ECSP17022933A - Derivados de piridin-2 (1h)-on quinolinona como inhibidores de isocitrato deshidrogenasa mutante - Google Patents

Derivados de piridin-2 (1h)-on quinolinona como inhibidores de isocitrato deshidrogenasa mutante

Info

Publication number
ECSP17022933A
ECSP17022933A ECIEPI201722933A ECPI201722933A ECSP17022933A EC SP17022933 A ECSP17022933 A EC SP17022933A EC IEPI201722933 A ECIEPI201722933 A EC IEPI201722933A EC PI201722933 A ECPI201722933 A EC PI201722933A EC SP17022933 A ECSP17022933 A EC SP17022933A
Authority
EC
Ecuador
Prior art keywords
inhibitors
mutant
quinolinone
pyridin
derivatives
Prior art date
Application number
ECIEPI201722933A
Other languages
English (en)
Inventor
Inc Pepsico
Familia S A Productos
Inc Apple
Group Ag Adecco
Ann-Marie Campbell
Global S L Findasense
Ag Novartis
Enterprises R D S L U Jafer
Anna Ericsson
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of ECSP17022933A publication Critical patent/ECSP17022933A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a inhibidores de proteínas de isocitrato deshidrogenasa mutante (mt-IDH) con actividad neomórfica útiles en el tratamiento de trastornos de proliferación celular y cánceres, que tienen la Fórmula: consta gráfico donde A, U, W1, W2, W3, R1-R6, y R9 se describen en la presente.
ECIEPI201722933A 2014-09-19 2017-04-13 Derivados de piridin-2 (1h)-on quinolinona como inhibidores de isocitrato deshidrogenasa mutante ECSP17022933A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053006P 2014-09-19 2014-09-19
US201562128089P 2015-03-04 2015-03-04
US201562150812P 2015-04-21 2015-04-21

Publications (1)

Publication Number Publication Date
ECSP17022933A true ECSP17022933A (es) 2017-08-31

Family

ID=54291606

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201722933A ECSP17022933A (es) 2014-09-19 2017-04-13 Derivados de piridin-2 (1h)-on quinolinona como inhibidores de isocitrato deshidrogenasa mutante

Country Status (36)

Country Link
US (8) US9834539B2 (es)
EP (4) EP3194376B1 (es)
JP (1) JP6648115B2 (es)
KR (1) KR102209667B1 (es)
CN (3) CN117695280A (es)
AU (3) AU2015317329B2 (es)
BR (1) BR112017005238B1 (es)
CA (1) CA2961817C (es)
CL (1) CL2017000658A1 (es)
CO (1) CO2017003241A2 (es)
CY (2) CY1121149T1 (es)
DK (2) DK3447050T3 (es)
EA (1) EA034336B1 (es)
EC (1) ECSP17022933A (es)
ES (3) ES2953347T3 (es)
FI (1) FI3733662T3 (es)
HR (1) HRP20200666T1 (es)
HU (2) HUE062424T2 (es)
IL (3) IL292608A (es)
LT (2) LT3194376T (es)
MA (2) MA40481A (es)
ME (1) ME03776B (es)
MX (2) MX2017003404A (es)
MY (2) MY176250A (es)
NZ (2) NZ758641A (es)
PE (1) PE20171056A1 (es)
PH (1) PH12017500517A1 (es)
PL (3) PL3194376T3 (es)
PT (3) PT3447050T (es)
RS (2) RS60140B1 (es)
SA (1) SA517381129B1 (es)
SG (1) SG11201702194SA (es)
SI (2) SI3194376T1 (es)
TW (1) TWI686390B (es)
WO (1) WO2016044789A1 (es)
ZA (2) ZA201702127B (es)

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HUE041460T2 (hu) 2019-05-28
CN111909130A (zh) 2020-11-10
MY197533A (en) 2023-06-21
AU2019283765A1 (en) 2020-01-16
EP3447050B1 (en) 2020-02-19
ME03776B (me) 2021-04-20
HRP20200666T1 (hr) 2020-07-24
ZA201702127B (en) 2019-06-26
DK3447050T3 (da) 2020-03-09
EP3194376A1 (en) 2017-07-26
NZ758641A (en) 2023-12-22
AU2021215141A1 (en) 2021-09-02
EP3447050A1 (en) 2019-02-27
CL2017000658A1 (es) 2017-12-22
US9834539B2 (en) 2017-12-05
IL282363A (en) 2021-06-30
EA201790657A8 (ru) 2018-02-28
FI3733662T3 (fi) 2023-08-09
PT3447050T (pt) 2020-09-17
US20230125739A1 (en) 2023-04-27
US20180312487A1 (en) 2018-11-01
US20190263778A1 (en) 2019-08-29
IL282363B (en) 2022-06-01
NZ730373A (en) 2019-11-29
HUE062424T2 (hu) 2023-11-28
US11498913B2 (en) 2022-11-15
ES2953347T3 (es) 2023-11-10
BR112017005238B1 (pt) 2023-01-17
ES2704897T3 (es) 2019-03-20
CY1122865T1 (el) 2021-05-05
EP3733662A1 (en) 2020-11-04
MX2019013203A (es) 2020-01-20
CO2017003241A2 (es) 2017-09-20
SG11201702194SA (en) 2017-04-27
MY176250A (en) 2020-07-24
US10550098B2 (en) 2020-02-04
CN117695280A (zh) 2024-03-15
AU2015317329B2 (en) 2019-10-31
MA40481A (fr) 2017-07-26
PL3447050T3 (pl) 2020-07-27
PL3194376T3 (pl) 2019-05-31
IL251163A0 (en) 2017-04-30
RS58184B1 (sr) 2019-03-29
CA2961817C (en) 2024-03-12
EP4257131A3 (en) 2024-01-10
CN107001328B (zh) 2020-06-05
JP6648115B2 (ja) 2020-02-14
MX2017003404A (es) 2017-07-28
EP4257131A2 (en) 2023-10-11
SA517381129B1 (ar) 2021-04-26
AU2015317329A1 (en) 2017-04-27
US20170174658A1 (en) 2017-06-22
ZA201902446B (en) 2023-12-20
IL292608A (en) 2022-07-01
JP2017528487A (ja) 2017-09-28
SI3447050T1 (sl) 2020-08-31
EA201790657A1 (ru) 2017-08-31
KR102209667B1 (ko) 2021-01-29
US10414752B2 (en) 2019-09-17
BR112017005238A2 (pt) 2017-12-19
PT3733662T (pt) 2023-08-18
LT3194376T (lt) 2019-02-25
CY1121149T1 (el) 2020-05-29
TWI686390B (zh) 2020-03-01
TW201617335A (zh) 2016-05-16
LT3447050T (lt) 2020-05-11
RS60140B1 (sr) 2020-05-29
AU2019283765B2 (en) 2021-05-13
EP3733662B1 (en) 2023-06-07
IL251163B (en) 2021-05-31
PH12017500517A1 (en) 2017-08-07
SI3194376T1 (sl) 2019-03-29
US20210078973A1 (en) 2021-03-18
US20240150319A1 (en) 2024-05-09
PL3733662T3 (pl) 2024-01-22
ES2790640T3 (es) 2020-10-28
CA2961817A1 (en) 2016-03-24
US10889567B2 (en) 2021-01-12
US20160083366A1 (en) 2016-03-24
EA034336B1 (ru) 2020-01-29
AU2021215141B2 (en) 2023-10-19
US20200223822A1 (en) 2020-07-16
PE20171056A1 (es) 2017-07-21
WO2016044789A1 (en) 2016-03-24
CN111909130B (zh) 2023-10-31
KR20170063742A (ko) 2017-06-08
PT3194376T (pt) 2019-02-04
MA53352A (fr) 2021-09-15
CN107001328A (zh) 2017-08-01
DK3194376T3 (en) 2019-01-21
EP3194376B1 (en) 2018-10-24

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