LT2658844T - Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopiklių - Google Patents
Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopikliųInfo
- Publication number
- LT2658844T LT2658844T LTEP11805849.4T LT11805849T LT2658844T LT 2658844 T LT2658844 T LT 2658844T LT 11805849 T LT11805849 T LT 11805849T LT 2658844 T LT2658844 T LT 2658844T
- Authority
- LT
- Lithuania
- Prior art keywords
- pkb
- akt
- preparation
- pharmaceutical use
- pyrimidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1061303A FR2969607B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de thiopyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061298A FR2969609B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de 6-oxo-dihydro-pyrimidine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061297A FR2969608B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (5-halo-6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061301A FR2969614A1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de pyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061300A FR2969610B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-indolinamide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1159313 | 2011-10-14 | ||
| FR1159315 | 2011-10-14 | ||
| FR1159316 | 2011-10-14 | ||
| FR1159317 | 2011-10-14 | ||
| PCT/EP2011/073875 WO2012089633A1 (fr) | 2010-12-28 | 2011-12-22 | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2658844T true LT2658844T (lt) | 2017-02-10 |
Family
ID=45464546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP11805849.4T LT2658844T (lt) | 2010-12-28 | 2011-12-22 | Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopiklių |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133168B2 (lt) |
| EP (1) | EP2658844B1 (lt) |
| CY (1) | CY1118858T1 (lt) |
| DK (1) | DK2658844T3 (lt) |
| ES (1) | ES2612492T3 (lt) |
| HR (1) | HRP20170119T1 (lt) |
| HU (1) | HUE030393T2 (lt) |
| LT (1) | LT2658844T (lt) |
| PL (1) | PL2658844T3 (lt) |
| PT (1) | PT2658844T (lt) |
| SI (1) | SI2658844T1 (lt) |
| WO (1) | WO2012089633A1 (lt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819422A (zh) * | 2014-03-18 | 2014-05-28 | 南通佰华生物医药研究有限公司 | 一种制备手性n-取代-2-吗啉甲醇类化合物的方法 |
| SG11201609540TA (en) | 2014-06-13 | 2016-12-29 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| US11021467B2 (en) | 2014-06-13 | 2021-06-01 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| EA201692266A1 (ru) | 2014-06-13 | 2017-06-30 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
| BR112016028814A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | ?composição farmacêutica, métodos de tratamento de uma doença ou condição, de inibição de reações imunitárias ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, composto, um sal, um isômero, ou uma mistura farmaceuticamente aceitável do mesmo, e, uso de um composto, de um sal, de um isômero, ou de uma mistura farmaceuticamente aceitável do mesmo? |
| BR112016028818A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | composição farmacêutica, métodos de tratamento de uma doença ou condição, de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase e de inibição de reações imunes excessivas ou destrutivas ou crescimento ou proliferação de células cancerosas, kit, composto, sal, isômero, ou uma mistura farmaceuticamente aceitável do mesmo, e, uso de um composto, um sal, isômero, ou uma mistura farmaceuticamente aceitável do mesmo. |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CN106966951B (zh) * | 2017-04-21 | 2020-01-31 | 常州佳德医药科技有限公司 | 4-氟-2-甲基吲哚及其制备方法和应用 |
| CA3179700A1 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| AU2021268345A1 (en) | 2020-05-05 | 2022-11-10 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| CN115707685A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种制备胺-环氧卤丙烷聚合单体的方法及产物和*** |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416884A (en) | 1978-04-12 | 1983-11-22 | Otsuka Pharmaceutical Co., Ltd. | Piperazinylbenzoheterocyclic compounds |
| AU3042601A (en) | 2000-01-24 | 2001-07-31 | Thrombogenix Pty Ltd | Therapeutic morpholino-substituted compounds |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| WO2004016607A1 (en) | 2002-08-16 | 2004-02-26 | Kinacia Pty Ltd. | Inhibition of phosphoinositide 3-kinase beta |
| PL1660484T3 (pl) | 2003-05-09 | 2009-02-27 | Hoffmann La Roche | Metyloindole i metylopirolopirydyny jako agoniści receptora adrenergicznego α-1 |
| US20070083053A1 (en) * | 2003-06-27 | 2007-04-12 | Nissan Chemical Industries, Ltd. | Process for producing indole compound |
| WO2006019831A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| ITMI20060621A1 (it) | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
| AR054438A1 (es) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
| EP1895997A2 (en) | 2005-05-26 | 2008-03-12 | Kudos Pharmaceuticals Ltd | Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies |
| CN101309904A (zh) | 2005-09-29 | 2008-11-19 | 惠氏公司 | 作为单胺再摄取调节剂用于治疗血管舒缩症状(vasomotorsymptoms，vms)的1－(1h－吲哚－1－基)－3－(甲基氨基)－1－苯基丙－2－醇衍生物和相关化合物 |
| TWI418556B (zh) | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| WO2008148074A2 (en) | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
| BRPI0814503A2 (pt) | 2007-07-09 | 2017-05-16 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito anti-proliferativo em um animal de sangue quente, e para tratar uma doença, e, composição farmacêutica |
| WO2009007749A2 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| EA018708B1 (ru) | 2007-07-09 | 2013-10-30 | Астразенека Аб | ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K |
| WO2009007748A2 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| ES2425183T3 (es) | 2007-08-14 | 2013-10-11 | Concert Pharmaceuticals Inc. | Derivados de oxazolidinonas sustituidas |
| EP2062889A1 (de) | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
| CN102924412A (zh) | 2008-01-25 | 2013-02-13 | 先正达参股股份有限公司 | 用作杀虫剂的2-氰基苯基磺酰胺衍生物 |
| JP2012508692A (ja) * | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | 脂肪酸結合タンパク質（ｆａｂｐ）の阻害薬 |
| TWI469965B (zh) | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| DK2448927T3 (da) | 2009-07-02 | 2014-06-16 | Sanofi Sa | Hidtil ukendte (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amidderivater, fremstilling deraf og farmaceutisk anvendelse deraf som akt-phosphoryleringshæmmere |
-
2011
- 2011-12-22 PL PL11805849T patent/PL2658844T3/pl unknown
- 2011-12-22 PT PT118058494T patent/PT2658844T/pt unknown
- 2011-12-22 LT LTEP11805849.4T patent/LT2658844T/lt unknown
- 2011-12-22 DK DK11805849.4T patent/DK2658844T3/en active
- 2011-12-22 HU HUE11805849A patent/HUE030393T2/en unknown
- 2011-12-22 US US13/977,396 patent/US9133168B2/en active Active
- 2011-12-22 SI SI201131075A patent/SI2658844T1/sl unknown
- 2011-12-22 EP EP11805849.4A patent/EP2658844B1/fr active Active
- 2011-12-22 WO PCT/EP2011/073875 patent/WO2012089633A1/fr active Application Filing
- 2011-12-22 ES ES11805849.4T patent/ES2612492T3/es active Active
-
2017
- 2017-01-25 HR HRP20170119TT patent/HRP20170119T1/hr unknown
- 2017-01-26 CY CY20171100117T patent/CY1118858T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2658844A1 (fr) | 2013-11-06 |
| HUE030393T2 (en) | 2017-05-29 |
| SI2658844T1 (sl) | 2017-02-28 |
| HRP20170119T1 (hr) | 2017-03-24 |
| DK2658844T3 (en) | 2017-02-06 |
| WO2012089633A9 (fr) | 2012-08-23 |
| PL2658844T3 (pl) | 2017-04-28 |
| WO2012089633A1 (fr) | 2012-07-05 |
| US9133168B2 (en) | 2015-09-15 |
| PT2658844T (pt) | 2017-01-24 |
| EP2658844B1 (fr) | 2016-10-26 |
| US20130274253A1 (en) | 2013-10-17 |
| ES2612492T3 (es) | 2017-05-17 |
| CY1118858T1 (el) | 2018-01-10 |
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