LT3532059T - Bromodomeno ir papildomo galinio baltymo inhibitorių derinio terapija - Google Patents
Bromodomeno ir papildomo galinio baltymo inhibitorių derinio terapijaInfo
- Publication number
- LT3532059T LT3532059T LTEPPCT/US2017/058614T LT17058614T LT3532059T LT 3532059 T LT3532059 T LT 3532059T LT 17058614 T LT17058614 T LT 17058614T LT 3532059 T LT3532059 T LT 3532059T
- Authority
- LT
- Lithuania
- Prior art keywords
- bromodomain
- extra
- combination therapy
- protein inhibitor
- terminal protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662413763P | 2016-10-27 | 2016-10-27 | |
US201762560840P | 2017-09-20 | 2017-09-20 | |
PCT/US2017/058614 WO2018081475A1 (en) | 2016-10-27 | 2017-10-26 | Bromodomain and extra-terminal protein inhibitor combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
LT3532059T true LT3532059T (lt) | 2022-05-25 |
Family
ID=62019758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEPPCT/US2017/058614T LT3532059T (lt) | 2016-10-27 | 2017-10-26 | Bromodomeno ir papildomo galinio baltymo inhibitorių derinio terapija |
Country Status (18)
Country | Link |
---|---|
US (4) | US10166227B2 (lt) |
EP (1) | EP3532059B1 (lt) |
JP (1) | JP7171557B2 (lt) |
KR (2) | KR102587839B1 (lt) |
AU (1) | AU2017347853B2 (lt) |
CA (1) | CA3041049A1 (lt) |
CY (1) | CY1125126T1 (lt) |
DK (1) | DK3532059T3 (lt) |
ES (1) | ES2907840T3 (lt) |
HR (1) | HRP20220375T1 (lt) |
HU (1) | HUE058289T2 (lt) |
LT (1) | LT3532059T (lt) |
PL (1) | PL3532059T3 (lt) |
PT (1) | PT3532059T (lt) |
RS (1) | RS63054B1 (lt) |
SI (1) | SI3532059T1 (lt) |
TW (1) | TW201821106A (lt) |
WO (1) | WO2018081475A1 (lt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10702517B2 (en) * | 2015-04-22 | 2020-07-07 | Celgene Quanticel Research, Inc. | Bromodomain inhibitor |
AU2017347853B2 (en) * | 2016-10-27 | 2022-02-17 | Celgene Quanticel Research, Inc. | Bromodomain and extra-terminal protein inhibitor combination therapy |
WO2019204758A1 (en) * | 2018-04-20 | 2019-10-24 | Zhiguo Zhang | Compositions and methods for treating glioblastoma by modulating a mgmt enhancer |
CN110211633B (zh) * | 2019-05-06 | 2021-08-31 | 臻和精准医学检验实验室无锡有限公司 | Mgmt基因启动子甲基化的检测方法、测序数据的处理方法及处理装置 |
AR127614A1 (es) * | 2021-11-10 | 2024-02-14 | Celgene Quanticel Res Inc | Métodos de tratamiento del glioblastoma |
WO2024050016A1 (en) | 2022-08-31 | 2024-03-07 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260291A (en) | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
GB8616125D0 (en) | 1986-07-02 | 1986-08-06 | May & Baker Ltd | Compositions of matter |
FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
GB9601603D0 (en) | 1996-01-26 | 1996-03-27 | Isis Innovations Ltd | Terpyridine-platinum (II) complexes |
EP1353924A1 (en) | 2001-01-18 | 2003-10-22 | Schering Corporation | Synthesis of temozolomide and analogs |
US7612202B2 (en) | 2005-02-17 | 2009-11-03 | Chemagis, Ltd. | Process for preparing temozolomide |
US20070166388A1 (en) | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
EP2066672B1 (en) | 2006-09-29 | 2015-06-24 | Cipla Limited | An improved process for the preparation of temozolomide and analogs |
DE102008034256A1 (de) | 2008-07-18 | 2010-01-21 | Technische Universität Dresden | Photoaktives Bauelement mit organischen Schichten |
WO2014080290A2 (en) * | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
CN105073744B (zh) * | 2012-12-21 | 2019-11-08 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新型杂环化合物 |
CA2904049A1 (en) * | 2013-03-11 | 2014-10-09 | Abbvie Inc. | Fused tetracyclic bromodomain inhibitors |
TWI527811B (zh) * | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
SG10201710705UA (en) * | 2013-06-21 | 2018-02-27 | Zenith Epigenetics Ltd | Novel bicyclic bromodomain inhibitors |
WO2015018522A1 (en) * | 2013-08-06 | 2015-02-12 | Oncoethix Sa | Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl) |
LT3640241T (lt) | 2013-10-18 | 2022-12-27 | Celgene Quanticel Research, Inc. | Bromodomeno inhibitoriai |
JP6637884B2 (ja) | 2013-11-08 | 2020-01-29 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ブロモドメインおよびエクストラターミナル(bet)タンパク質インヒビターを使用するがんのための併用療法 |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2016014859A1 (en) * | 2014-07-25 | 2016-01-28 | Pharmacyclics Llc | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations |
CA2966452A1 (en) * | 2014-12-17 | 2016-06-23 | Samuel David Brown | Substituted bicyclic compounds as bromodomain inhibitors |
TW201642860A (zh) * | 2015-04-22 | 2016-12-16 | 塞爾基因定量細胞研究公司 | 布羅莫結構域抑制劑 |
CN108883311A (zh) * | 2015-12-24 | 2018-11-23 | 赛尔基因昆蒂赛尔研究公司 | 布罗莫结构域和额外末端蛋白抑制剂组合疗法 |
AU2017347853B2 (en) * | 2016-10-27 | 2022-02-17 | Celgene Quanticel Research, Inc. | Bromodomain and extra-terminal protein inhibitor combination therapy |
-
2017
- 2017-10-26 AU AU2017347853A patent/AU2017347853B2/en active Active
- 2017-10-26 JP JP2019522408A patent/JP7171557B2/ja active Active
- 2017-10-26 WO PCT/US2017/058614 patent/WO2018081475A1/en unknown
- 2017-10-26 DK DK17864117.1T patent/DK3532059T3/da active
- 2017-10-26 PT PT178641171T patent/PT3532059T/pt unknown
- 2017-10-26 LT LTEPPCT/US2017/058614T patent/LT3532059T/lt unknown
- 2017-10-26 KR KR1020237014461A patent/KR102587839B1/ko active IP Right Grant
- 2017-10-26 PL PL17864117T patent/PL3532059T3/pl unknown
- 2017-10-26 KR KR1020197014146A patent/KR102528406B1/ko active IP Right Grant
- 2017-10-26 EP EP17864117.1A patent/EP3532059B1/en active Active
- 2017-10-26 HU HUE17864117A patent/HUE058289T2/hu unknown
- 2017-10-26 ES ES17864117T patent/ES2907840T3/es active Active
- 2017-10-26 HR HRP20220375TT patent/HRP20220375T1/hr unknown
- 2017-10-26 SI SI201731079T patent/SI3532059T1/sl unknown
- 2017-10-26 RS RS20220280A patent/RS63054B1/sr unknown
- 2017-10-26 CA CA3041049A patent/CA3041049A1/en active Pending
- 2017-10-27 TW TW106137075A patent/TW201821106A/zh unknown
- 2017-10-27 US US15/796,571 patent/US10166227B2/en active Active
-
2018
- 2018-11-14 US US16/191,319 patent/US10576075B2/en active Active
-
2020
- 2020-01-23 US US16/750,996 patent/US10881655B2/en active Active
- 2020-09-25 US US17/033,311 patent/US11464771B2/en active Active
-
2022
- 2022-03-21 CY CY20221100226T patent/CY1125126T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR20230078758A (ko) | 2023-06-02 |
US11464771B2 (en) | 2022-10-11 |
HUE058289T2 (hu) | 2022-07-28 |
US20210008056A1 (en) | 2021-01-14 |
US10166227B2 (en) | 2019-01-01 |
WO2018081475A1 (en) | 2018-05-03 |
EP3532059B1 (en) | 2022-01-26 |
US10576075B2 (en) | 2020-03-03 |
KR20190088979A (ko) | 2019-07-29 |
DK3532059T3 (da) | 2022-03-14 |
CA3041049A1 (en) | 2018-05-03 |
US10881655B2 (en) | 2021-01-05 |
PL3532059T3 (pl) | 2022-05-09 |
KR102587839B1 (ko) | 2023-10-11 |
RS63054B1 (sr) | 2022-04-29 |
EP3532059A4 (en) | 2020-05-20 |
AU2017347853A1 (en) | 2019-05-30 |
TW201821106A (zh) | 2018-06-16 |
KR102528406B1 (ko) | 2023-05-03 |
SI3532059T1 (sl) | 2022-06-30 |
US20190083483A1 (en) | 2019-03-21 |
US20180117030A1 (en) | 2018-05-03 |
ES2907840T3 (es) | 2022-04-26 |
HRP20220375T1 (hr) | 2022-05-13 |
JP7171557B2 (ja) | 2022-11-15 |
EP3532059A1 (en) | 2019-09-04 |
US20200155539A1 (en) | 2020-05-21 |
CY1125126T1 (el) | 2023-06-09 |
PT3532059T (pt) | 2022-03-02 |
JP2019535682A (ja) | 2019-12-12 |
AU2017347853B2 (en) | 2022-02-17 |
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