LT3194376T - Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitratdehidrogenazės inhibitoriai - Google Patents

Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitratdehidrogenazės inhibitoriai

Info

Publication number: LT3194376T
Authority: LT; Lithuania
Prior art keywords: pyridin; mutant; isocitrate dehydrogenase; dehydrogenase inhibitors; quinolinone derivatives
Prior art date: 2014-09-19

Application number

LTEP15778433.1T

Other languages

English (en)

Inventor

Susan Ashwell

Ann-Marie Campbell

Justin Andrew CARAVELLA

R. Bruce DIEBOLD

Anna Ericsson

Gary Gustafson

Lancia, Jr.

Jian Lin

Wei Lu

Zhongguo Wang

Original Assignee

Forma Therapeutics, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-09-19

Filing date

2015-09-18

Publication date

2019-02-25

2015-09-18 Application filed by Forma Therapeutics, Inc. filed Critical Forma Therapeutics, Inc.

2019-02-25 Publication of LT3194376T publication Critical patent/LT3194376T/lt

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines

LTEP15778433.1T 2014-09-19 2015-09-18 Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitratdehidrogenazės inhibitoriai LT3194376T (lt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201462053006P	2014-09-19	2014-09-19
US201562128089P	2015-03-04	2015-03-04
US201562150812P	2015-04-21	2015-04-21
PCT/US2015/051055 WO2016044789A1 (en)	2014-09-19	2015-09-18	Pyridin-2(1h)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

Publications (1)

Publication Number	Publication Date
LT3194376T true LT3194376T (lt)	2019-02-25

Family

ID=54291606

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEP15778433.1T LT3194376T (lt)	2014-09-19	2015-09-18	Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitratdehidrogenazės inhibitoriai
LTEP18198969.0T LT3447050T (lt)	2014-09-19	2015-09-18	Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitrato dehidrogenazės inhibitoriai

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTEP18198969.0T LT3447050T (lt)	2014-09-19	2015-09-18	Piridin-2(1h)-ono chinolinono dariniai, kaip mutantinės izocitrato dehidrogenazės inhibitoriai

Country Status (36)

Country	Link
US (8)	US9834539B2 (lt)
EP (4)	EP3194376B1 (lt)
JP (1)	JP6648115B2 (lt)
KR (1)	KR102209667B1 (lt)
CN (3)	CN117695280A (lt)
AU (3)	AU2015317329B2 (lt)
BR (1)	BR112017005238B1 (lt)
CA (1)	CA2961817C (lt)
CL (1)	CL2017000658A1 (lt)
CO (1)	CO2017003241A2 (lt)
CY (2)	CY1121149T1 (lt)
DK (2)	DK3194376T3 (lt)
EA (1)	EA034336B1 (lt)
EC (1)	ECSP17022933A (lt)
ES (3)	ES2790640T3 (lt)
FI (1)	FI3733662T3 (lt)
HR (1)	HRP20200666T1 (lt)
HU (2)	HUE041460T2 (lt)
IL (3)	IL292608A (lt)
LT (2)	LT3194376T (lt)
MA (2)	MA40481A (lt)
ME (1)	ME03776B (lt)
MX (2)	MX2017003404A (lt)
MY (2)	MY197533A (lt)
NZ (2)	NZ730373A (lt)
PE (1)	PE20171056A1 (lt)
PH (1)	PH12017500517A1 (lt)
PL (3)	PL3733662T3 (lt)
PT (3)	PT3733662T (lt)
RS (2)	RS60140B1 (lt)
SA (1)	SA517381129B1 (lt)
SG (1)	SG11201702194SA (lt)
SI (2)	SI3447050T1 (lt)
TW (1)	TWI686390B (lt)
WO (1)	WO2016044789A1 (lt)
ZA (2)	ZA201702127B (lt)

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KR20170049604A (ko)	2014-09-19	2017-05-10	바이엘 파마 악티엔게젤샤프트	Bub1 억제제로서의 벤질 치환된 인다졸
CA2961793C (en)	2014-09-19	2021-03-16	Forma Therapeutics, Inc.	Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
PL3733662T3 (pl)	2014-09-19	2024-01-22	Forma Therapeutics, Inc.	Chinolinonowe pochodne pirydyn-2(1H)-onu jako inhibitory zmutowanej dehydrogenazy izocytrynianowej
EP3201185B1 (en)	2014-09-19	2018-11-21	Forma Therapeutics, Inc.	Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
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EP3619196B1 (de)	2017-05-04	2022-03-30	Bayer CropScience Aktiengesellschaft	2-{[2-(phenyloxymethyl)pyridin-5-yl]oxy}-ethanamin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel z.b. für den pflanzenschutz
US20210196701A1 (en)	2018-05-16	2021-07-01	Forma Therapeutics, Inc.	Inhibiting mutant idh-1
WO2019222551A1 (en)	2018-05-16	2019-11-21	Forma Therapeutics, Inc.	Solid forms of ((s)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile
SI3720442T1 (sl)	2018-05-16	2023-06-30	Forma Therapeutics, Inc.	Zaviranje mutantnega IDF-1
WO2020232381A1 (en)	2019-05-16	2020-11-19	Forma Therapeutics, Inc.	INHIBITING MUTANT ISOCITRATE DEHYDROGENASE 1 (mIDH-1)
US11311527B2 (en)	2018-05-16	2022-04-26	Forma Therapeutics, Inc.	Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
US11013733B2 (en)	2018-05-16	2021-05-25	Forma Therapeutics, Inc.	Inhibiting mutant isocitrate dehydrogenase 1 (mlDH-1)
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CN112341389B (zh) *	2020-10-27	2022-07-29	浙江工业大学	一种含氮芳杂环取代的喹啉甲酰胺类衍生物及其应用
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2015
- 2015-09-18 PL PL20157755.8T patent/PL3733662T3/pl unknown
- 2015-09-18 SI SI201531117T patent/SI3447050T1/sl unknown
- 2015-09-18 PE PE2017000471A patent/PE20171056A1/es unknown
- 2015-09-18 MX MX2017003404A patent/MX2017003404A/es active IP Right Grant
- 2015-09-18 FI FIEP20157755.8T patent/FI3733662T3/fi active
- 2015-09-18 AU AU2015317329A patent/AU2015317329B2/en active Active
- 2015-09-18 EP EP15778433.1A patent/EP3194376B1/en active Active
- 2015-09-18 PL PL18198969T patent/PL3447050T3/pl unknown
- 2015-09-18 NZ NZ73037315A patent/NZ730373A/en unknown
- 2015-09-18 RS RS20200418A patent/RS60140B1/sr unknown
- 2015-09-18 HU HUE15778433A patent/HUE041460T2/hu unknown
- 2015-09-18 JP JP2017515059A patent/JP6648115B2/ja active Active
- 2015-09-18 EP EP23176702.1A patent/EP4257131A3/en active Pending
- 2015-09-18 DK DK15778433.1T patent/DK3194376T3/en active
- 2015-09-18 EP EP20157755.8A patent/EP3733662B1/en active Active
- 2015-09-18 MY MYPI2020001463A patent/MY197533A/en unknown
- 2015-09-18 PL PL15778433T patent/PL3194376T3/pl unknown
- 2015-09-18 SG SG11201702194SA patent/SG11201702194SA/en unknown
- 2015-09-18 ES ES18198969T patent/ES2790640T3/es active Active
- 2015-09-18 US US14/858,167 patent/US9834539B2/en active Active
- 2015-09-18 PT PT201577558T patent/PT3733662T/pt unknown
- 2015-09-18 IL IL292608A patent/IL292608A/en unknown
- 2015-09-18 ES ES15778433T patent/ES2704897T3/es active Active
- 2015-09-18 WO PCT/US2015/051055 patent/WO2016044789A1/en active Application Filing
- 2015-09-18 SI SI201530537T patent/SI3194376T1/sl unknown
- 2015-09-18 CN CN202311265288.0A patent/CN117695280A/zh active Pending
- 2015-09-18 EP EP18198969.0A patent/EP3447050B1/en active Active
- 2015-09-18 NZ NZ758641A patent/NZ758641A/en unknown
- 2015-09-18 PT PT181989690T patent/PT3447050T/pt unknown
- 2015-09-18 CN CN201580050441.5A patent/CN107001328B/zh active Active
- 2015-09-18 RS RS20181586A patent/RS58184B1/sr unknown
- 2015-09-18 TW TW104131044A patent/TWI686390B/zh active
- 2015-09-18 BR BR112017005238-5A patent/BR112017005238B1/pt active IP Right Grant
- 2015-09-18 HU HUE20157755A patent/HUE062424T2/hu unknown
- 2015-09-18 ES ES20157755T patent/ES2953347T3/es active Active
- 2015-09-18 EA EA201790657A patent/EA034336B1/ru unknown
- 2015-09-18 DK DK18198969.0T patent/DK3447050T3/da active
- 2015-09-18 ME MEP-2020-78A patent/ME03776B/me unknown
- 2015-09-18 CA CA2961817A patent/CA2961817C/en active Active
- 2015-09-18 KR KR1020177010585A patent/KR102209667B1/ko active IP Right Grant
- 2015-09-18 LT LTEP15778433.1T patent/LT3194376T/lt unknown
- 2015-09-18 MA MA040481A patent/MA40481A/fr unknown
- 2015-09-18 CN CN202010391529.6A patent/CN111909130B/zh active Active
- 2015-09-18 MY MYPI2017700895A patent/MY176250A/en unknown
- 2015-09-18 MA MA053352A patent/MA53352A/fr unknown
- 2015-09-18 PT PT15778433T patent/PT3194376T/pt unknown
- 2015-09-18 LT LTEP18198969.0T patent/LT3447050T/lt unknown
2017
- 2017-03-07 US US15/452,256 patent/US20170174658A1/en not_active Abandoned
- 2017-03-14 IL IL251163A patent/IL251163B/en active IP Right Grant
- 2017-03-15 MX MX2019013203A patent/MX2019013203A/es unknown
- 2017-03-17 PH PH12017500517A patent/PH12017500517A1/en unknown
- 2017-03-17 CL CL2017000658A patent/CL2017000658A1/es unknown
- 2017-03-19 SA SA517381129A patent/SA517381129B1/ar unknown
- 2017-03-27 ZA ZA2017/02127A patent/ZA201702127B/en unknown
- 2017-04-03 CO CONC2017/0003241A patent/CO2017003241A2/es unknown
- 2017-04-13 EC ECIEPI201722933A patent/ECSP17022933A/es unknown
2018
- 2018-04-27 US US15/964,844 patent/US10414752B2/en active Active
2019
- 2019-01-21 CY CY20191100075T patent/CY1121149T1/el unknown
- 2019-03-01 US US16/290,240 patent/US10550098B2/en active Active
- 2019-04-17 ZA ZA2019/02446A patent/ZA201902446B/en unknown
- 2019-12-12 US US16/712,951 patent/US10889567B2/en active Active
- 2019-12-16 AU AU2019283765A patent/AU2019283765B2/en active Active
2020
- 2020-04-24 HR HRP20200666TT patent/HRP20200666T1/hr unknown
- 2020-05-04 CY CY20201100407T patent/CY1122865T1/el unknown
- 2020-11-23 US US17/101,018 patent/US11498913B2/en active Active
2021
- 2021-04-18 IL IL282363A patent/IL282363B/en unknown
- 2021-08-10 AU AU2021215141A patent/AU2021215141B2/en active Active
2022
- 2022-11-09 US US17/984,069 patent/US20230125739A1/en not_active Abandoned
2023
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KR102209667B1 (ko)	2021-01-29

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