LU79937A1 - Neue 1-acyl-2-cyanaziridine,verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen - Google Patents

Neue 1-acyl-2-cyanaziridine,verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen Download PDF

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Publication number
LU79937A1
LU79937A1 LU79937A LU79937A LU79937A1 LU 79937 A1 LU79937 A1 LU 79937A1 LU 79937 A LU79937 A LU 79937A LU 79937 A LU79937 A LU 79937A LU 79937 A1 LU79937 A1 LU 79937A1
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LU
Luxembourg
Prior art keywords
cyanaziridine
acyl
compounds
new
production
Prior art date
Application number
LU79937A
Other languages
English (en)
Inventor
H Berger
R Kuhn
W Kampe
R Gall
U Bicker
Original Assignee
Boehringer Mannheim Gmbh
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Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of LU79937A1 publication Critical patent/LU79937A1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F42—AMMUNITION; BLASTING
    • F42B—EXPLOSIVE CHARGES, e.g. FOR BLASTING, FIREWORKS, AMMUNITION
    • F42B3/00—Blasting cartridges, i.e. case and explosive
    • F42B3/087—Flexible or deformable blasting cartridges, e.g. bags or hoses for slurries

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
LU79937A 1977-07-11 1978-07-07 Neue 1-acyl-2-cyanaziridine,verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen LU79937A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772731264 DE2731264A1 (de) 1977-07-11 1977-07-11 Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Publications (1)

Publication Number Publication Date
LU79937A1 true LU79937A1 (de) 1980-02-14

Family

ID=6013651

Family Applications (1)

Application Number Title Priority Date Filing Date
LU79937A LU79937A1 (de) 1977-07-11 1978-07-07 Neue 1-acyl-2-cyanaziridine,verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen

Country Status (26)

Country Link
US (1) US4267174A (de)
JP (1) JPS5436254A (de)
AT (1) AT356663B (de)
AU (2) AU519219B2 (de)
BE (1) BE868796A (de)
CA (1) CA1086309A (de)
CS (1) CS208656B2 (de)
DD (1) DD137710A5 (de)
DE (1) DE2731264A1 (de)
DK (1) DK306978A (de)
ES (1) ES471512A1 (de)
FI (1) FI782157A (de)
FR (1) FR2397403A1 (de)
GB (1) GB1594079A (de)
HU (1) HU179428B (de)
IL (1) IL55109A (de)
IT (1) IT1096910B (de)
LU (1) LU79937A1 (de)
NL (1) NL7807276A (de)
NO (1) NO782399L (de)
NZ (1) NZ187794A (de)
PL (1) PL126639B1 (de)
PT (1) PT68263A (de)
SE (1) SE7807642L (de)
SU (1) SU1077565A3 (de)
ZA (1) ZA783829B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2906603A1 (de) * 1979-02-21 1980-09-04 Boehringer Mannheim Gmbh N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
US4393000A (en) * 1979-12-12 1983-07-12 Mitsui Toatsu Chemicals, Inc. Cyclization process for producing aziridine-2-carboxylic acid or its salts
US4925835A (en) * 1986-05-01 1990-05-15 Sloan-Kettering Institute For Cancer Research Aziridinyl putrescine containing compositions and their uses in treating prostate cancer
US6982263B2 (en) * 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
EA011009B1 (ru) * 2003-01-14 2008-12-30 Арена Фармасьютикалз Инк. 1,2,3-тризамещённые арильные и гетероарильные производные в качестве модуляторов метаболизма и профилактика и лечение расстройств, связанных с ним, таких как диабет и гипергликемия
DK1606282T3 (da) * 2003-02-24 2009-03-16 Arena Pharm Inc Phenyl- og pyridylpipereidinye-derivater som modulatorer af glucosemetabolisme
AR045047A1 (es) * 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
SI1756084T1 (sl) * 2004-06-04 2009-04-30 Arena Pharm Inc Substituirani arilni in heteroarilni derivati kot modulatorji metabolizma ter profilaksa in zdravljenje motenj v zvezi s tem
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
RS20080112A (en) * 2005-09-16 2009-05-06 Arena Pharmaceuticals Inc., Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
EP2528894A1 (de) 2010-01-27 2012-12-05 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)essigsäure und salzen daraus
BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
US11007175B2 (en) 2015-01-06 2021-05-18 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
EP3939965A1 (de) 2015-06-22 2022-01-19 Arena Pharmaceuticals, Inc. Kristallines l-arginin-salz von (r)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)essigsäure zur verwendung in s1p1-rezeptor-assoziierten erkrankungen
EP3582772A1 (de) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Verbindungen und verfahren zur behandlung von primärer biliärer cholangitis
LV15518A (lv) * 2019-02-18 2020-08-20 Latvijas Organiskās Sintēzes Institūts Aziridīn-2-karboksamīda atvasinājumi kā tioredoksīnreduktāzes inhibitori ar pretvēža un pretmetastatisku iedarbību un to sintēze
EP4087650A1 (de) * 2020-01-10 2022-11-16 Uniwersytet Jagiellonski Aromatische sulfonamidderivate, die pdi a1 hemmen, ihre synthese und verwendung
EP4087651A1 (de) * 2020-01-10 2022-11-16 Uniwersytet Jagiellonski Aromatische sulfonamidderivate, die pdi a1 hemmen, ihre synthese und verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD110492A1 (de) * 1974-03-21 1974-12-20
JPS5932772B2 (ja) * 1974-09-21 1984-08-10 旭光学工業 （株） 照射光走査装置
DE2528460A1 (de) * 1975-06-26 1977-01-13 Boehringer Mannheim Gmbh Verwendung von l-carboxamido-2- cyan-aziridin als immunstimulans

Also Published As

Publication number Publication date
IT7825474A0 (it) 1978-07-07
FI782157A (fi) 1979-01-12
IL55109A (en) 1982-07-30
FR2397403A1 (fr) 1979-02-09
AU3782678A (en) 1980-01-10
DD137710A5 (de) 1979-09-19
PT68263A (de) 1978-08-01
NO782399L (no) 1979-01-12
ATA496478A (de) 1979-10-15
AT356663B (de) 1980-05-12
PL208195A1 (de) 1980-03-24
AU519219B2 (en) 1981-11-19
BE868796A (fr) 1979-01-08
HU179428B (en) 1982-10-28
DK306978A (da) 1979-01-12
DE2731264A1 (de) 1979-02-01
IL55109A0 (en) 1978-09-29
PL126639B1 (en) 1983-08-31
SE7807642L (sv) 1979-03-14
GB1594079A (en) 1981-07-30
AU3782578A (en) 1980-01-10
SU1077565A3 (ru) 1984-02-29
NL7807276A (nl) 1979-01-15
ES471512A1 (es) 1979-10-01
CS208656B2 (en) 1981-09-15
ZA783829B (en) 1980-03-26
US4267174A (en) 1981-05-12
JPS5436254A (en) 1979-03-16
CA1086309A (en) 1980-09-23
NZ187794A (en) 1980-05-08
IT1096910B (it) 1985-08-26

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