KR960004341A - 치환1-(7-클로로 퀴놀린-4-일) 피라졸-3- 카르복스아미드 n-옥시드 유도체, 그의 제조 방법 및 그를 함유하는 약학적 조성물 - Google Patents
치환1-(7-클로로 퀴놀린-4-일) 피라졸-3- 카르복스아미드 n-옥시드 유도체, 그의 제조 방법 및 그를 함유하는 약학적 조성물 Download PDFInfo
- Publication number
- KR960004341A KR960004341A KR1019950020074A KR19950020074A KR960004341A KR 960004341 A KR960004341 A KR 960004341A KR 1019950020074 A KR1019950020074 A KR 1019950020074A KR 19950020074 A KR19950020074 A KR 19950020074A KR 960004341 A KR960004341 A KR 960004341A
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- South Korea
- Prior art keywords
- formula
- compound
- hydrogen
- cycloalkylmethyl
- methoxyethyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
본 발명은 뉴로텐신 길항제로서 사용될 수 있는 하기 일반식(Ⅰ)의 화합물 및 그의 염에 관한 것이다.
[식중, -T는 수소, C1-C4-알킬, C3-C8-시클로알킬, C3-C8-시클로알킬메틸 또는 메톡시에틸이고 : - - NH-AA(OH)기는 하기 식의 아미노산 잔기이다.
(상기 식중, X는 수소, C1-C5-알킬 또는 C3-C15비-방향족 카르보시클릭 라디칼이고 X´는 수소이거나; 또는 양자택일적으로 X와 X´가 그것들이 결합되어 있는 탄소원자와 함께 C3-C15비-방향족 카르보사이클을 형성한다)].
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 식(Ⅰ)의 화합물 및 그의 염 :[식중, -T는 수소, C1-C4-알킬, C3-C8-시클로알킬, C3-C8-시클로알킬메틸 또는 메톡시에틸이고 : - - NH-AA(OH)기는 하기 식의 아미노산 잔기이다.(상기 식중, X는 수소, C1-C5-알킬 또는 C3-C15비-방향족 카르보시클릭 라디칼이고 X´는 수소이거나; 또는 양자택일적으로 X와 X´가 그것들이 결합되어 있는 탄소원자와 함께 C3-C15비-방향족 카르보사이클을 형성한다)].
- 제1항에 있어서, T는 메틸 또는 시클로프로필메틸기이고, -NH-AA(OH)기는 2-아미노아다만탄-2-카르복실산 잔기의 화합물 및 그의 염.
- 하기 식(Ⅱ)의 유도체를 실온하에 비양자성 용매 내에서 산화제로 처리하여 식(Ⅰ)의 화합물 및 그의 염의 제조방법.(식중, T 및 -NH-AA(OH)는 제1항에서 식(Ⅰ)의 화합물에 대하여 정의한 것과 같다).
- 하기 식(Ⅳ)의 산 :(식중, T는 C3-C8-시클로알킬, C3-C8-시클로알킬메틸 또는 메톡시에틸이다).
- 하기 식(Ⅱ)의 아미드 :(식중, T는 C3-C8-시클로알킬, C3-C8-시클로알킬메틸 또는 메톡시에틸이며, -NH-AA(OH)는 제1항에서 정의한 것과 같다).
- 제1항 및 2항중 한 항에 따른 화합물, 또는 약학적으로 허용가능한 그의 염이, 필요하다면, 유효성분으로서 존재하는 약학적 조성물.
- 제6항에 있어서, 투약 단위체 형태인 약학적 조성물.
- 제7항에 있어서, 하나 이상의 약학적으로 허용가능한 부형체와 혼합된 0.5 내지 250㎎의 유효성분으로서 존재하는 약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR94-08459 | 1994-07-08 | ||
FR9408459A FR2722193B1 (fr) | 1994-07-08 | 1994-07-08 | Derives n-oxydes de 1-(7-chloro-4-quinoleinyl)pyrazole-3-carboxamides substitues, procede pour leur preparation et les compositions pharmaceitiques les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960004341A true KR960004341A (ko) | 1996-02-23 |
Family
ID=9465167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950020074A KR960004341A (ko) | 1994-07-08 | 1995-07-08 | 치환1-(7-클로로 퀴놀린-4-일) 피라졸-3- 카르복스아미드 n-옥시드 유도체, 그의 제조 방법 및 그를 함유하는 약학적 조성물 |
Country Status (17)
Country | Link |
---|---|
US (1) | US5561234A (ko) |
EP (1) | EP0695747A1 (ko) |
JP (1) | JPH0841051A (ko) |
KR (1) | KR960004341A (ko) |
CN (1) | CN1042533C (ko) |
AU (1) | AU695588B2 (ko) |
CA (1) | CA2153432A1 (ko) |
FI (1) | FI953360A (ko) |
FR (1) | FR2722193B1 (ko) |
HU (1) | HUT73175A (ko) |
IL (1) | IL114500A (ko) |
NO (1) | NO952715L (ko) |
NZ (1) | NZ272525A (ko) |
PL (1) | PL309546A1 (ko) |
RU (1) | RU2145323C1 (ko) |
TW (1) | TW318847B (ko) |
ZA (1) | ZA955673B (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0968001B1 (en) * | 1997-02-03 | 2003-11-05 | Mallinckrodt Inc. | Method for the detection and localization of malignant human pancreatic tumours |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5283852A (en) * | 1976-01-01 | 1977-07-13 | Christiaens Sa A | Pyridine derivatives |
US4746671A (en) * | 1985-11-04 | 1988-05-24 | Janssen Pharmaceutica N.V. | Pharmaceutical use of [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters |
JPH02268162A (ja) * | 1989-04-10 | 1990-11-01 | Fujisawa Pharmaceut Co Ltd | ジフェニルピリジン誘導体 |
FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
-
1994
- 1994-07-08 FR FR9408459A patent/FR2722193B1/fr not_active Expired - Fee Related
-
1995
- 1995-07-06 JP JP7170712A patent/JPH0841051A/ja active Pending
- 1995-07-06 TW TW084106976A patent/TW318847B/zh active
- 1995-07-06 EP EP95401626A patent/EP0695747A1/fr not_active Withdrawn
- 1995-07-07 FI FI953360A patent/FI953360A/fi unknown
- 1995-07-07 IL IL11450095A patent/IL114500A/xx active IP Right Grant
- 1995-07-07 CA CA002153432A patent/CA2153432A1/en not_active Abandoned
- 1995-07-07 US US08/499,726 patent/US5561234A/en not_active Expired - Fee Related
- 1995-07-07 HU HU9502081A patent/HUT73175A/hu unknown
- 1995-07-07 NZ NZ272525A patent/NZ272525A/en unknown
- 1995-07-07 PL PL95309546A patent/PL309546A1/xx unknown
- 1995-07-07 RU RU95113184A patent/RU2145323C1/ru active
- 1995-07-07 CN CN95109950A patent/CN1042533C/zh not_active Expired - Fee Related
- 1995-07-07 ZA ZA955673A patent/ZA955673B/xx unknown
- 1995-07-07 NO NO952715A patent/NO952715L/no unknown
- 1995-07-07 AU AU24867/95A patent/AU695588B2/en not_active Ceased
- 1995-07-08 KR KR1019950020074A patent/KR960004341A/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JPH0841051A (ja) | 1996-02-13 |
US5561234A (en) | 1996-10-01 |
AU695588B2 (en) | 1998-08-20 |
CN1042533C (zh) | 1999-03-17 |
EP0695747A1 (fr) | 1996-02-07 |
ZA955673B (en) | 1996-02-20 |
FR2722193A1 (fr) | 1996-01-12 |
IL114500A0 (en) | 1995-11-27 |
FI953360A (fi) | 1996-01-09 |
TW318847B (ko) | 1997-11-01 |
IL114500A (en) | 1999-11-30 |
HU9502081D0 (en) | 1995-09-28 |
NO952715D0 (no) | 1995-07-07 |
HUT73175A (en) | 1996-06-28 |
RU2145323C1 (ru) | 2000-02-10 |
CN1120042A (zh) | 1996-04-10 |
CA2153432A1 (en) | 1996-01-09 |
AU2486795A (en) | 1996-01-18 |
NZ272525A (en) | 1997-02-24 |
FI953360A0 (fi) | 1995-07-07 |
FR2722193B1 (fr) | 1996-10-04 |
PL309546A1 (en) | 1996-01-22 |
NO952715L (no) | 1996-01-09 |
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