AR033659A1 - El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene - Google Patents

El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene

Info

Publication number
AR033659A1
AR033659A1 ARP000106217A ARP000106217A AR033659A1 AR 033659 A1 AR033659 A1 AR 033659A1 AR P000106217 A ARP000106217 A AR P000106217A AR P000106217 A ARP000106217 A AR P000106217A AR 033659 A1 AR033659 A1 AR 033659A1
Authority
AR
Argentina
Prior art keywords
compound
bis
phenyl
prepare
methyl
Prior art date
Application number
ARP000106217A
Other languages
English (en)
Inventor
Theresa Maria Ballard
Guy Andrew Higgins
Torsten Hoffmann
Sonia Maria Poli
Andrew Sleight
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR033659A1 publication Critical patent/AR033659A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

El compuesto 2-(3,5-bis-trifluorometil-fenil)-N-metil-N-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida de fórmula (1) y sus sales de adición de ácido farmacéuticamente aceptables; su uso; un procedimiento para prepararlo; y un medicamento que lo contiene. Se ha encontrado que este compuesto tiene una alta afinidad al receptor NK-1 y es por tanto útil en el tratamiento de enfermedades relacionadas con este receptor, tales como trastornos del sistema nervioso central, por ejemplo trastornos depresivos, ansiedad o emesis.
ARP000106217A 1999-11-29 2000-11-27 El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene AR033659A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99123685 1999-11-29

Publications (1)

Publication Number Publication Date
AR033659A1 true AR033659A1 (es) 2004-01-07

Family

ID=8239481

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106217A AR033659A1 (es) 1999-11-29 2000-11-27 El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene

Country Status (50)

Country Link
EP (1) EP1103545B1 (es)
JP (1) JP3480835B2 (es)
KR (1) KR100390117B1 (es)
CN (1) CN1152016C (es)
AR (1) AR033659A1 (es)
AT (1) ATE253561T1 (es)
AU (1) AU775292B2 (es)
BG (1) BG64622B1 (es)
BR (1) BRPI0005616B8 (es)
CA (1) CA2326529C (es)
CO (1) CO5251405A1 (es)
CZ (1) CZ299286B6 (es)
DE (2) DE60006340T2 (es)
DK (1) DK1103545T3 (es)
DO (1) DOP2000000106A (es)
EA (1) EA004404B1 (es)
ES (2) ES2208205T3 (es)
FR (1) FR2801590A1 (es)
GB (1) GB2356863A (es)
GC (1) GC0000151A (es)
GE (1) GEP20022763B (es)
GT (1) GT200000197A (es)
HK (1) HK1036759A1 (es)
HR (1) HRP20000809A2 (es)
HU (1) HU224703B1 (es)
ID (1) ID28483A (es)
IL (1) IL139868A (es)
IS (1) IS2212B (es)
IT (1) IT1320120B1 (es)
JO (1) JO2298B1 (es)
MA (1) MA26754A1 (es)
MX (1) MXPA00011672A (es)
MY (1) MY127426A (es)
NO (1) NO317264B1 (es)
NZ (1) NZ508386A (es)
OA (1) OA11513A (es)
PA (1) PA8507201A1 (es)
PE (1) PE20010901A1 (es)
PL (1) PL195957B1 (es)
PT (1) PT1103545E (es)
SG (1) SG97171A1 (es)
SI (1) SI1103545T1 (es)
SK (1) SK285373B6 (es)
SV (1) SV2002000227A (es)
TN (1) TNSN00226A1 (es)
TR (1) TR200302077T4 (es)
UA (1) UA70326C2 (es)
UY (1) UY26458A1 (es)
YU (1) YU73400A (es)
ZA (1) ZA200006964B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1157006B1 (en) 1999-02-24 2006-10-25 F. Hoffmann-La Roche Ag Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
IL153834A0 (en) * 2000-07-14 2003-07-31 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives
US20030083345A1 (en) * 2001-07-10 2003-05-01 Torsten Hoffmann Method of treatment and/or prevention of brain, spinal or nerve injury
CN1625603A (zh) * 2002-01-31 2005-06-08 弗·哈夫曼-拉罗切有限公司 前速激肽原基因中的遗传多态性
RU2347777C2 (ru) 2003-07-03 2009-02-27 Ф.Хоффманн-Ля Рош Аг Двойные агонисты nk1/nk3 для лечения шизофрении
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
WO2006002860A1 (en) 2004-07-06 2006-01-12 F. Hoffmann-La Roche Ag Process for preparing carboxamide pyridine derivatives used as intermediates in the synthesis of nk-1 receptor antagonists
EP2281556A1 (en) 2005-02-25 2011-02-09 F. Hoffmann-La Roche AG Tablets with improved drugs substance dispersibility
CA2602445C (en) * 2005-03-23 2013-08-20 F.Hoffmann-La Roche Ag Metabolites for nk-i antagonists for emesis
ES2335922T3 (es) 2005-09-23 2010-04-06 F.Hoffmann-La Roche Ag Nueva formulacion de dosificacion.
WO2008090117A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
WO2014150276A1 (en) 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CA2930008A1 (en) 2013-11-08 2015-05-14 Kissei Pharmaceutical Co., Ltd. Carboxymethyl piperidine derivative
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
KR101948238B1 (ko) 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533280B2 (en) * 1991-09-20 2004-12-01 Glaxo Group Limited Novel medical use for tachykinin antagonists
CA2099233A1 (en) * 1992-06-29 1993-12-30 Conrad P. Dorn Morpholine and thiomorpholine tachykinin receptor antagonists
IL111960A (en) * 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
DK0737192T3 (da) * 1993-12-29 2001-11-26 Merck Sharp & Dohme Substituerede morpholinderivater og deres anvendelse som terapeutiske midler
IL112778A0 (en) * 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
ES2194937T3 (es) * 1995-03-24 2003-12-01 Takeda Chemical Industries Ltd Compuestos ciclicos, su produccion y uso como antagonistas de los receptores de taquiquinina.
US5972938A (en) * 1997-12-01 1999-10-26 Merck & Co., Inc. Method for treating or preventing psychoimmunological disorders
DK1394150T3 (da) * 1999-02-24 2011-03-21 Hoffmann La Roche 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister
US6303790B1 (en) * 1999-11-29 2001-10-16 Hoffman-La Roche Inc. Process for the preparation of pyridine derivatives
IL153834A0 (en) * 2000-07-14 2003-07-31 Hoffmann La Roche N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives
TWI287003B (en) * 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
TWI259180B (en) * 2000-08-08 2006-08-01 Hoffmann La Roche 4-Phenyl-pyridine derivatives

Also Published As

Publication number Publication date
DK1103545T3 (da) 2004-03-15
JP2001151754A (ja) 2001-06-05
UA70326C2 (en) 2004-10-15
YU73400A (sh) 2003-02-28
EA200001114A3 (ru) 2001-12-24
PA8507201A1 (es) 2002-02-21
HUP0004725A2 (hu) 2002-04-29
PE20010901A1 (es) 2001-09-20
MA26754A1 (fr) 2004-12-20
HRP20000809A2 (en) 2001-12-31
EA004404B1 (ru) 2004-04-29
ITMI20002575A1 (it) 2002-05-29
IS2212B (is) 2007-02-15
CN1152016C (zh) 2004-06-02
SK285373B6 (sk) 2006-12-07
CZ20004399A3 (cs) 2001-07-11
NZ508386A (en) 2003-02-28
SI1103545T1 (en) 2004-02-29
BRPI0005616B8 (pt) 2021-07-06
CA2326529A1 (en) 2001-05-29
JO2298B1 (en) 2005-09-12
AU775292B2 (en) 2004-07-29
DE10058310A1 (de) 2001-05-31
SK17932000A3 (sk) 2001-11-06
AU7178700A (en) 2001-05-31
GB2356863A (en) 2001-06-06
GB0028566D0 (en) 2001-01-10
FR2801590A1 (fr) 2001-06-01
GEP20022763B (en) 2002-08-26
SV2002000227A (es) 2002-02-05
HU0004725D0 (es) 2001-02-28
ID28483A (id) 2001-05-31
MY127426A (en) 2006-11-30
PL195957B1 (pl) 2007-11-30
DOP2000000106A (es) 2002-07-30
EP1103545B1 (en) 2003-11-05
EP1103545A1 (en) 2001-05-30
NO317264B1 (no) 2004-09-27
CZ299286B6 (cs) 2008-06-04
NO20006012L (no) 2001-05-30
ES2208205T3 (es) 2004-06-16
NO20006012D0 (no) 2000-11-28
DE60006340T2 (de) 2004-09-09
GC0000151A (en) 2005-06-29
IT1320120B1 (it) 2003-11-18
IL139868A (en) 2009-09-01
BG104992A (en) 2001-11-30
UY26458A1 (es) 2001-05-31
GT200000197A (es) 2002-05-22
MXPA00011672A (es) 2002-08-20
ATE253561T1 (de) 2003-11-15
KR100390117B1 (ko) 2003-07-04
DE60006340D1 (de) 2003-12-11
BR0005616A (pt) 2001-07-17
PL344147A1 (en) 2001-06-04
CA2326529C (en) 2009-12-22
TNSN00226A1 (fr) 2002-05-30
IL139868A0 (en) 2002-02-10
BG64622B1 (bg) 2005-09-30
HU224703B1 (en) 2006-01-30
SG97171A1 (en) 2003-07-18
EA200001114A2 (ru) 2001-08-27
ES2171134A1 (es) 2002-08-16
HK1036759A1 (en) 2002-01-18
KR20010051983A (ko) 2001-06-25
CO5251405A1 (es) 2003-02-28
TR200302077T4 (tr) 2004-01-21
PT1103545E (pt) 2004-03-31
IS5725A (is) 2001-05-29
ZA200006964B (en) 2001-06-05
CN1297888A (zh) 2001-06-06
BRPI0005616B1 (pt) 2017-12-12
JP3480835B2 (ja) 2003-12-22
OA11513A (fr) 2004-02-03

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