AT382079B - Verfahren zur herstellung einer stabilisierten waesserigen insulinloesung - Google Patents

Verfahren zur herstellung einer stabilisierten waesserigen insulinloesung

Info

Publication number
AT382079B
AT382079B AT0392482A AT392482A AT382079B AT 382079 B AT382079 B AT 382079B AT 0392482 A AT0392482 A AT 0392482A AT 392482 A AT392482 A AT 392482A AT 382079 B AT382079 B AT 382079B
Authority
AT
Austria
Prior art keywords
producing
insulin solution
stabilized aqueous
aqueous insulin
stabilized
Prior art date
Application number
AT0392482A
Other languages
English (en)
Other versions
ATA392482A (de
Inventor
Philip Edgar Hansen
Jens Jorgen Vejlgaard Brange
Svend Hawelung
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of ATA392482A publication Critical patent/ATA392482A/de
Application granted granted Critical
Publication of AT382079B publication Critical patent/AT382079B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
AT0392482A 1981-10-30 1982-10-27 Verfahren zur herstellung einer stabilisierten waesserigen insulinloesung AT382079B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK478681 1981-10-30
DK324782 1982-07-20

Publications (2)

Publication Number Publication Date
ATA392482A ATA392482A (de) 1986-06-15
AT382079B true AT382079B (de) 1987-01-12

Family

ID=26066963

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0392482A AT382079B (de) 1981-10-30 1982-10-27 Verfahren zur herstellung einer stabilisierten waesserigen insulinloesung

Country Status (20)

Country Link
US (1) US4614730A (de)
AT (1) AT382079B (de)
AU (1) AU549593B2 (de)
BE (1) BE894885A (de)
CA (1) CA1198673A (de)
CH (1) CH649922A5 (de)
DE (1) DE3240177A1 (de)
ES (1) ES516963A0 (de)
FI (1) FI80595C (de)
FR (1) FR2515517B1 (de)
GB (1) GB2107985B (de)
GR (1) GR77360B (de)
IE (1) IE54029B1 (de)
IT (1) IT1153315B (de)
LU (1) LU84447A1 (de)
NL (1) NL193099C (de)
NO (1) NO168086C (de)
NZ (1) NZ202328A (de)
PT (1) PT75766B (de)
SE (1) SE460576B (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
EP0179904A1 (de) * 1984-05-09 1986-05-07 Medaphore Inc. Orales insulin und verfahren zu seiner herstellung
DE3443877A1 (de) * 1984-06-09 1985-12-12 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung
CA1257199A (en) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
FR2605449B1 (fr) * 1986-10-17 1988-12-02 Thomson Cgr Bloc magnetique a aimantation ajustable pour la production d'un champ magnetique permanent dans une zone d'interet
NZ222907A (en) * 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
US5179079A (en) * 1986-12-16 1993-01-12 Novo Nordisk A/S Nasal formulation and intranasal administration therewith
US5266310A (en) * 1987-09-17 1993-11-30 Boehringer Ingelheim International Gmbh Stabilization of therapeutically active proteins in pharmaceutical preparations
NO179479C (no) * 1988-03-11 1996-10-16 Teikoku Seiyaku Kk Fremgangsmåte for fremstilling av et intravaginalt farmasöytisk preparat
US5725871A (en) * 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
ATE140034T1 (de) * 1990-04-17 1996-07-15 Analytical Control Syst Inc Koagulationsassays und reagenzien
DE4208552A1 (de) * 1992-03-17 1993-09-23 Liedtke Pharmed Gmbh Topische arzneiformen mit insulin
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US6214375B1 (en) 1996-07-16 2001-04-10 Generex Pharmaceuticals, Inc. Phospholipid formulations
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US6350458B1 (en) 1998-02-10 2002-02-26 Generex Pharmaceuticals Incorporated Mixed micellar drug deliver system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6290987B1 (en) 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
US6271200B1 (en) 1998-12-21 2001-08-07 Generex Pharmaceuticals Inc. Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6375975B1 (en) 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6451286B1 (en) 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US6436367B1 (en) 1998-12-21 2002-08-20 Generex Pharmaceuticals Inc. Aerosol formulations for buccal and pulmonary application
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
US20030068361A1 (en) * 2001-10-09 2003-04-10 Rimona Margalit Liposome-encapsulated insulin formulations
ES2360182T3 (es) 2002-05-07 2011-06-01 Novo Nordisk A/S Formulaciones solubles que comprenden insulina monomérica e insulina acilada.
US20040018237A1 (en) 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US8435942B2 (en) * 2002-05-31 2013-05-07 Transdermal Biotechnology, Inc. Methods for formulating stabilized insulin compositions
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US8911751B2 (en) * 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
WO2010043566A2 (de) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Kombination von einem insulin und einem glp-1-agonisten
US9707176B2 (en) 2009-11-13 2017-07-18 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist and methionine
ES2855146T3 (es) 2009-11-13 2021-09-23 Sanofi Aventis Deutschland Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
WO2012006956A1 (zh) 2010-07-14 2012-01-19 中国医学科学院药物研究所 一种胰岛素的脂质复合物及其制备方法和制剂
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
CN103547258B (zh) 2011-03-17 2017-10-20 特兰斯德梅尔生物工艺股份有限公司 局部一氧化氮***及其使用方法
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PT2750699E (pt) 2011-08-29 2015-11-03 Sanofi Aventis Deutschland Acelerómetro pendular
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
HUE055231T2 (hu) 2016-12-16 2021-11-29 Novo Nordisk As Inzulint tartalmazó gyógyászati készítmények
EP3654942A1 (de) 2017-07-20 2020-05-27 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Pharmazeutische filmzusammensetzungen zur verabreichung von lipophilen verbindungen in die haut und / oder über die haut

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50116028A (de) * 1974-02-26 1975-09-11
DE2601207A1 (de) * 1975-01-27 1976-07-29 Tanabe Seiyaku Co Verfahren zur herstellung einer fluessigen zubereitung mit gesteuertem abgabevermoegen

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2563070A (en) * 1947-12-19 1951-08-07 Chicago Medical School Antidiabetic
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product
US4153689A (en) * 1975-06-13 1979-05-08 Takeda Chemical Industries, Ltd. Stable insulin preparation for nasal administration
US4164573A (en) * 1975-06-13 1979-08-14 Galinsky Alvin M Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
DE2652636A1 (de) * 1976-11-19 1978-05-24 Hans Uwe Dr Rer Nat Wolf Verfahren zur stabilisierung von proteinen und verwandten verbindungen waehrend ihrer reinigung, isolierung und lagerung
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
DE2952119A1 (de) * 1979-12-22 1981-07-09 Hoechst Ag, 6230 Frankfurt Gegen denaturierung bestaendige, waessrige protein-loesungen
EP0032622B1 (de) * 1979-12-20 1985-08-14 Dennis Chapman Polymerisationsfähige Phospholipide und deren Polymere, Verfahren zu deren Herstellung, Verfahren zu deren Verwendung für die Bildung von Überzugschichten auf Substraten und zum Bilden von Liposomen und die daraus entstehenden Liposomzusammensetzungen und Substrate mit Überzugschichten

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50116028A (de) * 1974-02-26 1975-09-11
DE2601207A1 (de) * 1975-01-27 1976-07-29 Tanabe Seiyaku Co Verfahren zur herstellung einer fluessigen zubereitung mit gesteuertem abgabevermoegen

Also Published As

Publication number Publication date
US4614730A (en) 1986-09-30
AU549593B2 (en) 1986-01-30
PT75766B (en) 1985-12-09
GR77360B (de) 1984-09-11
FR2515517B1 (fr) 1987-07-03
NL193099C (nl) 1998-11-03
AU8986182A (en) 1983-05-05
ES8403025A1 (es) 1984-03-01
IE822602L (en) 1983-04-30
FI80595B (fi) 1990-03-30
FI823702A0 (fi) 1982-10-29
ES516963A0 (es) 1984-03-01
NZ202328A (en) 1985-07-12
SE8206168L (sv) 1983-05-01
BE894885A (fr) 1983-04-29
NL8203944A (nl) 1983-05-16
IE54029B1 (en) 1989-05-24
FI80595C (fi) 1990-07-10
SE460576B (sv) 1989-10-30
DE3240177A1 (de) 1983-05-11
ATA392482A (de) 1986-06-15
NL193099B (nl) 1998-07-01
CH649922A5 (de) 1985-06-28
LU84447A1 (fr) 1983-06-13
DE3240177C2 (de) 1993-07-22
FR2515517A1 (fr) 1983-05-06
GB2107985B (en) 1984-11-14
NO168086B (no) 1991-10-07
FI823702L (fi) 1983-05-01
NO823603L (no) 1983-05-02
NO168086C (no) 1992-01-15
PT75766A (en) 1982-11-01
IT8223990A0 (it) 1982-10-29
SE8206168D0 (sv) 1982-10-29
GB2107985A (en) 1983-05-11
IT1153315B (it) 1987-01-14
CA1198673A (en) 1985-12-31

Similar Documents

Publication Publication Date Title
AT382079B (de) Verfahren zur herstellung einer stabilisierten waesserigen insulinloesung
AT382780B (de) Verfahren zur herstellung einer insulinloesung
DE68906310D1 (de) Verfahren zur herstellung einer stabilisierten waessrigen loesung von chlordioxid.
AT372281B (de) Verfahren zur herstellung einer nutriens-verbindung
AT360148B (de) Verfahren zur herstellung einer stabilen injektionsloesung
AT385201B (de) Verfahren zur herstellung einer antiinflammatorischen ophthalmischen loesung
DE3676124D1 (de) Verfahren zur herstellung einer beschichteten mikrotomoklinge.
DE3577239D1 (de) Verfahren zur herstellung einer silberhalogenidemulsion.
AT387142B (de) Verfahren zur herstellung einer nitrofurantoin-dosierungsform
DE3482214D1 (de) Verfahren zur herstellung einer silberhalogenidemulsion.
AT368528B (de) Verfahren zur herstellung einer katalytischen titankomponente
DE3580350D1 (de) Verfahren zur herstellung einer frukto-oligosaccharose.
DE3672928D1 (de) Verfahren zur herstellung einer nachgiebigen walze.
AT373630B (de) Verfahren zur herstellung einer beschichtungsmasse
DE3868669D1 (de) Verfahren zur herstellung einer polyglycidylamin-verbindung.
DE3685220D1 (de) Verfahren zur herstellung einer abdichtung.
DE3667276D1 (de) Verfahren zur herstellung einer azidosulfonylbenzoesaeure.
ATA92982A (de) Verfahren zur herstellung einer pharmazeutischen, parenteralen dosiseinheit von na-piperacillin
DE3668428D1 (de) Verfahren zur herstellung einer ziehmatrize.
ATA206287A (de) Verfahren zur herstellung einer backware
DE3871786T2 (de) Verfahren zur herstellung einer rhodiumnitrat-loesung.
DE3784961D1 (de) Verfahren zur herstellung einer verbindungsleitung.
AT376879B (de) Verfahren zur herstellung einer injektionsloesung
DD138506A1 (de) Verfahren zur herstellung einer waessrigen loesung
AT352882B (de) Verfahren zur herstellung einer stabilisierten theophyllin enthaltenden waesserigen loesung

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee