT1103545E (pt) 2004-03-31
IS5725A (is) 2001-05-29
ZA200006964B (en) 2001-06-05
CN1297888A (zh) 2001-06-06
BRPI0005616B1 (pt) 2017-12-12
JP3480835B2 (ja) 2003-12-22
OA11513A (fr) 2004-02-03

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