KR970032863A - 활성산소-유리기 소거제 - Google Patents

활성산소-유리기 소거제 Download PDF

Info

Publication number
KR970032863A
KR970032863A KR1019960069207A KR19960069207A KR970032863A KR 970032863 A KR970032863 A KR 970032863A KR 1019960069207 A KR1019960069207 A KR 1019960069207A KR 19960069207 A KR19960069207 A KR 19960069207A KR 970032863 A KR970032863 A KR 970032863A
Authority
KR
South Korea
Prior art keywords
free radical
group
diseases
active oxygen
represent
Prior art date
Application number
KR1019960069207A
Other languages
English (en)
Other versions
KR100468109B1 (ko
Inventor
히토시 엔도오
카주하루 이에나가
Original Assignee
코니시 진우에몬
닛폰조키세야쿠 카부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 코니시 진우에몬, 닛폰조키세야쿠 카부시키가이샤 filed Critical 코니시 진우에몬
Publication of KR970032863A publication Critical patent/KR970032863A/ko
Application granted granted Critical
Publication of KR100468109B1 publication Critical patent/KR100468109B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 제제화(製劑化)가 용이하고 부작용이 적으며, 또, 경구투여가 가능한 새로운 활성산소-유리기 소거제를 제공하는 것을 목적으로 한다.
본 발명의 활성산소-유리기 소거제는, 다음의 일반식 (Ⅰ)로 표시되는 히단토인 유도체를 유효성분으로서 함유한다.
(식에서 R1및 R2는 각각 동일 혹은 다른 수소, 알킬기 또는 시클로알킬기를 표시하며, X, Y는 각각 동일 혹은 다른 수소, 알킬기, 수산기 또는 , 알콕시기, 혹은, X 및 Y에서 옥소기를 표시한다.)
상시한 히단토인 유도체는, 활성산소-유리기 소거작용이 있으므로, 활성산소나 유리기가 관여하는 질환, 예컨대, 심근경색, 재관류장해, 뇌경색, 자기면역질환, 선유증, 폐질환, 피부질환, 관절염, 항암제의 부작용, 방사선장해, 세균성 쇼크, 염증성 질환, 백내장 등 다양한 질화을 치료하기 위한 약제로서 유용하다.

Description

활성산소-유리기 소거제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(Ⅰ)로 표시되는 히단토인 유도체 또는 그 약학적으로 허용되는 염을 유호성분으로서 함유하는 활성산소-유리기 소거제.
    (식에서 R1및 R2는 각각 동일 혹은 다른 수소, 알킬기 또는 시클로알킬기를 표시하며, X, Y는 각각 동일 혹은 다른 수소, 알킬기, 수산기 또는 알콕시기, 혹은 X 및 Y에서 옥소기를 표시한다.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960069207A 1995-12-20 1996-12-20 히단토인유도체또는그약학적으로허용되는염을유효성분으로함유하는의약조성물 KR100468109B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34983195 1995-12-20
JP95-349831 1995-12-20

Publications (2)

Publication Number Publication Date
KR970032863A true KR970032863A (ko) 1997-07-22
KR100468109B1 KR100468109B1 (ko) 2005-04-13

Family

ID=18406411

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960069207A KR100468109B1 (ko) 1995-12-20 1996-12-20 히단토인유도체또는그약학적으로허용되는염을유효성분으로함유하는의약조성물

Country Status (11)

Country Link
US (1) US6197806B1 (ko)
EP (1) EP0780125B1 (ko)
KR (1) KR100468109B1 (ko)
CN (1) CN1093401C (ko)
AT (1) ATE200622T1 (ko)
AU (1) AU705447B2 (ko)
CA (1) CA2193551C (ko)
DE (1) DE69612540T2 (ko)
DK (1) DK0780125T3 (ko)
ES (1) ES2158223T3 (ko)
TW (1) TW461814B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100648062B1 (ko) * 1998-11-16 2006-11-23 니폰 조키 세야쿠 가부시키가이샤 난치성 혈관염 치료제

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1112072A2 (en) * 1998-08-31 2001-07-04 Sentron Medical, Inc. Methimazole derivatives and tautomeric cyclic thiones to treat autoimmune diseases
JP4711523B2 (ja) * 2001-02-13 2011-06-29 日本臓器製薬株式会社 低アルブミン血症改善剤
JPWO2002083649A1 (ja) * 2001-04-11 2004-08-05 千寿製薬株式会社 新規イミダゾリジンジオン誘導体およびその医薬用途
RU2302861C3 (ru) * 2001-11-19 2017-04-14 Медигене Аг Лекарственное средство для лечения вирусных кожных и опухолевых заболеваний
TWI353979B (en) * 2002-04-10 2011-12-11 Nippon Zoki Pharmaceutical Co Novel crystal form of 5-hydroxy-1-methylhydantoin
US20060241162A1 (en) * 2005-04-20 2006-10-26 Kaoru Okamoto Optically active (R)-hydantoin derivative
US20060241163A1 (en) * 2005-04-20 2006-10-26 Kaoru Okamoto Optically active (S)-hydantoin derivative
CN101732348B (zh) 2008-11-11 2015-01-14 威世药业（如皋）有限公司 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途
BRPI1107312B1 (pt) * 2011-11-25 2021-09-08 Universidade Federal De Santa Catarina Composto de acil-hidrazona
EP2801573A1 (en) * 2013-05-09 2014-11-12 Sanofi Hydantoine derivatives as CD38 inhibitors
CN103360320B (zh) * 2013-07-30 2015-12-02 邱智东 1-甲基海因的制备方法
CN110740729B (zh) * 2017-06-13 2023-05-16 国立研究开发法人国立癌症研究中心 致癌抑制剂

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099007A (en) 1969-04-02 1978-07-04 Hoechst Aktiengesellschaft N,n-substituted 2,4,5-triketoimidazolidines and a process for their preparation
US3818031A (en) 1971-03-26 1974-06-18 Ciba Geigy Corp Imidazolidinetrionecarboxylic acid derivatives
IL39042A (en) 1971-03-26 1976-04-30 Ciba Geigy Ag 2,4,5-trioxoimidazolidine-1-carboxylic acid derivatives,their preparation and their use for the control of plant metabolism
CH563711A5 (en) 1972-03-03 1975-07-15 Ciba Geigy Ag Agents for regulating plant metabolism - contg. imidazolidine-2,4,5-trione-3-carboxylic acid derivs.
DE2612926A1 (de) 1976-03-26 1977-10-06 Boehringer Mannheim Gmbh Neue acyl-derivate der 6-(alpha- amino-phenylacetamido)-penicillansaeure
JPH0686436B2 (ja) 1984-11-15 1994-11-02 日本臓器製薬株式会社 新規ヒダントイン誘導体及び該化合物を含有する医薬組成物
AU578068B2 (en) 1984-03-08 1988-10-13 Nippon Zoki Pharmaceutical Co., Ltd. Hydantoin derivatives and pharmaceutical compositions containing them
US4658830A (en) 1984-08-08 1987-04-21 Survival Technology, Inc. Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms
US4661469A (en) 1984-08-08 1987-04-28 Survival Technology, Inc. t-PA composition capable of being absorbed into the blood stream and method of administration
US4656034A (en) 1985-05-20 1987-04-07 Survival Technology, Inc. Absorption enhancing agents
US4832682A (en) 1984-08-08 1989-05-23 Survival Technology, Inc. Injection method and apparatus with electrical blood absorbing stimulation
AU4674385A (en) 1984-08-08 1986-03-07 Survival Technology Inc. Absorption enhancing agents
US5078680A (en) 1984-08-08 1992-01-07 Survival Technology, Inc. Automatic injector for emergency treatment
US5340829A (en) * 1984-11-20 1994-08-23 Washington Research Foundation Immunoregulatory agents
EP0194226B1 (en) 1985-02-06 1990-02-07 Nippon Zoki Pharmaceutical Co. Ltd. A pharmaceutical composition containing an imidazolidinetrione derivative or pharmaceutically acceptable salt thereof
JPH0764729B2 (ja) 1985-02-06 1995-07-12 日本臓器製薬株式会社 イミダゾリジントリオン誘導体を含有する医薬組成物
JP2567593B2 (ja) 1986-12-29 1996-12-25 日本臓器製薬株式会社 イミダゾリジントリオン誘導体及び該化合物を有効成分として含有するアレルギ−性疾患治療剤
JPS6456614A (en) 1987-08-27 1989-03-03 Ono Pharmaceutical Co Maillard reaction inhibitor
JPH01156965A (ja) 1987-09-29 1989-06-20 Taiho Yakuhin Kogyo Kk チオヒダントイン化合物
JP2544183B2 (ja) 1988-07-29 1996-10-16 日本臓器製薬株式会社 新規パラバン酸誘導体及び該化合物を有効成分として含有する医薬組成物
JP2817219B2 (ja) 1988-09-08 1998-10-30 武田薬品工業株式会社 カルバジン酸誘導体、その製造法及び製剤
JPH02225485A (ja) 1989-02-27 1990-09-07 Taiho Yakuhin Kogyo Kk チエノピリミジン―３―酢酸誘導体
CA2011899A1 (en) 1989-03-13 1990-09-13 Masaaki Toda Benzopyran derivatives
JP2678499B2 (ja) 1989-08-09 1997-11-17 日本臓器製薬 株式会社 ***毒素低下剤
JPH0667827A (ja) 1992-08-18 1994-03-11 Nec Software Ltd データ表示制御装置
JP3267698B2 (ja) 1992-10-27 2002-03-18 株式会社三和化学研究所 ヒダントイン誘導体及びその塩並びにこれらを有効成分とするメイラード反応阻害剤
US5677322A (en) 1993-02-26 1997-10-14 Otsuka Pharmaceutical Co., Ltd. Maillard reaction inhibitor
JPH06305964A (ja) 1993-02-26 1994-11-01 Otsuka Pharmaceut Co Ltd メイラード反応阻害剤
ES2155134T3 (es) 1994-07-29 2001-05-01 Suntory Ltd Derivados de imidazolidina y su utilizacion.
JPH08157473A (ja) 1994-10-06 1996-06-18 Nissan Chem Ind Ltd ピラゾール系チアゾリジン類
US5681843A (en) 1994-12-20 1997-10-28 Nippon Zoki Pharmaceutical Co., Ltd. Parabanic acid derivatives
US5912261A (en) 1994-12-20 1999-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Carboxyalkyl heterocyclic derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100648062B1 (ko) * 1998-11-16 2006-11-23 니폰 조키 세야쿠 가부시키가이샤 난치성 혈관염 치료제

Also Published As

Publication number Publication date
CA2193551C (en) 2006-03-21
AU705447B2 (en) 1999-05-20
DE69612540T2 (de) 2001-08-30
TW461814B (en) 2001-11-01
CN1093401C (zh) 2002-10-30
DE69612540D1 (de) 2001-05-23
CA2193551A1 (en) 1997-06-21
EP0780125A3 (en) 1997-11-05
ATE200622T1 (de) 2001-05-15
ES2158223T3 (es) 2001-09-01
DK0780125T3 (da) 2001-05-07
US6197806B1 (en) 2001-03-06
AU7641496A (en) 1997-06-26
EP0780125B1 (en) 2001-04-18
CN1159324A (zh) 1997-09-17
KR100468109B1 (ko) 2005-04-13
EP0780125A2 (en) 1997-06-25

Similar Documents

Publication Publication Date Title
KR970032863A (ko) 활성산소-유리기 소거제
TNSN04246A1 (fr) Derives d'heteroarylamides benzocondenses de thienopyridines utiles comme agents therapeutiques, compositions pharmaceutiques les contenant et methodes pour leur utilisation
KR950016738A (ko) 알쯔하이머 질병의 억제 방법
FR2708605A1 (fr) Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
KR950016744A (ko) 트롬빈을 저해하는 방법
HUP0301625A2 (hu) Réztartalmú amin-oxidáz inhibitor hatású 1,3,4-oxadiazin-vegyületek, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására
DE69232854D1 (de) Bizyklische fibrinogenantagonisten
FR2708606A1 (fr) Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
ES2150489T3 (es) 1-amidinofenil-pirrolidonas, -piperidinonas, -azetinonas como inhibidores de la agregacion de plaquetas.
DE69426331D1 (de) Arzneimittel gegen nervöse erkrankungen
ES2161291T3 (es) N-(indol-2-carbonil)amidas y derivados como inhibidores de la glucogeno fosforilasa.
MY130668A (en) Isothiazole derivatives useful as anticancer agents
FR2714378B1 (fr) Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
ES2120728T3 (es) Inhibidores de la agregacion de plaquetas.
RU94044436A (ru) Способы подавления атрофии кожи и влагалища
CA2263203A1 (en) 3,6-ketal and enol ether macrolide antibiotics
TNSN97044A1 (fr) Derives de quinoxalinedone, procedes et intermediaires pour leur preparation, et compositions pharmaceutiques les contenant.
WO2003048164A3 (en) Adenosine a2a receptor antagonists
FR2361901A1 (fr) Derives de substitution de nucleotides et medicament contenant ces substances
KR950016723A (ko) 자가면역 질병의 억제 방법
TNSN00235A1 (fr) Derives d'heterocyclo-alkylsulfonylpyrazole nouveaux, procede pour leur preparation et compositions les contenant
KR950016731A (ko) 지루 및 좌창의 억제 방법
TNSN00250A1 (fr) Composes nouveaux inhibiteurs de pcp, procede pour leur preparation et compositions les contenant
KR950016727A (ko) 트롬보모듈린 발현을 증가시키는 방법
KR910004191A (ko) 신질환치료제

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20140103

Year of fee payment: 10

FPAY Annual fee payment

Payment date: 20141120

Year of fee payment: 11

FPAY Annual fee payment

Payment date: 20160108

Year of fee payment: 12

EXPY Expiration of term