LU84447A1 - Stabilisierte insulinpraeparate und verfahren zur herstellung derselben - Google Patents

Stabilisierte insulinpraeparate und verfahren zur herstellung derselben Download PDF

Info

Publication number
LU84447A1
LU84447A1 LU84447A LU84447A LU84447A1 LU 84447 A1 LU84447 A1 LU 84447A1 LU 84447 A LU84447 A LU 84447A LU 84447 A LU84447 A LU 84447A LU 84447 A1 LU84447 A1 LU 84447A1
Authority
LU
Luxembourg
Prior art keywords
insulin
solution according
insulin solution
solution
formula
Prior art date
Application number
LU84447A
Other languages
German (de)
English (en)
French (fr)
Inventor
Philip Edgar Hansen
Svend Havelund
Jens Jorgen Vejlgaard
Original Assignee
Novo Ind Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Ind Sa filed Critical Novo Ind Sa
Publication of LU84447A1 publication Critical patent/LU84447A1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
LU84447A 1981-10-30 1982-10-29 Stabilisierte insulinpraeparate und verfahren zur herstellung derselben LU84447A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK478681 1981-10-30
DK478681 1981-10-30
DK324782 1982-07-20
DK324782 1982-07-20

Publications (1)

Publication Number Publication Date
LU84447A1 true LU84447A1 (fr) 1983-06-13

Family

ID=26066963

Family Applications (1)

Application Number Title Priority Date Filing Date
LU84447A LU84447A1 (fr) 1981-10-30 1982-10-29 Stabilisierte insulinpraeparate und verfahren zur herstellung derselben

Country Status (20)

Country Link
US (1) US4614730A (sv)
AT (1) AT382079B (sv)
AU (1) AU549593B2 (sv)
BE (1) BE894885A (sv)
CA (1) CA1198673A (sv)
CH (1) CH649922A5 (sv)
DE (1) DE3240177A1 (sv)
ES (1) ES516963A0 (sv)
FI (1) FI80595C (sv)
FR (1) FR2515517B1 (sv)
GB (1) GB2107985B (sv)
GR (1) GR77360B (sv)
IE (1) IE54029B1 (sv)
IT (1) IT1153315B (sv)
LU (1) LU84447A1 (sv)
NL (1) NL193099C (sv)
NO (1) NO168086C (sv)
NZ (1) NZ202328A (sv)
PT (1) PT75766B (sv)
SE (1) SE460576B (sv)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
WO1985005029A1 (en) * 1984-05-09 1985-11-21 Medaphore Inc. Oral insulin and a method of making the same
DE3443877A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung
CA1257199A (en) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
FR2605449B1 (fr) * 1986-10-17 1988-12-02 Thomson Cgr Bloc magnetique a aimantation ajustable pour la production d'un champ magnetique permanent dans une zone d'interet
US5179079A (en) * 1986-12-16 1993-01-12 Novo Nordisk A/S Nasal formulation and intranasal administration therewith
NZ222907A (en) * 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
US5266310A (en) * 1987-09-17 1993-11-30 Boehringer Ingelheim International Gmbh Stabilization of therapeutically active proteins in pharmaceutical preparations
NO179479C (no) * 1988-03-11 1996-10-16 Teikoku Seiyaku Kk Fremgangsmåte for fremstilling av et intravaginalt farmasöytisk preparat
US5725871A (en) * 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
WO1991016453A1 (en) * 1990-04-17 1991-10-31 Analytical Control Systems, Inc. Coagulation assays and reagents
DE4208552A1 (de) * 1992-03-17 1993-09-23 Liedtke Pharmed Gmbh Topische arzneiformen mit insulin
PT748213E (pt) 1994-03-07 2004-08-31 Nektar Therapeutics Metodos e composicoes para administracao pulmonar de insulina
US6214375B1 (en) 1996-07-16 2001-04-10 Generex Pharmaceuticals, Inc. Phospholipid formulations
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6290987B1 (en) 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
US6271200B1 (en) 1998-12-21 2001-08-07 Generex Pharmaceuticals Inc. Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6436367B1 (en) 1998-12-21 2002-08-20 Generex Pharmaceuticals Inc. Aerosol formulations for buccal and pulmonary application
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
AU2003236201A1 (en) 2002-05-07 2003-11-11 Novo Nordisk A/S Soluble formulations comprising monomeric insulin and acylated insulin
US20040018237A1 (en) 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US8435942B2 (en) * 2002-05-31 2013-05-07 Transdermal Biotechnology, Inc. Methods for formulating stabilized insulin compositions
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US8911751B2 (en) * 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
AU2009226910B2 (en) 2008-03-18 2014-02-06 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
KR101939557B1 (ko) 2008-10-17 2019-01-17 사노피-아벤티스 도이칠란트 게엠베하 인슐린과 ｇｌｐ－1 효능제의 병용물
CN107308442B (zh) 2009-11-13 2022-10-18 赛诺菲-安万特德国有限公司 包含glp-1激动剂、胰岛素和甲硫氨酸的药物组合物
PT3345593T (pt) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
CN102573889B (zh) 2010-07-14 2014-10-22 中国医学科学院药物研究所 一种胰岛素的脂质复合物及其制备方法和制剂
LT2611458T (lt) 2010-08-30 2016-12-27 Sanofi-Aventis Deutschland Gmbh Ave0010 panaudojimas gaminant vaistą, skirtą 2 tipo cukrinio diabeto gydymui
JP2014508166A (ja) 2011-03-17 2014-04-03 トランスダーマル バイオテクノロジ インコーポレーテッド 局所的一酸化窒素システム及びその使用方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
MX370264B (es) 2011-08-29 2019-12-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2.
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
SI3229828T1 (sl) 2014-12-12 2023-06-30 Sanofi-Aventis Deutschland Gmbh Formulacija s fiksnim razmerjem inzulin glargin/liksisenatid
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
BR112019011761A2 (pt) 2016-12-16 2019-11-05 Novo Nordisk As composições farmacêuticas contendo insulina
WO2019016814A1 (en) 2017-07-20 2019-01-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. PHARMACEUTICAL FILM COMPOSITIONS FOR THE ADMINISTRATION OF LIPOPHILIC COMPOUNDS IN AND / OR THROUGH THE SKIN

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2563070A (en) * 1947-12-19 1951-08-07 Chicago Medical School Antidiabetic
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product
JPS50116028A (sv) * 1974-02-26 1975-09-11
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4164573A (en) * 1975-06-13 1979-08-14 Galinsky Alvin M Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
US4153689A (en) * 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
DE2652636A1 (de) * 1976-11-19 1978-05-24 Hans Uwe Dr Rer Nat Wolf Verfahren zur stabilisierung von proteinen und verwandten verbindungen waehrend ihrer reinigung, isolierung und lagerung
CH621479A5 (sv) * 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (sv) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
DE2952119A1 (de) * 1979-12-22 1981-07-09 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige protein-loesungen
EP0032622B1 (en) * 1979-12-20 1985-08-14 Dennis Chapman Polymerisable phospholipids and polymers thereof, methods for their preparation, methods for their use in coating substrates and forming liposomes and the resulting coated substrates and liposome compositions

Also Published As

Publication number Publication date
FR2515517B1 (fr) 1987-07-03
IE54029B1 (en) 1989-05-24
NO168086C (no) 1992-01-15
GB2107985A (en) 1983-05-11
NL193099C (nl) 1998-11-03
FI80595B (fi) 1990-03-30
IT8223990A0 (it) 1982-10-29
AT382079B (de) 1987-01-12
ES8403025A1 (es) 1984-03-01
NO823603L (no) 1983-05-02
FR2515517A1 (fr) 1983-05-06
GB2107985B (en) 1984-11-14
IT1153315B (it) 1987-01-14
FI823702A0 (fi) 1982-10-29
SE460576B (sv) 1989-10-30
FI823702L (fi) 1983-05-01
CA1198673A (en) 1985-12-31
FI80595C (sv) 1990-07-10
NL193099B (nl) 1998-07-01
SE8206168D0 (sv) 1982-10-29
IE822602L (en) 1983-04-30
GR77360B (sv) 1984-09-11
AU549593B2 (en) 1986-01-30
PT75766A (en) 1982-11-01
ATA392482A (de) 1986-06-15
NL8203944A (nl) 1983-05-16
AU8986182A (en) 1983-05-05
US4614730A (en) 1986-09-30
DE3240177A1 (de) 1983-05-11
SE8206168L (sv) 1983-05-01
ES516963A0 (es) 1984-03-01
NO168086B (no) 1991-10-07
PT75766B (en) 1985-12-09
DE3240177C2 (sv) 1993-07-22
NZ202328A (en) 1985-07-12
BE894885A (fr) 1983-04-29
CH649922A5 (de) 1985-06-28

Similar Documents

Publication Publication Date Title
LU84447A1 (fr) Stabilisierte insulinpraeparate und verfahren zur herstellung derselben
DE3303860C2 (sv)
EP0357978B1 (de) Pharmazeutische Zubereitung zur Behandlung des Diabetes mellitus
DE602005002495T2 (de) Injizierbare Formulierung mit Natriumdiclofenac, Beta-Cyclodextrin und einem Polysorbat
DE69734742T2 (de) Arzneizusammensetzungen enthaltend Ascomycinderivate
DE69834956T2 (de) Stabile Insulinformulierungen
DE69728783T2 (de) Verbesserte arzneimittel
DE69827357T2 (de) Menschliches Wachstumshormon enthaltende pharmazeutische Zusammensetzung
DE69829254T2 (de) Arzneistoffzubereitung mit kontrollierter Wirkstofffreisetzungsrate
DE2415101A1 (de) Pharmazeutische zusammensetzungen
DE60114249T2 (de) Pharmazeutische zusammensetzung mit 2-(4-isobutylphenyl) propionsäure
DE60116483T2 (de) Gelartige pharmazeutische zusammensetzung zur subcutanen anwendung enthaltend bisphosphonsäuren oder deren salze
EP1687031A1 (de) Pharmazeutische zubereitung enthaltend einen antikörper gegen den egf-rezeptor
EP1206244B1 (de) Wässrige arzneimittelformulierung von moxifloxacin oder salzen davon
EP0166971B1 (de) Insulinzubereitungen, Verfahren zu deren Herstellung und deren Verwendung
DE69831223T2 (de) Gefriergetrocknete zusammensetzung des menschlichen,morphogenen knochenproteins mp52
DE60101979T2 (de) Lösung enthaltend N-[O-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glyzin Mononatriumsalz Tetrahydrat und diese Lösung enthaltendes Arzneimittel
EP0187361A2 (de) Präparate mit verzögerter Wirkung, Verfahren zu deren Herstellung sowie entprechende Mittel zur Human- bzw. veterinärmedizinischen Anwendung
WO2000056325A2 (de) Ibuprofen-lösung
DE2546474A1 (de) Injizierbares pharmazeutisches thyroxinpraeparat und verfahren zu dessen herstellung
WO1993003745A1 (de) Verfahren zur herstellung von humanprotein-enthaltenden, gut verträglichen arzneimitteln für infusions- oder injektionszwecke
DE602004012731T2 (de) Zubereitungen mit verzögerter freigabe enthaltend zink, und herstellung derselben
DE60005188T2 (de) Grf-haltige lyophilisierte arzneizusammensetzungen
EP0656777B1 (de) Spritzfertige azosemid-injektionslösungen
WO2009128357A1 (ja) 生理活性蛋白質含有ナノ粒子組成物およびその製造方法